In no order of presumed value or significance the two grand revolutionary scientific achievements  that begin changing us are:

1.  the concilience of the sciences of life and technology of artificial intelligence, advanced computing and software (including life programming a la Venter and possibly consciousness programming) towards the "cylon" creation;

2.  the knowledge of how space and time emerge: the tectonics and characterization of our very Universe (with the Large Hadron Collider, relevant accelerator and non-accelerator fundamental research projects  including a large number of astro-particle-gravity-cosmology observatories terrestrial and in space)

Both are products of the curious ever growing capacity of the human intelligence and craftsmanship. Both manifest  through science and technology no signs of saturation or taming.  Both are changing our cognitive reference systems and the compass of knowledge.