THREE TULIPS
a new exhibition by Katinka Matson



2009

WHAT WILL CHANGE EVERYTHING?


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151 CONTRIBUTORS
(107,000 words)

Alan Alda
Chris Anderson

Alun Anderson
Stephon H. Alexander
Mahzarin R. Banaji
John D. Barrow
Patrick Bateson
Gregory Benford
Yochai Benkler
Jesse Bering
David Berreby
Jamshed Bharucha
Susan Blackmore
David Bodanis
Stefano Boeri
Lera Boroditsky
Nick Bostrom
Stewart Brand
Rodney Brooks
David Buss
William Calvin
Leo Chalupa
Nicholas A. Christakis
Andy Clark
Gregory Cochran

M. Csikszentmihalyi
Austin Dacey
David Dalrymple
Paul Davies
Richard Dawkins
Aubrey de Grey

Emanuel Derman
Daniel C. Dennett
Keith Devlin
Betsy Devine
Eric Drexler
Freeman Dyson

George Dyson

David Eagleman
Brian Eno
Juan Enriquez
Daniel Everett
Paul Ewald
Christine Finn
Eric Fischl
Helen Fisher
Kenneth W. Ford

Richard Foreman
Howard Gardner
Joel Garreau
James Geary
David Gelernter
Neil Gershenfeld
Marcelo Gleiser
Daniel Goleman
Dominique Gonzalez-Foerster
Brian Goodwin
Alison Gopnik
April Gornik
John Gottman
Jonathan Haidt
Haim Harari
Henry Harpending
Sam Harris
Marc D. Hauser
Marti Hearst
Roger Highfield
W. Daniel Hillis
Gerald Holton
Donald D. Hoffman

Verena Huber-Dyson
Nicholas Humphrey
Marco Iacoboni
Eric Kandel
Stuart Kauffman
Kevin Kelly
Marcel Kinsbourne, MD
Brian Knutson
Terence Koh
Bart Kosko
Stephen M. Kosslyn
Kai Krause
Laurence Krauss
Andrian Kreye
A. Garrett Lisi
Seth Lloyd
Gary Marcus
Ian McEwan
Thomas Metzinger
Oliver Morton
David G. Myers
P.Z. Myers
Steve Nadis
Monica Narula
Randolph Nesse
Tor Nørretranders
Hans Ulrich Obrist
James J. O'Donnell

Gloria Origgi
Dean Ornish, M.D.
Mark Pagel
Bruce Parker
Philippe Parreno
Gregory Paul
Irene Pepperberg
Clifford A. Pickover
Steven Pinker
Ernst Pöppel
Corey S. Powell
Robert R. Provine
Lisa Randall
Ed Regis
Howard Rheingold
Carlo Rovelli

Douglas Rushkoff
Karl Sabbagh
Paul Saffo
Scott Sampson
Robert Sapolsky
Dimitar Sasselov
Roger Schank
Stephen H. Schneider
Peter Schwartz
Charles Seife
Gino Segrè
Tino Sehgal
Terrence Sejnowski
Martin Seligman
Robert Shapiro
Rupert Sheldrake
Michael Shermer
Kevin Slavin
Barry Smith
Laurence C. Smith
Lee Smolin
Dan Sperber
Maria Spiropulu
Paul J. Steinhardt
Nassim Nicholas Taleb
Timothy Taylor
Max Tegmark
Frank J. Tipler
John Tooby & Leda Cosmides
Joseph F. Traub
Sherry Turkle
Alexander Vilenkin
J. Craig Venter
Frank Wilczek
Ian Wilmut
Lewis Wolpert
Anton Zeilinger



EL MUNDO
January 3, 2009

Impíos deseos al empezar el año
By Arcadia Espada

Al rito solar del Año Nuevo, el concierto de Viena (me paso las dos horas de valses, fantaseando con el frío de fuera, y la choucroute caliente y morosa que le espera al primer concertino: todo lo que me gusta me da hambre) y los saltos en Garmisch Partenkirchen se ha unido ya la pregunta de Edge. Al despuntar el alba, y con todas las ilusiones intactas, Brockman&Guests sacuden la resaca, preguntan y se responden. Lo hacen desde 1998 y este año proponen: BEl subtítulo lleva una consoladora precisión: se trata de cambios y desarrollos científicos que podamos ver en vida. El resumen de las ideas de Edge, la navajita más afilada de la cultura contemporánea, siempre es complicado. Excepto, claro está, en el caso de los dos o tres artistas que figuran cada año a modo de sansivieras: todas sus respuestas se pueden ignorar. Deberás fiarte, pues, de mi gusto y de mis obsesiones. También de las limitaciones del formato de la carta. Y, principalmente, de mis límites: no entiendo todas las respuestas. En todo caso, aquí tienes el catálogo completo....

SPANISH TEXT
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SPEIGEL ONLINE
January 10, 2009

HEUTE IN DEN FEUILLETONS

Das Versagen der Linken im Gaza-Krieg

In der "SZ" erinnert sich Sibylle Lewitscharoff an ihre Zeit bei der Gruppe Spartacus Bolschewiki-Leninisten. Die "NZZ" hat in Detroit in die vielen Gesichter des Nichts gesehen. Und die "FAZ" erkennt in der chinesischen Markenpiraterie die Intelligenz des Volkes.

Frankfurter Allgemeine Zeitung, 10.01.2009...Weiteres: Wie es aussieht, "wenn die Intelligenz von sich selber träumt", weiß Thomas Thiel seit der Umfrage des Magazins edge.org unter hochdekorierten Naturwissenschaftlern zu der Frage: "Welche Entwicklung könnte könnte zu Ihren Lebzeiten alles ändern?"


FRANKFURTER ALLGEMEINE ZEITUNG
January 10, 2009

Visionen der Wissenschaft
Wenn die Intelligenz von sich selber träumt
Von Thomas Thiel



Man steigt, heißt es, nicht zweimal in denselben Fluss. Aber man hofft doch, als derselbe ans Ufer zurückzukehren. Nur im Horizont dieses Bildes zeigt sich die Radikalität der Frage, die der Literaturagent John Brockman von der Organisation "Edge" (Edge - die Website) der wissenschaftlichen Gemeinschaft vorgelegt hat: „Welche Entwicklung könnte zu Ihren Lebzeiten alles ändern?" Wie zu jedem Jahreswechsel fordert Brockman mit seiner Frage auf der Website von Edge die Phantasie der Wissenschaftler heraus, den Mut zum großen Gedanken. Es antworten oft hochdekorierte Forscher wie Ian Wilmut, Craig Venter oder Daniel Dennett, die in (Natur-)Wissenschaftlern und Technikern und nicht mehr im Literaten oder Historikern den zeitgemäßen Typus des Intellektuellen sehen.

Fasst man den Grundtenor der mehr als einhundertfünfzig Antworten zusammen, so gehört die Zukunft den Genetikern, Neurobiologen und Informatikern oder jedenfalls solchen Wesen, die sich die Ergebnisse neurobiologischer, informationstechnologischer und genetischer Forschung zunutze machen. Ob sie noch sinnvollerweise Menschen genannt werden sollten, ist dabei eine berechtigte Frage. ...

GOOGLE TRANSLATION


Letras Libres
December 16, 2008

Science in the Street

By Ramón González & Férriz Y Diego Salazar

Humanism today limps as Andalusia ostensibly despises science. Gonzalez and Salazar Férriz indicate a new and commendable effort to remedy that Soanish ignorance: Culture 3.0.

In the preface to the recent reissue of The betrayal of the intellectuals, 1927 Julien Benda (Galaxia Gutenberg), Fernando Savater stated that "perhaps the greatest paradox of the paradoxes of the twentieth century is this: there has never been a time in human history in which more developed the ability to produce tools and knowledge the inner structure of reality in all fields. So, never was more scientific and technical brilliance. But neither had ever so many ideological movements based (or better, desfondados) as irrational, dogmatic or unverifiable, above all, never was such a wealth of supporters of rapture or intuitive certainty blood among the elite of servers for high spiritual functions. "In the words of Benda," men whose function is to defend and selfless eternal values such as justice and reason, and I call intellectuals have betrayed that role for practical interests, which often result in the conversion of a mere intellectual ideologue who aspires to a space power...

...Following the wake of Snow and probably trying to repair the betrayal of Benda-speaking, John Brockman in 1988 founded the Edge Foundation (www.edge.org), an organization that seeks to reintegrate, under the idea of a "Third Culture "scientific and humanistic discourse and contribute to that science has a key role in the discussion of public affairs. ...

SPANISH ORIGINAL
GOOGLE TRANSLATION


NEWS-OBSERVER
January 4, 2009

Science visions, dark and bright

By J. Peder Zane

Talk about change was more plentiful in 2008 than loose coins in an old couch.
Despite all the lip-flapping, that place where gods and devils dwell -- the details -- was largely unexplored.

The Obama administration will soon offer its ideas for reviving the economy and reshaping America's foreign policy. But politicians aren't the only ones who can remake the world.

Scientists have at least as much power to transform our lives and history. What "game-changing scientific ideas and developments" do they expect to occur during the next few decades?

That's the question John Brockman, editor of the Web site edge.org, posed to about 160 cutting-edge minds in his 11th annual Edge Question. As in years past, they responded with bold, often thrilling, sometimes chilling, answers.


THE GUARDIAN
January 2, 2009
SCIENCE BLOG

Richard Dawkins: How would you feel about a half-human half-chimp hybrid?

Dawkins speculates about how a human-chimp hybrid or the discovery of a living Homo erectus would change the way we see the world. — James Randerson

In a late response to Edge.org's annual New Year challenge to the world's leading thinkers, Prof Richard Dawkins has submitted his entry. Edge.org asked scientists, philosophers, artists and journalists "What will change everything?"

Dawkins – author of The Selfish Gene and The God Delusion – muses on the effect of breaking down the barrier between humans and animals, perhaps by the creation of a chimera in a lab or a "successful hybridisation between a human and a chimpanzee".

Here's what he had to say.


THE TELEGRAPH
January 2, 2009


New Year 2009: Leading thinkers offer predictions of 'next big thing'


By Jon Swaine

Leading thinkers - including Craig Venter and Ian McEwan - have marked New Year 2009 by predicting what will be the next big thing to shape the future.

[PHOTO: IAN MCKEWAN/PHILIP HOLLIS]

[Caption: Ian McEwan: predicts the full flourishing of solar technology as one of the next 'big things']

A 150-strong group of scientists, authors, musicians, philosophers and other respected experts were posed the question "What will change everything?"

Their task was set by Edge, an online intellectual discussion group, which claims its membership comprises "the most interesting minds in the world".

The responses spanned new methods of energy production, the dawn of telepathy, freely available artificial intelligence and the colonisation of the Milky Way."

NPR
NPR
January 2, 2009


THE BIG STORY
Weekend reading


ANALYSIS
The Big Question Of The Year

By Linton Weeks

Every year, John Brockman — who runs the nonprofit Edge Foundation in New York — asks a gaggle of forward-thinking people a provocative question.


THE GUARDIAN
January 2, 2009
SCIENCE BLOG

Brian Eno: The feeling that things are inevitably going to get worse

The artist and composer responds to this year's Edge.org question: What will change everything?

[PHOTO: BRIAN ENO/EAMONN MCCABE]

What would change everything is not even a thought. It's more of a feeling.

Human development thus far has been fueled and guided by the feeling that things could be, and are probably going to be, better. The world was rich compared to its human population; there were new lands to conquer, new thoughts to nurture, and new resources to fuel it all. The great migrations of human history grew from the feeling that there was a better place, and the institutions of civilisation grew out of the feeling that checks on pure individual selfishness would produce a better world for everyone involved in the long term.


THE DALLAS MORNING NEWS
January 2, 2009

OPINION PAGE

THE BIG STORY
Weekend reading


Edge World Question 2009: What will change everything?

Annual science survey asks: "What game-changing scientific ideas and developments do you expect to live to see?" Among the answers:

• West Antarctica and sleeping giants
• Quantum laptops
• Mind-reading ...


GLASCOW HERALD
January 2, 2009

Top thinkers divided on whether future is bright

Chris Watt

The predictions range from miracle cures and world peace to economic ruin and nuclear war. If there is a theme to the World Questions 2009, an online survey of some of the world's top thinkers, it would seem to be inconsistency.

Published yesterday on intellectual website edge.org, the survey asked 150 leading scientists, artists and commentators for their views on the single biggest change likely to affect the world during their lifetimes.

The wide range of answers they gave provides a snapshot of the hopes - and fears - that may come to define our times.


BLOGGINGHEADS TV
January 3, 2009

JOHN HORGAN/
GEORGE JOHNSON

Science Saturday: The More Things Change... (27:45)

• Edge contributors answer "What will change everything?"

GJ: We were talking abut great thiigs on the Internet in science...so you read Edge.org' question of the year?

JH: Yes, the annual question from John Brockman, the science book impressario. He's got this great site edge.org 2hich we've talked about before and every year he asks this question and he's asks this ever-growing stable of people, primarily scientists but a of of quasi-scientist pundits to respond this question. The question this year is "What will change everything".

GJ: Yes, Good New Year's Day reading.


PHARYNGULA
January 2, 2009

PZ MYERS

Brockman asks, we answer

GRIST
January 2, 2009

We're gonna need a bigger boat

Scientists and other experts rattle off options for averting climate catastrophe


Meanwhile, the mysterious Edge Foundation released its annual question for 2009, asking smart folks of all disciplines to name what new idea or technology will "change everything." Responses range all over, but there are a few climate-related responses, including British novelist Ian McEwan's prediction that solar technology will really take off and Stanford climatologist Stephen H. Schneider's guess that rapid melting of Greenland's ice sheets will wake up the world to the need to take concerted action on curbing C02 emissions.


BELIEFNET
January 2, 2009

CRUNCH CON BLOG/
RON DREHER

Edge 2009: What will change everything?

If you're familiar with The Edge's annual survey of scientists, science writers and scientific types, you know how fascinating the answers are. Follow the link above to get started reading them -- and then share in the comboxes your own answer to the question, and how you reached that conclusioN


O'REILLY RADAR
January 1, 2009


What Will Change Everything?

By Brady Forrest
Regular Radar contributor Linda Stone sent this in to be posted today.


...Venter imagines creating life from synthetic materials and expects that our view of life, itself, will be transformed.

Nobel Laureate, Frank Wilczek, believes everything will continue to become smaller, faster, cooler, and cheaper -- with its implications of an Internet on steroids and exciting new designer materials.


ARTS & LETTER DAILY
January 1, 2009

Essays and Opinion

Printing – electricity – radio – antibiotics: after them, nothing was the same. Intellectual impresario John Brockman asks a select group of thinkers, “What will change everything?”... more»


THE GUARDIAN
January 1, 2009


Leading thinkers predict technologies that will turn the world upside-down

James Randerson, science correspondent

[Caption: Ian McEwan muses that we will look back and 'wonder why we ever thought we had a problem when we are bathed in such beneficent radiant energy'. Photograph: Getty]

Flying cars, personal jetpacks, holidays on the moon, the paperless office – the predictions of futurologists are, it seems, doomed to fail. The only thing predictable about the future is its unpredictability.

But that has not stopped edge.org – the online intellectual salon – asking which ideas and inventions will provide humanity's next leap forward. In its traditional New Year challenge to the planet's best thinkers it asks, "What will change everything – What game-changing scientific ideas and developments do you expect to live to see?"


THE TIMES
January 1, 2009

Science minds reveal vision of life, the universe and everything

Mark Henderson, Senior Editor

Most scientists like to dream about what will change the world — even if they understand that their own work is never likely to have quite the impact of a Copernicus or a Darwin.

The fascinating breadth of their visions of the future is revealed today by the discussion website edge.com, which has asked some of the world’s finest minds the question: “What will change everything?”


Xconomy
January 1, 2009

What Will Change Everything?

Linda Stone
 

What game-changing ideas can we expect to see in OUR lifetimes?

As each year winds to a close, John Brockman, literary agent representing some of the finest minds in science and technology and the founder of Edge Foundation, poses a provocative question to an international community of physicists, psychologists, futurists, thought leaders, and dreamers. Brockman is a master convener, both online and in real life. This year’s annual Edge question, What will change everything?, generated responses from Freeman Dyson, Danny Hillis, Martin Seligman, Craig Venter, and Juan Enriquez, to name a few. Here are a few highlights.


NEWSWEEK
December 31, 2008

LAB NOTES

Crystal-Ball Time

By Sharon Begley

Every December the online intellectual salon called Edge, presided over by literary agent John Brockman, asks a select (virtual) assembly of scientists to ponder a question, such as what they are optimistic about (2007), what "dangerous" ideas they have (2006) and what they believe is true but cannot prove (2005). As the bell tolls on 2008 and rings in 2009, Edge is unveiling this year’s: "What game-changing scientific ideas and developments do you expect to live to see?"

As usual, the offerings vary as much in quality as a cheap spumante does from Dom Perignon. Predictably, contributors foresee space colonization and the discovery of intelligent life elsewhere in the universe. More intriguing, there are predictions that a new human species will evolve from Homo sapiens, and that we will discover how to identify the brain pattern that indicates a person is about to commit a violent act (and will also discover how to suppress that pattern).



THE GUARDIAN
January 1, 2009

SCIENCE BLOG

Which technological wonders are set to change everything?


The world's greatest thinkers have revealed the ideas and technologies they think will change the world forever. Now it's our turn ...

James Randerson, science correspondent

Futurology is notoriously hit-and-miss. According to 2001: A Space Odyssey, we should already be using suspended animation to send humans to Jupiter

"Through science we create technology and in using our new tools we recreate ourselves." So says the intro to edge.org's annual New Year challenge to the world's greatest thinkers.This year it is asking "What will change everything – What game-changing scientific ideas and developments do you expect to live to see?" And as ever, the great and the good have responded to the call. ...


2008


WHAT HAVE YOU CHANGED YOUR MIND ABOUT?


Edited by John Brockman with an Introduction by Brian Eno


The splendidly enlightened Edge website (www.edge.org) has rounded off each year of inter-disciplinary debate by asking its heavy-hitting contributors to answer one question. I songly recommend a visit.tr


A great event in the Anglo-Saxon culture

As fascinating and weighty as one would imagine

They are the intellectual elite, the brains the rest of us rely on to make sense of the universe and answer the big questions. But in a refreshing show of new year humility, the world's best thinkers have admitted that from time to time even they are forced to change their minds

Even the world’s best brains have to admit to being wrong sometimes: here, leading scientists respond to a new year challenge

Provocative ideas put forward today by leading figures

The world's finest minds have responded with some of the most insightful, humbling, fascinating confessions and anecdotes, an intellectual treasure trove. ... Best three or four hours of intense, enlightening reading you can do for the new year. Read it now.

As in the past, these world-class thinkers have responded to impossibly open-ended questions with erudition, imagination and clarity.

A jolt of fresh thinking...The answers address a fabulous array of issues. This is the intellectual equivalent of a New Year's dip in the lake — bracing, possibly shriek-inducing, and bound to wake you up


Answers ring like scientific odes to uncertainty, humility and doubt; passionate pleas for critical thought in a world threatened by blind convictions


For an exceptionally high quotient of interesting ideas to words, this is hard to beat. ...What a feast of egg-head opinionating!.

2007


WHAT ARE YOU OPTIMISTIC ABOUT?

Edited by John Brockman with an Introduction by Daniel C. Dennett



Was läuft hier richtig?
Der neue Optimi
smus der Wissenschaften kommt gerade zur rechten Zeit
RALF BÖNT


C'est la double question posée par John Brockman, éditeur de Edge à plus de 160 "penseurs de la troisième culture, ces savants et autres penseurs du monde empirique qui, par leur travail ou leurs écrits prennent la place des intellectuels traditionnels en rendant visibles les sens profonds de nos vies, en redéfinissant autant qui nous sommes que ce que nous sommes".

Ça change des unes constamment catastrophiques de nos médias habituels.


But when the scientific thinkers look beyond their own specializations to the big picture, they continue to find cause for cheer — foreseeing an end to war, for example, or the simultaneous solution of our global warming and energy problems. The most general grounds for optimism offered by these thinkers, though, is that big-picture pessimism so often proves to be unfounded.
Global warming, the war on terror and rampant consumerism getting you down? Well, lighten up: here, 17 of the world's smartest scientists and academics share their reasons to be cheerful

Brockman's respondents were forward-looking, describing cutting-edge research that will help combat global warming and other looming problems.


How Doomed Are We?

Edgie's Chris Anderson of TED and Robert Provine of University of Maryland as the proponents of optimism on program concerning Optimism and the Doomsday Clock


a titillating compilation

Peering into their crystal telescopes, the world's leading scientists see a magnificent future

El foro virtual Edge propone buscar razones, no simplemente deseos, para el optimismo. Edge es un club que reúne, segén ellos mismos, algunas de las mentes más interesantes del mundo. Su propósito es estimular discusiones en las fronteras del conocimiento. La intención es llegar al borde del conocimiento mundial, acercándose a las mentes más complejas y refinadas, juntarlas en un foro y hacerlos que se pregunten las preguntas que ellos mismos se hacen. La fundación actúa, de este modo, como surtidora de problemas y alojamiento de réplicas. Cada ano se constituye como Centro Mundial de Preguntas.

God bless those upbeat scientists

Looking through rose-colored microscopes
Why some scientists are optimistic about the future

One way or another the answers should give you a warm glow — either because you agree, or because they make you angry.


Edge's future-themed article is making some news....
From the lips of contributors to the online magazine Edge to God's ears (one wonders if She or It may be listening): dozens of scientists and other thinkers have looked ahead to the future.


a Web site that aims to bridge the gap between scientists and other thinkers

[E]ven in the face of such threats as global warming and religious fundamentalism, scientists remain positive about the future.

People's fascination for religion and superstition will disappear within a few decades as television and the internet make it easier to get information, and scientists get closer to discovering a final theory of everything, leading thinkers argue today.

What are you optimistic about? Why? Tons of brilliant thinkers respond.

What Are You Optimistic About?

Posted by Hemos on Monday January 01, @08:43AM
from the explain-yourself dept.

Intellectual impresario John Brockman puts his annual Edge question to
leading thinkers.


What are you optimistic about? Intellectual impresario John Brockman puts his annual Edge question to leading thinkers...


[A]ccording to Edge — the heady website for world-class scientists and thinkers, and the brainchild of author and entrepreneurial idea man, John Brockman, there's good news ahead.

2006


WHAT IS YOUR DANGEROUS IDEA?

Edited by John Brockman with an Introduction by Steven Pinker and Afterword by Richard Dawkins



KYUNG HANG (Soeul)
The great world-wide scholars talk about their 'dangerous ideas'.


Most of the contributors appear to have interpreted "dangerous" as meaning something like "subversive," challenging to one or another received orthodoxy.

Meine gefährlichste Idee. Seit nunmehr neun Jahren startet die Stiftung Edge mit einer Umfrage zu einem großen generellen Thema ins neue Jahr.

Crónicas Bárbaras Ciencia racista, atractiva pero muy peligrosa.

(Sydney) Into the minds of the believers. With the aim of gathering ideas from the world's leading thinkers on intellectual, philosophical, artistic and literary issues, US writer John Brockman established The Edge Foundation in 1988.

Royal Society president Martin Rees said the most dangerous idea was public concern that science and technology were running out of control.

Audacious Knowledge. What is a dangerous idea? One not assumed to be false, but possibly true?What do you believe is true even though you cannot prove it?"

Seductive power of a hazardous idea. The responses to Brockman's question do not directly engage with each other, but they do worry away at a core set of themes.

Academics see gene cloning perils, untamed global warming and personality-changing drugs as presenting the gravest dangers for the future of civiliztion

Risky ideas; What do scientists currently regard as the most dangerous thoughts?


Be Afraid. Edge.org canvassed scientists for their "most dangerous idea." David Buss, a psychologist at the University of Texas, chose "The Evolution of Evil."

The most dangerous idea. Brockman's challenge is noteworthy because his buddies include many of the world's greatest scientists: Freeman Dyson, David Gelertner, J. Craig Venter, Jared Diamond, Brian Greene.

Dangerous Ideas About Modern Life. Free will does not exist. We are not always created equal. Science will never be able to address our deepest concerns.

Genome sequencing pioneer Craig Venter suggests greater understanding of how genes influence characteristics such as personality, intelligence and athletic capability could lead to conflict in society.

The wilder shores of creativity. He asked his roster of thinkers [...] to nominate an idea, not necessarily their own, they consider dangerous not because it is false, but because it might be true.

From cloning to predetermination of sex: the answers of investigators and philosophers to a question on the online salon Edge.

Who controls humans? God? The genes? Or nevertheless the computer? The on-line forum Edge asked its yearly question — and the answers raised more questions.

La pregunta de l'any. La web Edge.org penjarà l'1 de gener la pregunta de l'any. La del 2005 va ser resposta per 120 ments de l'anomenada 'tercera cultura', que van reflexionar sobre l'enunciat "Què creus que és veritat tot i no poder-ho demostrar?"

THE HANKYOREH (Seoul)

The 117 respondents include Richard Dawkins, Freeman Dyson, Daniel Dennett, Jared Diamond — and that's just the D's! As you might expect, the submissions are brilliant and very controversial.

Gene discoveries highlight dangers facing society. Mankind's increasing understanding of the way genes influence behaviour and the issue's potential to cause ethical and moral dilemmas is one of the biggest dangers facing society, according to leading scientists.

Why it can be a very smart move to start life with a Jewish momma: There is one dangerous idea that still trumps them all: the notion that, as Steven Pinker describes it, "groups of people may differ genetically in their average talents and temperaments". For "groups of people", read "races."

The Earth can cope with global warming, schools should be banned and we should learn to love bacteria. These are among the dangerous ideas revealed by a poll of leading thinkers.

Science can be a risky game, as Galileo learned to his cost. Now John Brockman asks over a hundred thinkers, "What is your most dangerous idea?"

"Our brains are constantly subjected to the demands of multi-tasking and a seemingly endless cacophony of information from diverse sources. "

Very complex systems — whether organisms, brains, the biosphere, or the universe itself — were not constructed by design; all have evolved. There is a new set of metaphors to describe ourselves, our minds, the universe, and all of the things we know in it.

John Brockman Blogs Edge's Annual Question on Huff Po

2005


What Do You Believe Is True Even Though You Cannot Prove It?


What We Believe but Cannot Prove: Today's Leading Thinkers on Science in the Age of Certainty
Edited by John Brockman
Introduction by Ian McEwan


The natural gift of consciousness should be treasured all the more for its transience.

The answers...exert an un- questionable morbid fascination — those are the very ideas that scientists cannot confess in their technical papers.

"Fate largo alle «beautiful minds» di Roberto Casati;;
"La terza cultura di John Brockman" di Armando Massarenti

God (or Not), Physics and, of Course, Love: Scientists Take a Leap: Fourteen scientists ponder everything from string theory to true love.

Space Without Time, Time Without Rest: John Brockman's Question for the Republic of Wisdom — It can be more thrilling to start the New Year with a good question than with a good intention. That's what John Brockman is doing for the eight time in a row.
What do you believe to be true, even though you can't prove it? John Brockman asked over a hundred scientists and intellectuals... more» ... Edge

That's what online magazine The Edge — the World Question Center asked over 120 scientists, futurists, and other interesting minds. Their answers are sometimes short and to the point

Science's Scourge of Believers Declares His Faith in Darwin...
Singolare inchiesta in usa di un sito internet. Ha chiesto ai signori della ricerca di svelare i loro "atti di fede". Sono arrivate le risposte piu' imprevedibili i fantasmi dello scienziato: non ho prove ma ci credo.
To celebrate the new year, online magazine Edge asked some leading thinkers a simple question: What do you believe but cannot prove? Here is a selection of their responses...
Scientists dream too — imagine that
"Fantastically stimulating ...Once you start, you can't stop thinking about that question. It's like the crack cocaine of the thinking world." — BBC Radio 4
Scientists, increasingly, have become our public intellectuals, to whom we look for explanations and solutions. These may be partial and imperfect, but they are more satisfactory than the alternatives.

Bangladesh — The cynic and the optimist, the agnostic and the believer, the rationalist and the obscurantist, the scientist and the speculative philosopher, the realist and the idealist-all converge on a critical point in their thought process where reasoning loses its power.

Il Sole 24 Ore-Domenica Segnalate le vostre cuioosita, chiederemo riposta alle persone piu autorevoli


2004


"What's Your Law?"


"So now, into the breach comes John Brockman, the literary agent and gadfly, whose online scientific salon, Edge.org, has become one of the most interesting stopping places on the Web. He begins every year by posing a question to his distinguished roster of authors and invited guests. Last year he asked what sort of counsel each would offer George W. Bush as the nation's top science adviser. This time the question is "What's your law?"
"John Brockman, a New York literary agent, writer and impresario of the online salon Edge, figures it is time for more scientists to get in on the whole naming thing...As a New Year's exercise, he asked scores of leading thinkers in the natural and social sciences for "some bit of wisdom, some rule of nature, some law-like pattern, either grand or small, that you've noticed in the universe that might as well be named after you."
"John Brockman has posted an intriguing question on his Edge website. Brockman advises his would-be legislators to stick to the scientific disciplines."
"Everything answers to the rule of law. Nature. Science. Society. All of it obeys a set of codes...It's the thinker's challenge to put words to these unwritten rules. Do so, and he or she may go down in history. Like a Newton or, more recently, a Gordon Moore, who in 1905 coined the most cited theory of the technological age, an observation on how computers grow exponentially cheaper and more powerful... Recently, John Brockman went looking for more laws."

2003


"What are the pressing scientific issues for the nation and the world, and what is your advice on how I can begin to deal with them?"


"In 2002, he [Brockman] asked respondents to imagine that they had been nominated as White House science adviser and that President Bush had sought their answer to 'What are the pressing scientific issues for the nation and the world, and what is your advice on how I can begin to deal with them?'Here are excerpts of some of the responses. "
"Edge's combination of political engagement and blue-sky thinking makes stimulating reading for anyone seeking a glimpse into the next decade."
"Dear W: Scientists Offer
President Advice on Policy"
"There are 84 responses, ranging in topic from advanced nanotechnology to the psychology of foreign cultures, and lots of ideas regarding science, technology, politics, and education."

2002


"What's Your Question?"

"Brockman's thinkers of the 'Third Culture,' whether they, like Dawkins, study evolutionary biology at Oxford or, like Alan Alda, portray scientists on Broadway, know no taboos. Everything is permitted, and nothing is excluded from this intellectual game."
"The responses are generally written in an engaging, casual style (perhaps encouraged by the medium of e-mail), and are often fascinating and thought — provoking.... These are all wonderful, intelligent questions..."

2001—9/11


What Now?


"We are interested in ‘thinking smart,'" declares Brockman on the site, "we are not interested in the anesthesiology of ‘wisdom.'"
"INSPIRED ARENA: Edge has been bringing together the world's foremost scientific thinkers since 1998, and the response to September 11 was measured and uplifting."

2001


"What Questions Have Disappeared?"


"Responses to this year's question are deliciously creative... the variety astonishes. Edge continues to launch intellectual skyrockets of stunning brilliance. Nobody in the world is doing what Edge is doing."
"Once a year, John Brockman of New York, a writer and literary agent who represents many scientists, poses a question in his online journal, The Edge, and invites the thousand or so people on his mailing list to answer it."

2000

"What Is Today's Most Important Unreported Story?"


"Don't assume for a second that Ted Koppel, Charlie Rose and the editorial high command at the New York Times have a handle on all the pressing issues of the day.... a lengthy list of profound, esoteric and outright entertaining responses.

1999

"What Is The Most Important Invention In The Past Two Thousand Years?"



The Greatest Inventions of the Past 2,000 Years
Edited by John Brockman


"A terrific, thought provoking site."
"The Power of Big Ideas"
"The Nominees for Best Invention Of the Last Two Millennia Are . . ."
"...Thoughtful and often surprising answers ....a fascinating survey of intellectual and creative wonders of the world ..... Reading them reminds me of how wondrous our world is." — Bill Gates, New York Times Syndicated Column

1998


"What Questions Are You Asking Yourself?"


"A site that has raised electronic discourse on the Web to a whole new level.... Genuine learning seems to be going on here."
"To mark the first anniversary of [Edge], Brockman posed a question: 'Simply reading the six million volumes in the Widener Library does not necessarily lead to a complex and subtle mind," he wrote, referring to the Harvard library. "How to avoid the anesthesiology of wisdom?' "
"Home to often lively, sometimes obscure and almost always ambitious discussions."



subscribe

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"Astounding reading."


"An unprecedented roster of brilliant minds, the sum of which is nothing short of visionary


"Fantastically stimulating...It's like the crack cocaine of the thinking world.... Once you start, you can't stop thinking about that question."


"Wonderful reading."


"One of the most interesting stopping places on the Web"


"Brilliant! Stimulating reading."


"Today's visions of science tomorrow."


"Fascinating and thought-provoking ...wonderful, intelligent."


"Edge.org...a Web site devoted to dis- cussions of cutting edge science."


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"Everything is permitted, and nothing is excluded from this intellectual game."


"Websites of the year...Inspired Arena...the world's foremost scientific thinkers."


"High concept all the way...the brightest scientists and thinkers ... heady ... deep and refreshing."


" Deliciously crea-tive...the variety astonishes...intel-lectual skyrockets of stunning brill-iance. Nobody in the world is doing what Edge is doing."


"A marvellous showcase for the Internet, it comes very highly recom-mended."


"Profound, esoteric and outright enter-taining."


"A terrific, thought provoking site."


"...Thoughtful and often surprising ...reminds me of how wondrous our world is." — Bill Gates


"One of the Net's most prestigious, invitation-only free trade zones for the exchange of potent ideas."


"An enjoyable read."


"A-list: Dorothy Parker's Vicious Circle without the food and alcohol ... a brilliant format."


"Big, deep and ambitous questions... breathtaking in scope."


"Has raised electronic discourse on the Web to a whole new level."


"Lively, sometimes obscure and almost always ambitious."


MORE PRESS


The Edge Annual Question — 2009

New tools equal new perceptions.

Through science we create technology and in using our new tools we recreate ourselves. But until very recently in our history, no democratic populace, no legislative body, ever indicated by choice, by vote, how this process should play out.

Nobody ever voted for printing. Nobody ever voted for electricity. Nobody ever voted for radio, the telephone, the automobile, the airplane, television. Nobody ever voted for penicillin, antibiotics, the pill. Nobody ever voted for space travel, massively parallel computing, nuclear power, the personal computer, the Internet, email, cell phones, the Web, Google, cloning, sequencing the entire human genome. We are moving towards the redefinition of life, to the edge of creating life itself. While science may or may not be the only news, it is the news that stays news.

And our politicians, our governments? Always years behind, the best they can do is play catch up.

Nobel laureate James Watson, who discovered the DNA double helix, and genomics pioneer J. Craig Venter, recently were awarded Double Helix Awards from Cold Spring Harbor Laboratory for being the founding fathers of human genome sequencing. They are the first two human beings to have their complete genetic information decoded.

Watson noted during his acceptance speech that he doesn't want government involved in decisions concerning how people choose to handle information about their personal genomes.

Venter is on the brink of creating the first artificial life form on Earth. He has already announced transplanting the information from one genome into another. In other words, your dog becomes your cat. He has privately alluded to important scientific progress in his lab, the result of which, if and when realized, will change everything.


WHAT WILL CHANGE EVERYTHING?

"What game-changing scientific ideas and developments do you expect to live to see?"


— John Brockman
Editor and Publisher



- PRESS COVERAGE -






(Science Blog)






"Question was open because it had not yet received any form; it was a kind of prime matter, or a substance that existed in a realm of potentiality, an indefinite state that had not yet become anything in particular and maybe never would. But any formed object, on the other hand, would have denied all that: if it has already received form it is over, closed, ended; it has slid from the vague cloud of potentiality into a collision with the flat wall of fact that lay hidden behind it. " —Thomas McEvilley (Art in America, November, 2008)


James Lee Byars, founder of The World Question Center

James Lee Byars
A Study of Posterity
Though James Lee Byars has been increasingly identified,
since his death, with elegant, reductive objects, his most radical-and characteristic-works were ephemeral and even immaterial.


By Thomas McEvilley

[Continue...]

Further Reading on Edge on James Lee Byars and The World Question Center: "He Confuses One And Two The 200 I.Q.: Mr. Byars By Mr. Brockman" [7.17.97]



- PAGE 1 (BEGIN READING HERE) -

KEVIN KELLY
Editor-At-Large, Wired; Author, New Rules for the New Economy

A NEW KIND OF MIND

It is hard to imagine anything that would "change everything" as much as a cheap, powerful, ubiquitous artificial intelligence — the kind of synthetic mind that learns and improves itself. A very small amount of real intelligence embedded into an existing process would boost its effectiveness to another level. We could apply mindfulness wherever we now apply electricity. The ensuing change would be hundreds of times more disruptive to our lives than even the transforming power of electrification. We'd use artificial intelligence the same way we've exploited previous powers — by wasting it on seemingly silly things. Of course we'd plan to apply AI to tough research problems like curing cancer, or solving intractable math problems, but the real disruption will come from inserting wily mindfulness into vending machines, our shoes, books, tax returns, automobiles, email, and pulse meters.

This additional intelligence need not be super-human, or even human-like at all. In fact, the greatest benefit of an artificial intelligence would come from a mind that thought differently than humans, since we already have plenty of those around. The game-changer is neither how smart this AI is, nor its variety, but how ubiquitous it is. Alan Kay quips in that humans perspective is worth 80 IQ points. For an artificial intelligence, ubiquity is worth 80 IQ points. A distributed AI, embedded everywhere that electricity goes, becomes ai — a low-level background intelligence that permeates the technium, and trough this saturation morphs it.

Ideally this additional intelligence should not be just cheap, but free. A free ai, like the free commons of the web, would feed commerce and science like no other force I can imagine, and would pay for itself in no time. Until recently, conventional wisdom held that supercomputers would first host this artificial mind, and then perhaps we'd get mini-ones at home, or add them to the heads of our personal robots. They would be bounded entities. We would know where our thoughts ended and theirs began.

However, the snowballing success of Google this past decade suggests the coming AI will not be bounded inside a definable device. It will be on the web, like the web. The more people that use the web, the more it learns. The more it knows, the more we use it. The smarter it gets, the more money it makes, the smarter it will get, the more we will use it. The smartness of the web is on an increasing-returns curve, self-accelerating each time someone clicks on a link or creates a link. Instead of dozens of geniuses trying to program an AI in a university lab, there are billion people training the dim glimmers of intelligence arising between the quadrillion hyperlinks on the web. Long before the computing capacity of a plug-in computer overtakes the supposed computing capacity of a human brain, the web — encompassing all its connected computing chips — will dwarf the brain. In fact it already has.

As more commercial life, science work, and daily play of humanity moves onto the web, the potential and benefits of a web AI compound. The first genuine AI will most likely not be birthed in standalone supercomputer, but in the superorganism of a billion CPUs known as the web. It will be planetary in dimensions, but thin, embedded, and loosely connected. Any device that touches this web AI will share — and contribute to — its intelligence. Therefore all devices and processes will (need to) participate in this web intelligence.

Standalone minds are likely to be viewed as handicapped, a penalty one might pay in order to have mobility in distant places. A truly off-the-grid AI could not learn as fast, as broadly, or as smartly as one plugged into 6 billion human minds, a quintillion online transistors, hundreds of exabytes of real-life data, and the self-correcting feedback loops of the entire civilization.

When this emerging AI, or ai, arrives it won't even be recognized as intelligence at first. Its very ubiquity will hide it. We'll use its growing smartness for all kinds of humdrum chores, including scientific measurements and modeling, but because the smartness lives on thin bits of code spread across the globe in windowless boring warehouses, and it lacks a unified body, it will be faceless. You can reach this distributed intelligence in a million ways, through any digital screen anywhere on earth, so it will be hard to say where it is. And because this synthetic intelligence is a combination of human intelligence (all past human learning, all current humans online) and the coveted zip of fast alien digital memory, it will be difficult to pinpoint what it is as well. Is it our memory, or a consensual agreement? Are we searching it, or is it searching us?

While we will waste the web's ai on trivial pursuits and random acts of entertainment, we'll also use its new kind of intelligence for science. Most importantly, an embedded ai will change how we do science. Really intelligent instruments will speed and alter our measurements; really huge sets of constant real time data will speed and alter our model making; really smart documents will speed and alter our acceptance of when we "know" something. The scientific method is a way of knowing, but it has been based on how humans know. Once we add a new kind of intelligence into this method, it will have to know differently. At that point everything changes.


HOWARD GARDNER
Psychologist, Harvard Graduate School of Education; Author, Five Minds for the Future

CRACKING OPEN THE LOCKBOX OF TALENT

What is talent? If you ask the average grade school teacher to identify her most talented student, she is likely to reject the question: "All my students are equally talented." But of course, this answer is rubbish. Anyone who has worked with numerous young people over the years knows that some catch on quickly, almost instantly, to new skills or understandings, while others must go through the same drill, with little depressingly little improvement over time.

As wrongheaded as the teacher's response is the viewpoint put forward by some psychological researchers, and most recently popularized in Malcolm Gladwell's Outliers: The Story of Success. This is notion that there is nothing mysterious about talent, no need to crack open the lockbox: anyone who works hard enough over a long period of time can end up at the top of her field. Anyone who has the opportunity to observe or read about a prodigy — be it Mozart or Yo-Yo Ma in music, Tiger Woods in golf, John von Neumann in mathematics — knows that achievement is not just hard work: the differences between performance at time 1 and successive performances at times 2, 3, and 4 are vast, not simply the result of additional sweat. It is said that if algebra had not already existed,, precocious Saul Kripke would have invented it in elementary school: such a characterization would be ludicrous if applied to most individuals.

For the first time, it should be possible to delineate the nature of talent. This breakthrough will come about through a combination of findings from genetics (do highly talented individuals have a distinctive, recognizable genetic profile?); neuroscience (are there structural or functional neural signatures, and, importantly, can these be recognized early in life?); cognitive psychology (are the mental representations of talented individuals distinctive when contrasted to those of hard workers); and the psychology of motivation (why are talented individuals often characterized as having 'a rage to learn, a passion to master?)

This interdisciplinary scientific breakthrough will allow us to understand what is special about Picasso, Gauss, J.S. Mill. Importantly, it will illuminate whether a talented person could have achieved equally in different domains (could Mozart have been a great physicist? Could Newton have been a great musician?) Note, however, that will not illuminate two other issues:

1.    What makes someone original, creative? Talent, expertise,
       are necessary but not sufficient.
2.    What determines whether talents are applied to constructive
       or destructive ends?

These answers are likely to come from historical or cultural case studies, rather than from biological or psychological science. Part of the maturity of the sciences is an appreciation of which questions are best left to other disciplinary approaches.


TIMOTHY TAYLOR
Archaeologist, University of Bradford; Author, The Buried Soul

CULTURE

Culture changes everything because culture contains everything, in the sense of things that can be named, and so what can be conceived. Wittgenstein implied that what cannot be said cannot be thought. He meant by this that language relies on a series of prior agreements. Such grammar has been shown by anthropologists to underpin the idea of any on-going community, not just its language, but its broader categories, its institutions, its metaphysics. And the same paradox is presented: how can anything new ever happen? If by 'happen' we only think of personal and historical events, we miss the most crucial novelty — the way that new things, new physical objects, devices and techniques, insinuate themselves into our lives. They have new names which we must learn, and new, revolutionary effects.

It does not always work like that. Resistance is common. Paradoxically, the creative force of culture also tries to keep everything the same. Ernest Gellner said that humans, taken as a whole, present the most extensive behavioural variation of any species while every particular cultural community is characterized by powerful norms. These are ways of being that, often through appeals to some apparently natural order, are not just mildly claimed as quintessentially human, but lethally enforced at a local level, in a variety of more or less public ways. Out groups (whether a different ethnicity, class, sexuality, creed, whether being one of twins, an albino, someone disabled or an unusually talented individual) are suspect and challenging in their abnormality. Categories of special difference are typical foci for sacrifice, banishment, and ridicule through which the in-group becomes not just the in-group but, indeed, a distinctly perceptible group, confident, refreshed and culturally reproductive. This makes some sense: aberrance subverts the grammar of culture.

The level at which change can be tolerated varies greatly across social formations, but there is always a point beyond which things become intolerably incoherent. We may rightly label the most unprecedented behaviour mad because, whatever relativization might be invoked to explain it, it is, by definition, strategically doomed: we seek to ignore it. Yet the routine expulsion of difference, apparently critical in the here and now, becomes maladaptive in any longer-term perspective. Clearly, it is change that has created our species' resilience and success, creating the vast inter- (not intra-) cultural diversity that Gellner noted. So how does change happen?

Major change often comes stealthily. Its revolutionary effect may often reside in the very fact that we do not recognize what it is doing to our behaviour, and so cannot resist it. Often we lack to words to articulate resistance as the invention is a new noun whose verbal effect lags in its wake. Such major change operates far more effectively through things than directly through people, not brought about by the mad, but rather by 'mad scientists', whose inventions can be forgiven their inventors.

Unsurprisingly then, the societies that tolerate the least behavioural deviance are the most science-averse. Science, in the broadest sense of effective material invention, challenges quotidian existence. The Amish (a quaint static ripple whose way of life will never uncover the simplest new technological fix for the unfolding hazards of a dynamic universe) have long recognized that material culture embodies weird inspirations, challenging us, as eventual consumers, not with 'copy what I do', but a far, far more subversive 'try me.'

Material culture is the thing that makes us human, driving human evolution from the outset with its continually modifying power. Our species' particular dilemma is that in order to safeguard what we have, we have continually to change. The culture of things — invention and technology — is ever changing under the tide of words and routines whose role is to image fixity and agreement when, in reality, none exists. This form of change is no trivial thing because it is essential to our longer term survival. At least, the longer term survival of anything we may be proud to call universally human


JOHN GOTTMAN
Psychologist; Founder of Gottman Institute; Author (with Julie Gottman), And Baby Makes Three

LABORATORY EARTH COLONIES

The technological changes were small at first. In 2007 a telescope was developed that could search for planets in the Milky Way within 100 light years of Earth. The next version of the telescope in 2008 did not have to block out the light of the new star to see the planets. It could directly see the reflected light of the planets closest to every star. That made it possible to do spectroscopic analysis of reflected light and search for blue planets like Earth. Within a decade, 100 Earth-like planets had been identified within 100 light years. In the next two centuries that number increased to 50,000 blue planets.

Within the next two centuries the seemingly impossible technical problems of space travel began to be solved. Problems of foil sails were solved. Designs emerged for ships that could get up to 85% of the speed of light within 2 years, using acceleration from starts and from harnessing the creative energy of empty space itself. The Moon, Europa and Mars were colonized. Terra-forming technologies developed. Many designs emerged for the spinning complete 2-mile Earth-habitat ship that produced a 1-g environment. Thousands of people wanted to make the trips.

Laboratory Earth colonies were formed for simulating conditions for the galactic trips. Based on these experiments, social scientists soon recognized that the major unsolved problem of galactic colonization was the social psychological problem, How could humans live together for up to 52 years, raising children who would become the explorers of the blue planets? Much had been learned, of course, from the social psychological studies early in the 21st and 22nd Centuries for obtaining planet-wide cooperation in solving global warming and sustainable energy production, and in curing world-wide hunger and disease. But that work was primitive and rudimentary for the challenges of galactic colonization.

The subsequent classic social psychological studies were all funded privately by one man. Thousands of scientists participated. Studies of all kinds were initially devised, and the results were carefully replicated. The entire series of social psychological experiments took a century to perform. It rapidly became clear that a military or any hierarchical social structure could not last without the threats of continual external danger. The work of Peggy Sanday had demonstrated that fact without question. The problem was to foster creative collaboration and minimize self-interest. Eventually, it was deemed necessary for each ship to spend 5 years prior to the trip selecting a problem that all the members would creatively and cooperatively face. The work had to easily consume the crew of a ship for 60 years. In addition, each ship represented a microcosm of all Earth's activities, including all the occupations and professions, adventure, play, and sports.

In the year 2,500 more than 20,000 ships set out, 2 headed for each planet. It was inevitable that many ships would successfully make the journey. No one knew what they would find. There was no plan for communication between the stars. The colonization of the Milky Way had begun.


ED REGIS
Science Writer, Author, What Is Life?

MOLECULAR MANUFACTURING

Nothing has a greater potential for changing everything than the successful implementation of good old-fashioned nanotechnology.

I specify the old-fashioned version because nanotechnology is decidedly no longer what it used to be. Back in the mid-1980s when Eric Drexler first popularized the concept in his book Engines of Creation, the term referred to a radical and grandiose molecular manufacturing scheme. The idea was that scientists and engineers would construct vast fleets of "assemblers," molecular-scale, programmable devices that would build objects of practically any arbitrary size and complexity, from the molecules up. Program the assemblers to put together an SUV, a sailboat, or a spacecraft, and they'd do it — automatically, and without human aid or intervention. Further, they'd do it using cheap, readily-available feedstock molecules as raw materials.

The idea sounds fatuous in the extreme…until you remember that objects as big and complex as whales, dinosaurs, and sumo wrestlers got built in a moderately analogous fashion: they began as minute, nanoscale structures that duplicated themselves, and whose successors then differentiated off into specialized organs and other components. Those growing ranks of biological marvels did all this repeatedly until, eventually, they had automatically assembled themselves into complex and functional macroscale entities. And the initial seed structures, the gametes, were not even designed, built, or programmed by scientists: they were just out there in the world, products of natural selection. But if nature can do that all by itself, then why can't machines be intelligently engineered to accomplish relevantly similar feats?

Latter-day "nanotechnology," by contrast, is nothing so imposing. In fact, the term has been co-opted, corrupted, and reduced to the point where what it refers to is essentially just small-particle chemistry. And so now we have "nano-particles" in products raging from motor oils to sunscreens, lipstick, car polish and ski wax, and even a $420 "Nano Gold Energizing Cream" that its manufacturer claims transports beneficial compounds into the skin. Nanotechnology in this bastardized sense is largely a marketing gimmick, not likely to change anything very much, much less "everything."

But what if nanotechnology in the radical and grandiose sense actually became possible? What if, indeed, it became an operational reality? That would be a fundamentally transformative development, changing forever how manufacturing is done and how the world works. Imagine all of our material needs being produced at trivial cost, without human labor, and with no waste. No more sweat shops, no more smoke-belching factories, no more grinding workdays or long commutes. The magical molecular assemblers will do it all, permanently eliminating poverty in the process.

Then there would be the medical miracles performed by other types of molecular-scale devices that would repair or rejuvenate your body's cells, killing the cancerous or other bad ones, and nudging the rest of them toward unprecedented levels of youth, health, and durability. All without $420 bottles of face cream.

There's a downside to all this, of course, and it has nothing to do with Michael Chrichton-ish swarms of uncontrolled, predatory nanobots hunting down people and animals. Rather, it has to do with the question of what the mass of men and women are going to do when, newly unchained from their jobs, and blessed or cursed with longer life spans, they have oceans of free time to kill. Free time is not a problem for the geniuses and creators. But for the rest of us, what will occupy our idle hands? There is only so much golf you can play.

But perhaps this is a problem that will never have to be faced. The bulk of mainstream scientists pay little attention to radical nanotechnology, regarding its more extravagant claims as science-fictional and beyond belief. Before he died, chemist Richard Smalley, a Nobel prizewinner, made a cottage industry out of arguing that insurmountable technical difficulties at the chemical bonding level would keep radical nanotechnology perpetually in the pipe dream stage. Nobody knows whether he was right about that.

Some people may hope that he was. Maybe changing everything is not so attractive an idea as it seems at first glance.


DOUGLAS RUSHKOFF
Media Analyst; Documentary Writer; Author, Get Back in the Box

THE DISCOVERY OF INTELLIGENT LIFE FROM SOMEWHERE ELSE

We're talking about changing everything — not just our abilities, relationships, politics, economy, religion, biology, language, mathematics, history and future, but all of these things at once. The only single event I can see shifting pretty much everything at once is our first encounter with intelligent, extra-terrestrial life.

The development of any of our current capabilities — genetics, computing, language, even compassion — all feel like incremental advances in existing abilities. As we've seen before, the culmination of one branch of inquiry always just opens the door to a new a new branch, and never yields the wholesale change of state we anticipated. Nothing we've done in the past couple of hundred thousand years has truly changed everything, so I don't see us doing anything in the future that would change everything, either.

No, I have the feeling that the only way to change everything is for something be done to us, instead. Just imagining the encounter of humanity with an "other" implies a shift beyond the solipsism that has characterized our civilization since our civilization was born. It augurs a reversal as big as the encounter of an individual with its offspring, or a creature with its creator. Even if it's the result of something we've done, it's now independent of us and our efforts.

To meet a neighbor, whether outer, inner, cyber- or hyper- spatial, finally turns us into an "us." To encounter an other, whether a god, a ghost, a biological sibling, an independently evolved life form, or an emergent intelligence of our own creation, changes what it means to be human.

Our computers may never inform us that they are self-aware, extra-terrestrials may never broadcast a signal to our SETI dishes, and interdimensional creatures may never appear to those who aren't taking psychedelics at the time — but if any of them did, it would change everything.


JUAN ENRIQUEZ
CEO, Biotechonomy; was Founding Director, Harvard Business School's Life Sciences Project; Author, The Untied States of America

HOMO EVOLUTIS

Speciation is coming. Fast. We keep forgetting that we are but one of several hominids that have walked the Earth (erectus, habilis,neanderthalis, heidelbergensis, ergaster, australopithecus). We keep thinking we are the one and only, the special. But we easily could not have been a dominant species. Or even a species anymore. We blissfully ignore the fact that we came within about 2,000 specimens of going extinct (which is why human DNA is virtually identical).

There is not much evidence, historically, that we are the be all and end all, or that we will remain the dominant species. The fossil history of the planet tells tales of at least six mass extinctions. In each cycle, most life was toast as DNA/RNA hit a reboot key. New species emerged to adapt to new conditions. Asteroid hits? Do away with oceans of slime. World freezes to the Equator? Microbes dominate. Atmosphere fills with poisonous oxygen? no worries, life eventually blurts out obnoxious mammals.

Unless we believe that we have now stabilized all planetary and galactic variables, these cycles of growth and extinction will continue time and again. 99% of species, including all other hominids, have gone extinct. Often this has happened over long periods of time. What is interesting today, 200 years after Darwin's birth, is that we are taking direct and deliberate control over the evolution of many, many species, including ourselves. So the single biggest game changer will likely be the beginning of human speciation. We will begin to get glimpses of it in our lifetime. Our grandchildren will likely live it.

There are at least three parallel tracks on which this change is running towards us. The easiest to see and comprehend is taking place among the "handicapped." As we build better prostheses, we begin to see equality. Legless Oscar Pistorious attempting to put aside the Special Olympics and run against able bodied Olympians is but one example. In Beijing he came very close, but did not meet the qualifying times. However, as materials science, engineering, and design advance, by next Olympics he and his disciples will be competitive. And one Olympics after that the "handicapped" could be unbeatable.

It's not just limbs, what started out as large cones for the hard of hearing eventually became pesky, malfunctioning hearing aids. Then came discrete, effective, miniaturized buds. Now internally implanted cochlear implants allow the deaf to hear. But unlike natural evolution, which requires centuries, digital technologies double in power and halve in price every few months. Soon those with implants will hear as well as we do, and, a few months after that, their hearing may be more acute than ours. Likely the devices will span a broad and adjustable tonal range, including that of species like dogs, bats, or dolphins. Wearers will be able to adapt to various environments at will. Perhaps those with natural hearing will file discrimination lawsuits because they were not hired by symphony orchestras…

Speciation does not have to be mechanical, there is a second parallel, fast moving, track in stem cell and tissue engineering. While the global economy melted down this year, a series of extraordinary discoveries opened interesting options that will be remembered far longer that the current NASDAQ index. Labs in Japan and Wisconsin rebooted skin cells and turned them into stem cells. We are now closer to a point where any cell in our body can be rebooted back to its original factory settings (pluripotent stem cell) and can rebuild any part of our body. At the same time, a Harvard team stripped a mouse heart of all its cells, leaving only cartilage. The cartilage was covered in mouse stem cells, which self organized into a beating heart. A Wake Forest group was regrowing human bladders and implanting them into accident and cancer victims. By year end, a European team had taken a trachea from a dead donor, taken the cells off, and then covered the sinew with bone marrow cells taken from a patient dying of tuberculosis. These cells self organized and regrew a fully functional trachea which was implanted into the patient. There was no need for immunosuppressants; her body recognized the cells covering the new organ as her own…

Again, this is an instance where treating the sick and the needy can quickly expand into a "normal" population with elective procedures. The global proliferation of plastic surgery shows how many are willing to undergo great expense, pain, and inconvenience to enhance their bodies. Between 1996 and 2002 elective cosmetic surgery increased 297%, minimally invasive procedures increased 4146%. As artificial limbs, eyes, ears, cartilage begin to provide significant advantages, procedures developed to enhance the quality of life for the handicapped may become common.

After the daughter of one of my friends tore her tendons horseback riding, doctors told her they would have to harvest parts of her own tendons and hamstrings to rebuild her leg. Because she was so young, the crippling procedure would have to be repeated three times as her body grew. But her parents knew tissue engineers were growing tendons in a lab, so she was one of the first recipients of a procedure that allows natural growth and no harvesting. Today she is a successful ski racer, but her coach feels her "damaged" knee is far stronger and has asked whether the same procedure could be done on the undamaged knee…

As we regrow or engineer more body parts we will likely significantly increase average life span and run into a third track of speciation. Those with access to Google already have an extraordinary evolutionary advantage over the digitally illiterate. Next decade we will be able to store everything we see, read, and hear in our lifetime. The question is can we re-upload and upgrade this data as the basic storage organ deteriorates? And can we enhance this organ's cognitive capacity internally and externally? MIT has already brought together many of those interested in cognition — neuroscientists, surgeons, radiologists, psychologists, psychiatrists, computer scientists — to begin to understand this black box. But rebooting other body parts will likely be easier than rebooting the brain, so this will likely be the slowest track but, over the long term, the one with the greatest speciation impact.

Speciation will not be a deliberate, programmed event. Instead it will involve an ever faster accumulation of small, useful improvements that eventually turn homo sapiens into a new hominid. We will likely see glimpses of this long-lived, partly mechanical, partly regrown creature that continues to rapidly drive its own evolution. As the branches of the tree of life, and of hominids, continue to grow and spread, many of our grandchildren will likely engineer themselves into what we would consider a new species, one with extraordinary capabilities, a homo evolutis.


ROGER C. SCHANK
Psychologist & Computer Scientist; Engines for Education Inc.; Author, Making Minds Less Well Educated Than Our Own

WISDOM REBORN

An executive of a consumer products company who I know was worrying about how to make the bleach his company produces better. He thought it would be nice if the bleach didn't cause "collateral damage." That is, he wanted it to harm bad stuff without harming good stuff. He seized upon the notion of collateral damage and began to wonder where else collateral damage was a problem. Chemotherapy came to mind and he visited some oncologists who gave him some ideas about what they did to make chemotherapy less harmful tp patients. He then applied those same ideas to improve his company's bleach.

He began to wonder about what he had done and how he had done it. He wanted to be able to do this sort of thing again. But what is this sort of thing and how can one do it again?

In bygone days we lived in groups that had wise men (and women) who told stories to younger people if they thought that those stories might be relevant to their needs. This was called wisdom and teaching and it served as way of passing one generation's experiences to the next.

We have lost this ability to some extent because we live in a much larger world, where the experts are not likely to be in the next cave over and where there is a lot more to have expertise about. Nevertheless, we, as humans, are set up to deliver and make use of just in time wisdom. We just aren't that sure where to find it. We have created books, and schools, and now search engines to replace what we have lost. Still it would be nice if there was wisdom to be had without having to look hard to find it.

Those days of just in time storytelling will return. The storyteller will be your computer. The computers we have today are capable of understanding your needs and finding just the right (previously archived and indexed) wise man (or woman) to tell you a story, just when you need it, that will help you think something out. Some work needs to be done to make this happen of course.

No more looking for information. No more libraries. No more key words. No more search engines.

Information will find you, and just in the nick of time. And this will "change everything."

You are seeing the beginning of this today, but it is being done in a mindless and commercial way, led of course by Google ads that watch the words you type and match them to ads they have written that contain those words. (I receive endless offers of on line degrees, for example, because that is what I often write about.) Three things will change:

1. The information that finds you will be relevant and important to what you are working on and will arrive just in time.
2. The size of information will change. No more books-worth amount of information (book size is an artifact of what length books sells — there are no ten page books.)
3. A new form of publishing will arrive that serves to vet the information you receive. Experts will be interviewed and their best stories will be indexed. Those stories will live forever waiting for someone to tell them to at the right moment.

In the world that I am describing the computer has to know what you are trying to accomplish, not what words you just typed, and it needs to have an enormous archive of stories to tell you. Additionally it needs to have indexed all the stories it has in its archives to activities you are working on in such a way that the right story comes up at the right time.

What needs to happen to make this a reality? Computers need an activity model. They need to know what you are doing and why. As software becomes more complex and more responsible for what we do in our daily lives, this state of affairs is inevitable.

An archive needs to be created that has all the wisdom of the world in it. People have sought to do this for years, in the form of encyclopedias and such, but they have failed to do what was necessary to make those encyclopedias useful. There is too much in a typical encyclopedia entry, not to mention the absurd amount of information in a book. People are set up to hear stories and stories don't last all that long before we lose our ability to concentrate on their main point, their inherent wisdom, if you will. People tell each other stores all the time, but when they write or lecture they are permitted (or encouraged) to go on way too long (as I am doing now.)

Wisdom depends upon goal directed prompts that say what to do when certain conditions are encountered. To put this another way, an archive of key strategic ideas about how to achieve goals under certain conditions is just the right resource to be interacting with enabling a good story to pop up when you need it. The solution involves goal-directed indexing. Ideas such a "collateral damage" are indices to knowledge. We are not far from the point where computers will be able to recognize collateral damage when it happens and find other examples that help you think something out.

Having a "reminding machine" that gets reminding of universal wisdom as needed will indeed change everything. We will all become much more likely to profit from humanity's collective wisdom by having a computer at the ready to help us think.


STUART KAUFFMAN
Director, The Institute for Biocomplexity and Informatics, The University of Calgary; Author, Reinventing the Sacred

THE OPEN UNIVERSE

John Brockman's question is dramatic: What will change everything? Of course, no one knows. But the fact that no one knows may be the feature of our lives and the universe that does change everything. Reductionism has reigned as our dominant world view for 350 years in Western society. Physicist Steven Weinberg states that when the science shall have been done, all the explanatory arrows will point downward, from societies to people, to organs, to cells, to biochemistry, to chemistry and ultimately to physics and the final theory.

I think he is wrong: the evolution of the biosphere, the economy, our human culture and perhaps aspects of the abiotic world, stand partially free of physical law and are not entailed by fundamental physics. The universe is open.

Many physicists now doubt the adequacy of reductionism, including Philip Anderson, and Robert Laughlin. Laughlin argues for laws of organization that need not derive from the fundamental laws of physics. I give one example. Consider a sufficiently diverse collection of molecular species, such as peptides, RNA, or small molecules, that can undergo reactions and are also candidates to catalyze those very reactions. It can be shown analytically that at a sufficient diversity of molecular species and reactions, so many of these reactions are expected to be catalyzed by members of the system that a giant catalyzed reaction network arises that is collectively autocatalytic. It reproduces itself.

The central point about the autocatalytic set theory is that it is a mathematical theory, not reducible to the laws of physics, even if any specific instantiation of it requires actual physical "stuff". It is a law of organization that may play a role in the origin of life.

Consider next the number of proteins with 200 amino acids: 20 to the 200th power. Were the 10 to the 80th particles in the known universe doing nothing but making proteins length 200 on the Planck time scale, and the universe is some 10 to the 17th seconds old, it would require 10 to the 39th lifetimes of the universe to make all possible proteins length 200 just once. But this means that, above the level of atoms, the universe is on a unique trajectory. It is vastly non-ergodic. Then we will never make all complex molecules, organs, organisms, or social systems.

In this second sense, the universe is indefinitely open "upward" in complexity.

Consider the human heart, which evolved in the non-ergodic universe. I claim the physicist can neither deduce nor simulate the evolutionary becoming of the heart. Simulation, given all the quantum throws of the dice, for example cosmic rays from somewhere mutating genes, seems out of the question. And were such infinitely or vastly many simulations carried out there would be no way to confirm which one captured the evolution of this biosphere.

Suppose we asked Darwin the function of the heart. "Pumping blood" is his brief reply. But there is more. Darwin noted that features of an organism of no selective use in the current environment might be selected in a different environment. These are called Darwinian "preadaptations" or "exaptations". Here is an example: Some fish have swim bladders, partially filled with air and partially with water, that adjust neutral bouyancy in the water column. They arose from lung fish. Water got into the lungs of some fish, and now there was a sac partially filled with air, partially filled with water, poised to become a swim bladder. Three questions arise: Did a new function arise in the biosphere? Yes, neutral bouyancy in the water column. Did it have cascading consequences for the evolution of the biosphere? Yes, new species, proteins and so forth.

Now comes the essential third question: Do you think you could say ahead of time all the possible Darwinian preadaptations of all organisms alive now, or just for humans? We all seem to agree that the answer is a clear "No". Pause. We cannot say ahead of time what the possible preadaptations are. As in the first paragraph, we really do not know what will happen. Part of the problem seems to be that we cannot prespecify all possible selective environments. How would we know we had succeeded? Nor can we prespecify the feature(s) of one or several organisms that might become preadaptations.

Then we can make no probability statement about such preadaptations: We do not know the space of possibilities, the sample space, so can construct no probability measure.

Can we have a natural law that describes the evolution of the swim bladder? If a natural law is a compact description available beforehand, the answer seems a clear No. But then it is not true that the unfolding of the universe is entirely describable by natural law. This contradicts our views since Descartes, Galileo and Newton. The unfolding of the universe seems to be partially lawless. In its place is a radically creative becoming.

Let me point to the Adjacent Possible of the biosphere. Once there were lung fish, swim bladders were in the Adjacent Possible of the biosphere. Before there were multicelled organisms, the swim bladder was not in the Adjacent Possible of the biosphere. Something wonderful is happening right in front of us: When the swim bladder arose it was of selective advantage in its context. It changed what was Actual in the biosphere, which in turn created a new Adjacent Possible of the biosphere. The biosphere self consistently co-constructs itself into its every changing, unstatable Adjacent Possible.

If the becoming of the swim bladder is partially lawless, it certainly is not entailed by the fundamental laws of physics, so cannot be deduced from physics. Then its existence in the non-ergodic universe requires an explanation that cannot be had by that missing entailment. The universe is open.

Part of the explanation rests in the fact that life seems to be evolving ever more positive sum games. As organismic diversity increases, and the "features" per organism increase, there are more ways for selection to select for mutualisms that become the conditions of joint existence in the universe. The humming bird, sticking her beak in the flower for nectar, rubs pollen off the flower, flies to a next flower for nectar, and pollen rubs off on the stamen of the next flower, pollinating the flower. But these mutualistic features are the very conditions of one another's existence in the open universe. The biosphere is rife with mutualisms. In biologist Scott Gilbert's fine phrase, these are codependent origination — an ancient Buddhist phrase. In this open universe, beyond entailment by fundamental physics, we have partial lawlessness, ceaseless creativity, and forever co-dependent origination that changes the Actual and the ever new Adjacent Possible we ceaselessly self-consistently co-construct. More, the way this unfolds is neither fully lawful, nor is it random. We need to re-envision ourselves and the universe.


KARL SABBAGH
Writer and Television Producer; Author, The Riemann Hypothesis

A FAREWELL TO HARM

Much of the misery in the world today — as it always has been — is due to the human propensity to contemplate, or actually commit, violence against another human being. It's not just assaults and murders that display that propensity. Someone who designs a weapon, punishes a child, declares war or leaves a hit-and-run victim by the side of the road has defined 'harming another human being' as a justifiable action for himself. How different the world would be if, as a biologically determined characteristic of future human beings, there was such a cognitive inhibition to such actions that people would be incapable of carrying them out, just as most of us are incapable of moving our ears.

It must be the case that that in the brains of everyone, from abusive parents and rapists to arms dealers and heads of state, there can arise a concatenation of nerve impulses which allow someone to see as 'normal' — or at least acceptable — the mutilation, maiming or death of another for one's own pleasure, greed or benefit. Suppose the pattern of that series of impulses was analysable exactly, with future developments of fMRI, PET scans or technology as yet uninvented. Perhaps every decision to kill or harm another person can be traced to a series of nerve impulses that arise in brain centre A, travel in a microsecond to areas B, C, and D, inhibit areas E and F, and lead to a previously unacceptable decision becoming acceptable. Perhaps we would discover a common factor between the brain patterns of someone who is about to murder a child, and a head of state signing a bill to initiate a nuclear weapons programme, or an engineer designing a new type of cluster bomb. All of them accept at some intellectual level that it is perfectly all right for their actions to cause harm or death to another human. The brains of all of them, perhaps, experience pattern D, the 'death pattern'.

If such a specific pattern of brain activity were detectable, could methods then be devised that prevented or disrupted it whenever it was about to arise? At its most plausible — and least socially acceptable — everyone could wear microcircuit-based devices that detected the pattern and suppressed or disrupted it, such that anyone in whom the impulse arose would instantaneously lose any will to carry it out. Less plausible, but still imaginable, would be some sophisticated chemical suppressant of 'pattern D', genetically engineered to act at specific synapses or on specific neurotransmitters, and delivered in some way that reached every single member of the world's population. The 'pattern D suppressant' could be used as a water additive, like chlorine, acceptable now to prevent deaths from dirty water; or as inhalants sprayed from the air; or in genetically modified foodstuffs; even, perhaps, alteration of the germ cell line in one generation that would forever remove pattern D from future generations.

Rapes would be defused before they happened; soldiers — if there were still armies — would be inhibited from firing as their trigger fingers tightened, except of course there would be no one to fire at since enemy soldiers, insurgents, or terrorists would themselves be unable to carry their violent acts to completion.

Would the total elimination of murderous impulses from the human race have a down side? Well, of course, one single person who escaped the elimination process could then rule the world. He — probably a man — could oppress and kill with impunity since no one else would have the will to kill him. Measures would have to be devised to deal with such a situation. Such a person would be so harmful to the human race that, perhaps, plans would have to be laid to control him if he should arise. Tricky, this one, since he couldn't be killed, as there would no one able to kill him or even to design a machine that would kill him, as that also would involve an ability to contemplate the death of another human being.

But setting that possibility aside, what would be the disadvantages of a world in which, chemically or electronically, the ability to kill or harm another human being would be removed from all people? Surely, only good could come from it. Crimes motivated by greed would still be possible, but robberies would be achieved with trickery rather than at the point of a pistol; gang members might attack each other with insults and taunts rather than razors or coshes; governments might play chess to decide on tricky border issues; and deaths from road accidents would go down because even the slightest thought about one's own behaviour causing the death of another would be so reminiscent of 'pattern D' that we would all drive much more carefully to avoid it. Deaths from natural disasters would continue, but charitable giving and international aid in such situations would soar as people realised that not helping to prevent them in future would be almost as bad as the old and now eliminated habit of killing people.

A method to eliminate 'pattern D' will lead to the most significant change ever in the way humans — and therefore societies — behave. And somewhere, in the fields of neurobiology or genetic modification today the germ of that change may already be present.



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MARC D. HAUSER
Psychologist and Biologist, Harvard University: Author, Moral Minds

THE ACTUAL, THE POSSIBLE, AND THE UNIMAGINABLE

Science fiction writers traffic in a world that tries on possible worlds. What if, as in the Hollywood blockbuster Minority Report, we could read people's intentions before they act and thus preempt violence? An intentionality detector would be a terrific device to have, but talk about ethical nightmares. If you ever worried about big brother tapping your phone lines, how about tapping your neural lines? What about aliens from another planet? What will they look like? How do they reproduce? How do they solve problems? If you want to find out, just go back and watch reruns of Star Trek, or get out the popcorn and watch Men In Black, War of the Worlds, The Thing, Signs, and The Blob.

But here's the rub on science fiction: it's all basically the same stuff, one gimmick with a small twist. Look at all the aliens in these movies. They are always the same, a bit wispy, often with oversized heads, see through body parts, and with awesome powers. And surprisingly, this is how it has been for 75 or so years of Hollywood, even though our technologies have greatly expanded the range of special effects that are possible. Why the lack of creativity? Why such a poverty of the imagination?

The answer is simple, and reveals a deep fact about our biology, and the biology of all other organisms. The brain, as a physical device, evolved to process information and make predictions about the future. Though the generative capacity of the brain, especially the human brain, is spectacular — providing us with a system for massive creativity, it is also highly constrained. The constraints arise from both the physics of brain operation, as well as the requirements of learnability.

These constraints establish what we, and other organisms have achieved — the actual — and what they could, in the future and with the right conditions, potentially achieve — the possible. Where things get interesting is in thinking about the unimaginable. Poof! But there is a different way of thinking about this problem that takes advantage of exciting new developments in molecular biology, evolutionary developmental biology, morphology, neurobiology, and linguistics. In a nutshell, for the first time we have a science that enables us to understand the actual, the possible and the unimaginable, a landscape that will forever change our understanding of what it means to be human, including how we arrived at our current point in evolutionary theory, and where might end up in ten or ten million years.

To illustrate, consider a simple example from the field of theoretical morphology, a discipline that aims to map out the space of possible morphologies and in so doing, reveal not only why some parts of this space were never explored, but also why they never could be explored. The example concerns an extinct group of animals called the ammonoids, swimming cephalopod mollusks with a shell that spirals out from the center before opening up.

In looking at the structure of their shells — the ones that actually evolved that is — there are two relevant dimensions that account for the variation: the rate at which the spiral spirals out and the distance between the center of this coil or spiral and the opening. If you plot the actual ammonoid species on a graph that includes spiral rate and distance to the opening, you see a density of animals in a few areas, and then some gaps. The occupied spaces in this map show what actually evolved, whereas the vacant spaces suggest either possible (not yet evolved) or impossible morphologies.

Of great interest in this line of research is the cause of the impossible. Why, that is, have certain species never taken over a particular swath of morphological turf? What is it about this space that leaves it vacant? Skipping many details, some of the causes are intrinsic to the organisms (e.g., no genetic material or developmental programs for building wheels instead of legs) and some extrinsic (e.g., circles represent an impossible geometry or natural habitats would never support wheels).

What is exciting about these ideas is that they have a family resemblance to those that Noam Chomsky mapped out over 50 years ago in linguistics. That is, the biology that allows us to acquire a range of possible languages, also puts constraints on this system, leaving in its wake a space of impossible languages, those that could never be acquired or if acquired, would never remain stable. And the same moves can be translated into other domains of cultural expression, including music, morality, and mathematics. Are there musical scores that no one, not even John Cage, could dream up because the mind can't fathom certain frequencies and temporal arrangements? Are there evolvable moral systems that we will never see because our current social systems and environments make these toxic to our moral sensibilities? Regardless of how these questions are resolved, they open up new research opportunities, using methods that are only now being refined.

Here are some of my favorites, examples that reveal how we can extend the range of the possible, invading into the terra incognita of the impossible. Thanks to work by neuroscientists such as Evan Balaban, we now know that we can combine the brain parts of different animals to create chimeras. For example, we can take the a part of a quail's brain and pop it into a chicken and when the young chick develops, it head bobs like a quail and crows like a chicken.

Functionally, we have allowed the chicken to invade an empty space of behavior, something unimaginable, to a chicken that is. Now let your imagination run wild. What would a chimpanzee do with the generative machinery that a human has when it is running computations in language, mathematics and music? Could it imagine the previously unimaginable? What if we gave a genius like Einstein the key components that made Bach a different kind of genius? Could Einstein now imagine different dimensions of musicality? These very same neural manipulations are now even possible at the genetic level. Genetic engineering allows us to insert genes from one species into another, or manipulate the expressive range of a gene, jazzing it up or turning it off.

This revolutionary science is here, and it will forever change how we think. It will change what is possible, potentially remove what is possible but deleterious, and open our eyes to the previously impossible.


RODNEY BROOKS
Roboticist, on leave from MIT, co-founder of iRobot, CTO and Chairman of Heartland Robotic, author, Flesh and Machines

LIFE (OR NOT) ON MARS

I am very sure that in my lifetime we will have a definitive answer to one question that has been debated, with little data, for hundreds of years. The answer as to whether or not there is life on Mars will either be a null result if negative, or it will profoundly impact science (and perhaps philosophy and religion) if positive.

As 90's Administrator of NASA Dan Goldin rightly reasoned the biggest possible positive public relations coup for his agency, and therefore for its continued budget, would be if it discovered unambiguous evidence of life somewhere elsewhere in the Universe, besides on Earth.

One of the legacies we see today of that judgment is the almost weekly flow of new planets being discovered orbiting nearby stars. If life does exist outside of our solar system the easy bet is that it exists on planets, so we better find planets to look at for direct evidence of life. We have been able to infer the existence of very large planets by carefully measuring star wobbles, and more recently we have detected smaller planets by measuring their occultations, the way they dim a star as they cross between it and Earth. And just in the last months of 2008 we have our first direct images of planets orbiting other stars.

NASA has an ambitious program using the Hubble and Spitzer space telescopes and the 2016 launch of the Terrestial Planet Finder to get higher and higher resolution images of extra-solar planets and look for tell-tale chemical signatures of large scale biochemical impact of Earth-like life on these planets. If we do indeed discover life elsewhere through these methods it will have an large impact on our views of the life, and will no doubt stimulate much creative thinking which will lead to new science about Earth-life. But it will take a long, long, time to infer many details about the nature of that distant life and the detailed levels of similarities and differences to our own versions of life.

The second of Goldin's legacies is about life much closer to home. NASA has a strong, but somewhat endangered at this moment, direct exploration program for the surface of Mars. We have not yet found direct evidence of life there, but neither have the options for its existence narrowed appreciably. And we are very rapidly learning much more about likely locations for life; again just in the last months of 2008 we have discovered vast water glaciers with just a shallow covering of soil. We have many more exciting places to go look for life on Mars than we will be able to send probes over the next handful of years. If we do discover life on Mars (alive or extinct) one can be sure that there will be a flurry of missions to go and examine the living entities or the remnants in great detail.

There are a range of possible outcomes for what life might look like on Mars, and it may leave ambiguity of whether its creation was a spontaneous event independent of that on Earth or whether there has been cross contamination of our two planets with only one genesis for life.

At one extreme life on Mars could turn out to be DNA-based with exactly the same coding scheme for amino acids that all life on Earth uses. Or it could look like a precursor to Earth life, again sharing a compatible precursor encoding, perhaps an RNA-based life form, or even an PNA-based (Peptide Nucleic Acid) form. Any of these outcomes would help us immensely in our understanding of the development of life from non-life, whether it happened on Mars or Earth.

Another set of possibilities for what we might discover would be one of these same forms with a different or incompatible encoding for amino acids. That would be a far more radical outcome. It would tell us two things. Life arose twice, spontaneously and separately, on two adjacent planets in one particular little solar system. The Universe must in that case be absolutely teeming with life. But more than that it would say that the space of possible life biochemistries is probably rather narrow, so we will immediately know a lot about all those other life forms out there. And it will inform us about the probable spaces that we should be searching in our synthetic biology efforts to build new life forms.

The most mind expanding outcome would be if life on Mars is not at all based on a genetic coding scheme of long chains of purine bases that decode in triples to select an amino acid to be tacked on to a protein under construction. This would revolutionize our understanding of the possibilities for biology. It would provide us with a completely different form to study. It would open the possibilities for what must be invariant in biology and what can be manipulated and engineered. It would completely change our understanding of ourselves and our Universe.


MARCELO GLEISER
Appleton Professor of Natural Philosophy, Dartmouth College; Author, The Prophet and the Astronomer: Apocalyptic Science and the End of the World

MASTERING DEATH

There is no question more fundamental to us than our mortality. We die and we know it. It is a terrifying, inexorable truth, one of the few absolute truths we can count on. Other noteworthy absolute truths tend to be mathematical, such as in 2+2=4. Nothing horrified the French philosopher and mathematician Blaise Pascal more than "the silence of infinitely open spaces," the nothingness that surrounds the end of time and our ignorance of it.

For death is the end of time, the end of experience. Even if you are religious and believe in an afterlife, things certainly are different then: either you exist in a timeless Paradise (or Hell), or as some reincarnate soul. If you are not religious, death is the end of consciousness. And with consciousness goes the end of tasting a good meal, reading a good book, watching a pretty sunset, having sex, loving someone. Pretty grim in either case.

We only exist while people remember us. I think of my great-grandparents in nineteenth-century Ukraine. Who were they? No writings, no photos, nothing. Just their genes remain, diluted, in our current generation.

What to do? We spread our genes, write books and essays, prove theorems, invent family recipes, compose poems and symphonies, paint and sculpt, anything to create some sort of permanence, something to defy oblivion. Can modern science do better? Can we contemplate a future when we control mortality? I know I am being way too optimistic considering this a possibility, but the temptation to speculate is far too great for me to pass on it. Maybe I'll live for 101 years like Irving Berlin, having still half of my life ahead of me.

I can think of two ways in which mortality can be tamed. One at the cellular level and the other through an integration of body with genetic, cognitive sciences, and cyber technology. I'm sure there are others. But first, let me make clear that at least according to current science, mortality could never be completely stopped. Speculations aside, modern physics forbids time travel to the past. Unfortunately, we can't just jump into a time machine to relive our youth over and over again. (Sounds a bit horrifying, actually.)

Causality is an unforgiving mistress. Also, unless you are a vampire (and there were times in my past when I wished I were one) and thus beyond submitting to the laws of physics, you can't really escape the second law of thermodynamics: even an open system like the human body, able to interact with its external environment and absorb nutrients and energy from it, will slowly deteriorate. In time, we burn too much oxygen. We live and we rust. Herein life's cruel compromise: we need to eat to stay alive. But by eating we slowly kill ourselves.

At the cellular level, the mitochondria are the little engines that convert food into energy. Starving cells live longer. Apparently, proteins from the sirtuin family contribute to this process, interfering with normal apoptosis, the cellular self-destruction program.

Could the right dose of sirtuin or something else be found to significantly slow down aging in humans? Maybe, in a few decades… Still at the cellular level, genetic action may also interfere with the usual mitochondrial respiration. Reduced expression of the mclk1 gene has been shown to slow down aging in mice. Something similar was shown to happen in C. Elegans worms. The results suggest that the same molecular mechanism for aging is shared throughout the animal kingdom.

We can speculate that, say, by 2040, a combination of these two mechanisms may have allowed scientists to unlock the secrets of cellular aging. It's not the elixir of life that alchemists have dreamt of, but the average life span could possibly be increased to 125 years or even longer, a significant jump from the current US average of about 75 years. Of course, this would create a terrible burden on social security. But retirement age by then would be around 100 or so.

A second possibility is more daring and probably much harder to become a reality within my next 50 or so years of life. Combine human cloning with a mechanism to store all our memories in a giant database. Inject the clone of a certain age with the corresponding memories. Voilà! Will this clone be you? No one really knows. Certainly, just the clone without the memories won't do. We are what we remember.

To keep on living with the same identity, we must keep on remembering. Unless, of course, you don't like yourself and want to forget the past. So, assuming such tremendous technological jump is even feasible, we could migrate to a new copy of ourselves when the current one gets old and rusty. Some colleagues are betting such technologies will become available within the century.

Although I'm an optimist by nature, I seriously doubt it. I probably will never know, and my colleagues won't either. However, there is no question that controlling death is the ultimate human dream, the one "thing that can change everything else." I leave the deeply transforming social and ethical upheaval this would cause to another essay. Meanwhile, I take advice from Mary Shelley's Frankenstein. Perhaps there are things we are truly unprepared for.


NICK BOSTROM
Philosopher, University of Oxford; Editor, Human Enhancement

SUPERINTELLIGENCE

Intelligence is a big deal. Humanity owes its dominant position on Earth not to any special strength of our muscles, nor any unusual sharpness of our teeth, but to the unique ingenuity of our brains. It is our brains that are responsible for the complex social organization and the accumulation of technical, economic, and scientific advances that, for better and worse, undergird modern civilization.

All our technological inventions, philosophical ideas, and scientific theories have gone through the birth canal of the human intellect. Arguably, human brain power is the chief rate-limiting factor in the development of human civilization.

Unlike the speed of light or the mass of the electron, human brain power is not an eternally fixed constant. Brains can be enhanced. And, in principle, machines can be made to process information as efficiently as — or more efficiently than — biological nervous systems.

There are multiple paths to greater intelligence. By "intelligence" I here refer to the panoply of cognitive capacities, including not just book-smarts but also creativity, social intuition, wisdom, etc.

Let's look first at how we might enhance our biological brains. There are of course the traditional means: education and training, and development of better methodologies and conceptual frameworks. Also, neurological development can be improved through better infant nutrition, reduced pollution, adequate sleep and exercise, and prevention of diseases that affect the brain. We can use biotech to enhance cognitive capacity, by developing pharmaceuticals that improve memory, concentration, and mental energy; or we could achieve these ends with genetic selection and genetic engineering. We can invent external aids to boost our effective intelligence — notepads, spreadsheets, visualization software.

We can also improve our collective intelligence. We can do so via norms and conventions — such as the norm against using ad hominem arguments in scientific discussions — and by improving epistemic institutions such the scientific journal, anonymous peer review, and the patent system. We can increase humanity's joint problem-solving capacity by creating more people or by integrating a greater fraction of the world's existing population into productive endeavours, and we can develop better tools for communication and collaboration — various internet applications being recent examples.

Each of these ways of enhancing individual and collective human intelligence holds great promise. I think they ought to be vigorously pursued. Perhaps the smartest and wisest thing the human species could do would be to work on making itself smarter and wiser.

In the longer run, however, biological human brains might cease to be the predominant nexus of Earthly intelligence.

Machines will have several advantages: most obviously, faster processing speed — an artificial neuron can operate a million times faster than its biological counterpart. Machine intelligences may also have superior computational architectures and learning algorithms. These "qualitative" advantages, while harder to predict, may be even more important than the advantages in processing power and memory capacity. Furthermore, artificial intellects can be easily copied, and each new copy can — unlike humans — start life fully-fledged and endowed with all the knowledge accumulated by its predecessors. Given these considerations, it is possible that one day we may be able to create "superintelligence": a general intelligence that vastly outperforms the best human brains in every significant cognitive domain.

The spectrum of approaches to creating artificial (general) intelligence ranges from completely unnatural techniques, such as those used in good old-fashioned AI, to architectures modelled more closely on the human brain. The extreme of biological imitation is whole brain emulation, or "uploading". This approach would involve creating a very detailed 3d map of an actual brain — showing neurons, synaptic interconnections, and other relevant detail — by scanning slices of it and generating an image using computer software. Using computational models of how the basic elements operate, the whole brain could then be emulated on a sufficiently capacious computer.

The ultimate success of biology-inspired approaches seems more certain, since they can progress by piecemeal reverse-engineering of the one physical system already known to be capable of general intelligence, the brain. However, some unnatural or hybrid approach might well get there sooner.

It is difficult to predict how long it will take to develop human-level artificial general intelligence. The prospect does not seem imminent. But whether it will take a couple of decades, many decades, or centuries, is probably not something that we are currently in a position to know. We should acknowledge this uncertainty by assigning some non-trivial degree of credence to each of these possibilities.

However long it takes to get from here to roughly human-level machine intelligence, the step from there to superintelligence is likely to be much quicker. In one type of scenario, "the singularity hypothesis", some sufficiently advanced and easily modifiable machine intelligence (a "seed AI") applies its wits to create a smarter version of itself. This smarter version uses its greater intelligence to improve itself even further. The process is iterative, and each cycle is faster than its predecessor. The result is an intelligence explosion. Within some very short period of time — weeks, hours — radical superintelligence is attained.

Whether abrupt and singular, or more gradual and multi-polar, the transition from human-level to superintelligence would of pivotal significance. Superintelligence would be the last invention biological man would ever need to make, since, by definition, it would be much better at inventing than we are. All sorts of theoretically possible technologies could be developed quickly by superintelligence — advanced molecular manufacturing, medical nanotechnology, human enhancement technologies, uploading, weapons of all kinds, lifelike virtual realities, self-replicating space-colonizing robotic probes, and more. It would also be super-effective at creating plans and strategies, working out philosophical problems, persuading and manipulating, and much else beside.

It is an open question whether the consequences would be for the better or the worse. The potential upside is clearly enormous; but the downside includes existential risk. Humanity's future might one day depend on the initial conditions we create, in particular on whether we successfully design the system (e.g., the seed AI's goal architecture) in such a way as to make it "human-friendly" — in the best possible interpretation of that term.


WILLIAM CALVIN
Neuroscientist, University of Washington School of Medicine; Author, Global Fever

CLIMATE WILL CHANGE EVERYTHING

Climate will change our worldview. That each of us will die someday ranks up there with 2+2=4 as one of the great certainties of all time. But we are accustomed to think of our civilization as perpetual, despite all of the history and prehistory that tells us that societies are fragile. The junior-sized slices of society such as the church or the corporation, also assumed to outlive the participant, provide us with everyday reminders of bankruptcy. Climate change is starting to provide daily reminders, challenging us to devise ways to build in resiliency, an ability to bounce back when hit hard.

Climate may well force on us a major change in how science is distilled into major findings. There are many examples of the ponderous nature of big organizations and big projects. While I think that the IPCC deserves every bit of its hemi-Nobel, the emphasis on "certainty" and the time required for a thousand scientists and a hundred countries to reach unanimous agreement probably added up to a considerable delay in public awareness and political action.

Climate will change our ways of doing science, making some areas more like medicine with its combination of science and interventional activism, where delay to resolve uncertainties is often not an option. Few scientists are trained to think this way — and certainly not climate scientists, who are having to improvise as the window of interventional opportunity shrinks.

Climate will, at times, force a hiatus on doing science as usual, much like what happened during World War II when many academics laid aside their usual teaching and research interests to intensively focus on the war effort.

The big working models of fluid dynamics used to simulate ocean and atmospheric circulation will themselves be game-changing for other fields of dynamics, such as brain processing and decision making. They should be especially important as they are incorporated into economic research. Climate problems will cause economies to stagger and we have just seen how fragile they are. Unlike 1997 when currency troubles were forced by a big El Niño and its associated fires in southeast Asia, the events of 2008 show that, even without the boat being rocked by external events, our economy can partially crash just from internal instabilities, equivalent to trying to dance in a canoe. Many people will first notice climate change elsewhere via the economic collapse that announces it.

That something as local as a U.S. housing bubble could trigger a worldwide recession shows us just how much work we have to do in "earthquake retrofits" for our economy. Climate-proofing our financial flows will rely heavily on good models of economic dynamics, studies of how things can go badly wrong within a month. With such models, we can test candidates for economic crash barriers.

Finally, climate's challenges will change our perspective on the future. Long-term thinking can be dangerous if it causes us to neglect the short term hazards. A mid-century plan for emissions reduction will be worthless if the Amazon rain forest burns down during the next El Niño.


CHRIS ANDERSON
Curator, TED Conference

A WEB-EMPOWERED REVOLUTION IN TEACHING

Today when we think of the world's teeming billions of humans, we tend to think: overpopulation, poverty, disease, instability, environmental destruction. They are the cause of most of the planet's problems.

What if that were to change? What if the average human were able to contribute more than consume? To add more than subtract? Think of the world as if each person drives a balance sheet. On the negative side are the resources they consume without replacing, on the positive side are the contributions they make to the planet in the form of the resources they produce, the lasting artifacts-of-value they build, and the ideas and technologies that might create a better future for their family, their community and for the planet as a whole. Our whole future hangs on whether the sum of those balance sheets can turn positive.

What might make that possible? One key reason for hope is that so far we have barely scraped the surface of human potential. Throughout history, the vast majority of humans have not been the people they could have been.

Take this simple thought experiment. Pick your favorite scientist, mathematician or cultural hero. Now imagine that instead of being born when and where they were, they had instead been born with the same in-built-but-unlocked abilities in a typical poverty-stricken village in, say, the France of 1200 or the Ethiopia of 1980. Would they have made the contribution they made? Of course not. They would never have received the education and encouragement it took to achieve what they did. Instead they would have simply lived out a life of poverty, with perhaps an occasional yearning that there must be a better way.

Conversely, an unknown but vast number of those grinding out a living today have the potential to be world-changers... if only we could find a way of unlocking that potential.

Two ingredients might be enough to do that. Knowledge and inspiration. If you learn of ideas that could transform your life, and you feel the inspiration necessary to act on that knowledge, there's a real chance your life will indeed be transformed.

There are many scary things about today's world. But one that is truly thrilling is that the means of spreading both knowledge and inspiration have never been greater. Five years ago, an amazing teacher or professor with the ability to truly catalyze the lives of his or her students could realistically hope to impact maybe 100 people each year. Today that same teacher can have their words spread on video to millions of eager students. There are already numerous examples of powerful talks that have spread virally to massive Internet audiences.

Driving this unexpected phenomenon is the fact that the physical cost of distributing a recorded talk or lecture anywhere in the world via the internet has fallen effectively to zero. This has happened with breathtaking speed and its implications are not yet widely understood. But it is surely capable of transforming global education.

For one thing, the realization that today's best teachers can become global celebrities is going to boost the caliber of those who teach. For the first time in many years it's possible to imagine ambitious, brilliant 18-year-olds putting 'teacher' at the top of their career choice list. Indeed the very definition of "great teacher" will expand, as numerous others outside the profession with the ability to communicate important ideas find a new incentive to make that talent available to the world. Additionally every existing teacher can greatly amplify their own abilities by inviting into their classroom, on video, the world's greatest scientists, visionaries and tutors. (Can a teacher inspire over video? Absolutely. We hear jaw-dropping stories of this every day.)

Now think about this from the pupils' perspective. In the past, everyone's success has depended on whether they were lucky enough to have a great mentor or teacher in their neighborhood. The vast majority have not been fortunate. But a young girl born in Africa today will probably have access in 10 years' time to a cell phone with a high-resolution screen, a web connection, and more power than the computer you own today. We can imagine her obtaining face-to-face insight and encouragement from her choice of the world's great teachers. She will get a chance to be what she can be. And she might just end up being the person who saves the planet for our grandchildren.


GREGORY PAUL
Independent Researcher; Author, Dinosaurs of the Air

THE FIRST MAJOR UPGRADE OF THE HUMAN BRAIN AND THE MIND IT GENERATES SINCE THE PLEISTOCENE

Predicting what has the potential to change everything — really change everything — in this century is not difficult. What I cannot know is whether I will live to see it, the data needed to reliably calculate the span of my mind's existence being insufficient.

According to the current norm I can expect to last another third of century. Perhaps more if I match my grandmother's life span — born in a Mormon frontier town the same year Butch Cassidy, the Sundance Kid and Etta Place sailed for Argentina, she happily celebrated her 100th birthday in 2001. But my existence may exceed the natural ceiling. Modern medicine has maximized life spans by merely inhibiting premature death. Sooner or later that will become passé as advancing technology renders death optional.

Evolution whether biological or technological has been speeding up over time as the ability to acquire, process and exploit information builds upon itself. Human minds adapted to comprehend arithmetic growth tend to underestimate exponential future progress. Born two years before the Wright's first flight, my young grandmother never imagined she would cross continents and oceans in near sonic flying machines. Even out of the box thinkers did not predict the hyperexpansion of computing power over the last half century. It looks like medicine is about to undergo a similar explosion. Extracellular matrix powder derived from pig bladders can regrow a chopped off finger with a brand new tip complete with nail. Why not regenerate entire human arms and legs, and organs?

DARPA funded researchers predict that we may soon be "replacing damaged and diseased body parts at will, perhaps indefinitely." Medical corporations foresee a gold mine in repairing and replacing defective organs using the cells from the victims' own body (avoiding the whole rejection problem). If assorted body parts ravaged by age can be reconstructed with tissues biologically as young and healthy as those of children, then those with the will and resources will reconstruct their entire bodies.

Even better is stopping and then reversing the very process of aging. Humans, like parrots, live exceptionally long lives because we are genetically endowed with unusually good cellular repair mechanisms for correcting the damage created by free radicals. Lured by the enormous market potential, drugs are being developed to tweak genes to further upgrade the human repair system. Other pharmaceuticals are expected to mimic the life extension that appears to stem from the body's protective reaction to suppressed caloric intake. It's quite possible, albeit not certain, that middle-aged humans will be able to utilize the above methods to extend their lives indefinitely. But keeping our obsolescing primate bodies and brains up and running for centuries and millennia will not be the Big Show.

The human brain and the mind it generates have not undergone a major upgrade since the Pleistocene. And they violate the basic safety rule of information processing — that it is necessary to back up the data. Something more sophisticated and redundant is required. With computing power doubling every year or two cheap personal computers should match the raw processing power of the human brain in a couple of decades, and then leave it in the dust.

If so, it should be possible to use alternative, technological means to produce conscious thought. Efforts are already underway to replace damaged brain parts such as the hippocampus with hypercomputer implants. If and when the initial medical imperative is met, elective implants will undoubtedly be used to upgrade normal brain operations. As the fast evolving devices improve they will begin to outperform the original brain, it will make less and less sense to continue to do one's thinking in the old biological clunker, and formerly human minds will become entirely artificial as they move into ultra sophisticated, dispersed robot systems.

Assuming that the above developments are practical, technological progress will not merely improve the human condition, it should replace it. The conceit that humans in anything like their present form will be able to compete in a world of immortal superminds with unlimited intellectual capacity is naïve; there simply will not be much for people to do. Do not for a minute imagine a society of crude Terminators, or Datas that crave to be as human as possible. Future robots will be devices of subtle sophistication and sensitivity that will expose humans as the big brained apes we truly are. The logic predicts that most humans will choose to become robotic.

Stopping the CyberRevolution is probably not possible, the growing knowledge base should make the production of superintelligent minds less difficult and much faster than is replicating, growing and educating human beings. Trying to ban the technology will work as well as the war on drugs. The replacement of humanity with a more advanced system will be yet another evolutionary event on the scale of the Cambrian revolution, the Permian and K/C extinctions that produced and killed off the nonavian dinosaurs, and the advent of humans and the industrial age.

The scenario herein is not radical or particularly speculative, it seems so only because it has not happened yet. If the robotic civilization comes to pass it will quickly become mundane to us. The ability of cognitive minds to adjust is endless.

Here's a pleasant secondary effect — supernaturalistic religion will evaporate as ordinary minds become as powerful as gods. What will the cybersociety be like? Hardly have a clue. How much of this will I live to see? I'll find out.


GEORGE DYSON
Science Historian; Author, Darwin Among the Machines

INTERSTELLAR VIRUSES

The detection of extraterrestrial life, extraterrestrial intelligence, or extraterrestrial technology (there’s a difference) will change everything. The game could be changed completely by an extraterrestrial presence discovered (or perhaps not discovered) here on earth.

SETI@home, our massively-distributed search for extraterrestrial communication, now links some five million terrestrial computers to a growing array of radio telescopes, delivering a collective 500 teraflops of fast Fourier transforms representing a cumulative two million years of individual processing time. Not a word (or even a picture) so far. However, as Marvin Minsky warned in 1970: "Instead of sending a picture of a cat, there is one area in which you can send the cat itself."

Life, assuming it exists elsewhere in the universe, will have had time to explore an unfathomable diversity of forms. Those best able to survive the passage of time, adapt to changing environments, and migrate unscathed across interstellar distances will become the most widespread. Life forms that assume digital representation, for all or part of their life cycle, will not only be able to send messages at the speed of light, they will be able to send themselves.

Digital organisms can be propagated economically even with extremely low probability of finding a host environment in which to germinate and grow. If the kernel is intercepted by a host that has discovered digital computing (whose ability to translate between sequence and structure, as Alan Turing and John von Neumann demonstrated, is as close to a universal common denominator as life and intelligence running on different platforms may be able to get) it has a chance. If we discovered such a kernel, we would immediately replicate it widely. Laboratories all over the planet would begin attempting to decode it, eventually compiling the coded sequence — intentionally or inadvertently — to utilize our local resources, the way a virus is allocated privileges within a host cell. The read-write privileges granted to digital organisms already include material technology, human minds, and, increasingly, biology itself. (What, exactly, are those screen savers doing at Dr. Venter’s laboratory during the night?)

According to Edward Teller, Enrico Fermi asked "Where is everybody?" at Los Alamos in 1950, when the subject of extraterrestrial beings came up over lunch. The answer to Fermi’s Paradox could be "We’ve arrived! Now help us unpack!" Fifty years later, over lunch at Stanford, I asked a 91-year-old Edward Teller (holding a wooden staff at his side like an Old Testament prophet) how Fermi’s question was holding up.

"Let me ask you," Teller interjected in his thick Hungarian accent. "Are you uninterested in extraterrestrial intelligence? Obviously not. If you are interested, what would you look for?"

"There's all sorts of things you can look for," I answered.  "But I think the thing not to look for is some intelligible signal... Any civilization that is doing useful communication, any efficient transmission of information will be encoded, so it won't be intelligible to us — it will look like noise."

"Where would you look for that?" asked Teller.

"I don't know..."

"I do!" 

"Where?"

"Globular clusters!" answered Teller.  "We cannot get in touch with anybody else because they choose to be so far away from us. In globular clusters, it is much easier for people at different places to get together.  And if there is interstellar communication at all, it must be in the globular clusters."

"That seems reasonable," I agreed. "My own personal theory is that extraterrestrial life could be here already... and how would we necessarily know? If there is life in the universe, the form of life that will prove to be most successful at propagating itself will be digital life; it will adopt a form that is independent of the local chemistry, and migrate from one place to another as an electromagnetic signal, as long as there's a digital world — a civilization that has discovered the Universal Turing Machine — for it to colonize when it gets there.  And that's why von Neumann and you other Martians got us to build all these computers, to create a home for this kind of life."

There was a long, drawn-out pause. "Look," Teller finally said, lowering his voice, "may I suggest that instead of explaining this, which would be hard... you write a science fiction book about it."

"Probably someone has," I said.

"Probably," answered Teller, "someone has not."

---

(the conversation with Edward Teller took place on 12 April 1999)

 


MICHAEL SHERMER
Publisher of Skeptic magazine, monthly columnist for Scientific American; Author, The Mind of the Market

ENERGY AND ECONOMICS: THE ROAD TO CIVILIZATION 1.0

It is January, named for the Roman God Janus (Latin for door), the doorway to the new year, and yet Janus-faced in looking to the past to forecast the future. This January, 2009, in particular, finds us at a crisis tipping point both economically and environmentally. If ever we needed to look to the past to save our future it is now. In particular, we need to do two things: (1) stop the implosion of the economy and enable markets to function once again both freely and fairly, and (2) make the transition from nonrenewable fossil fuels as the primary source of our energy to renewable energy sources that will allow us to flourish into the future. Failure to make these transformations will doom us to the endless tribal political machinations and economic conflicts that have plagued civilization for millennia. We need to make the transition to Civilization 1.0. Let me explain.

In a 1964 article on searching for extraterrestrial civilizations, the Soviet astronomer Nikolai Kardashev suggested using radio telescopes to detect energy signals from other solar systems in which there might be civilizations of three levels of advancement: Type 1 can harness all of the energy of its home planet; Type 2 can harvest all of the power of its sun; and Type 3 can master the energy from its entire galaxy.

Based on our energy efficiency at the time, in 1973 the astronomer Carl Sagan estimated that Earth represented a Type 0.7 civilization on a Type 0 to Type 1 scale. (More current assessments put us at 0.72.) As the Kardashevian scale is logarithmic — where any increase in power consumption requires a huge leap in power production — fossil fuels won’t get us there. Renewable sources such as solar, wind and geothermal are a good start, and coupled to nuclear power — perhaps even nuclear fusion (instead of the fission reactors we have now) could eventually get us to Civilization 1.0.

We are close. Taking our Janus-faced look to the past in order to see the future, let’s quickly review the history of humanity on its climb to become a Civilization 1.0:

Type 0.1: Fluid groups of hominids living in Africa. Technology consists of primitive stone tools. Intra-group conflicts are resolved through dominance hierarchy, and between-group violence is common.

Type 0.2: Bands of roaming hunter-gatherers that form kinship groups, with a mostly horizontal political system and egalitarian economy.

Type 0.3: Tribes of individuals linked through kinship but with a more settled and agrarian lifestyle. The beginnings of a political hierarchy and a primitive economic division of labor.

Type 0.4: Chiefdoms consisting of a coalition of tribes into a single hierarchical political unit with a dominant leader at the top, and with the beginnings of significant economic inequalities and a division of labor in which lower-class members produce food and other products consumed by non-producing upper-class members.

Type 0.5: The state as a political coalition with jurisdiction over a well-defined geographical territory and its corresponding inhabitants, with a mercantile economy that seeks a favorable balance of trade in a win-lose game against other states.

Type 0.6: Empires extend their control over peoples who are not culturally, ethnically or geographically within their normal jurisdiction, with a goal of economic dominance over rival empires.

Type 0.7: Democracies that divide power over several institutions, which are run by elected officials voted for by some citizens. The beginnings of a market economy.

Type 0.8: Liberal democracies that give the vote to all citizens. Markets that begin to embrace a nonzero, win-win economic game through free trade with other states.

Type 0.9: Democratic capitalism, the blending of liberal democracy and free markets, now spreading across the globe through democratic movements in developing nations and broad trading blocs such as the European Union.

Type 1.0: Globalism that includes worldwide wireless Internet access with all knowledge digitized and available to everyone. A global economy with free markets in which anyone can trade with anyone else without interference from states or governments. A planet where all states are democracies in which everyone has the franchise.

Looking from this past toward the future, we can see that the forces at work that could prevent us from reaching Civilization 1.0 are primarily political and economic, not technological. The resistance by non democratic states to turning power over to the people is considerable, especially in theocracies whose leaders would prefer we all revert to Type 0.4 chiefdoms. The opposition toward a global economy is substantial, even in the industrialized West, where economic tribalism still dominates the thinking of most people.

The game-changing scientific idea is the combination of energy and economics — the development of renewable energy sources made cheap and available to everyone everywhere on the planet by allowing anyone to trade in these game-changing technologies with anyone else. That will change everything.


DANIEL L. EVERETT
Chair of Languages, Literatures, & Cultures, Professor of Linguistics and Anthropology, Illinois State University; Author, Don't Sleep, There Are Snakes

UNDOING BABYLON

"We should really not be studying sentences; we should not be studying language — we should be studying people" Victor Yngve

Communication is the key to cooperation. Although cross-cultural communication for the masses requires translation techniques that exceed our current capabilities, the groundwork of this technology has already been laid and many of us will live to see a revolution in automatic translation that will change everything about cooperation and communication across the world.

This goal was conceived in the late 1940s in a famous memorandum by Rockefeller Foundation scientist, Warren Weaver, in which he suggested the possibility of machine translation and tied its likelihood to four proposals, still controversial today: that there was a common logic to languages; that there were likely to be language universals; that immediate context could be understood and linked to translation of individual sentences; and that cryptographic methods developed in World War II would apply to language translation. Weaver's proposals got off the ground financially in the early 1950s as the US military invested heavily in linguistics and machine translation across the US, with particular emphasis on the research of the team of Victor Yngve at the Massachusetts Institute of Technology's Research Laboratory of Electronics (a team that included the young Noam Chomsky).

Yngve, like Weaver, wanted to contribute to international understanding by applying the methods of the then incipient field that he helped found, computational linguistics, to communication, especially machine translation. Early innovators in this area also included Claude Shannon at Bell Labs and Yehoshua Bar-Hillel who preceded Yngve at MIT before returning to Israel. Shannon was arguably the inventor of the concept of information as an entity that could be scientifically studied and Bar-Hillel was the first person to work full-time on machine translation, beginning the program that Yngve inherited at MIT.

This project was challenged early on, however, by the work of Chomsky, from within Yngve's own lab. Chomsky's conclusions about different grammar types and their relative generative power convinced people that grammars of natural languages were not amenable to machine translation efforts as they were practiced at the time, leading to a slowdown in and reduction of enthusiasm for computationally-based translation.

As we have subsequently learned, however, the principal problem faced in machine-translation is not the formalization of grammar per se, but the inability of any formalization known, including Chomsky's, to integrate context and culture (semantics and pragmatics in particular) into a model of language appropriate for translation. Without this integration, mechanical translation from one language to another is not possible.

Still, mechanical procedures able to translate most contents from any source language into accurate, idiomatically natural constructions of any target language seem less utopian to us now because of major breakthroughs that have led to several programs in machine translation (e.g. the Language Technologies Institute at Carnegie Mellon University). I believe that we will see within our lifetime the convergence of developments in artificial intelligence, knowledge representation, statistical grammar theories, and an emerging field — computational anthropology (informatic-based analysis and modeling of cultural values) — that will facilitate powerful new forms of machine translation to match the dreams of early pioneers of computation.

The conceptual breakthroughs necessary for universal machine translation will also require contributions from Construction Grammars, which view language as a set of conventional signs (varieties of the idea that the building blocks of grammar are not rules or formal constraints, but conventional phrase and word forms that combine cultural values and grammatical principles), rather than a list of formal properties. They will have to look at differences in the encoding of language and culture across communities, rather than trying to find a 'universal grammar' that unites all languages.

At least some of the steps are easy enough to imagine. First, we come up with a standard format for writing statistically-based Construction Grammars of any language, a format that displays the connections between constructions, culture, and local context (such as the other likely words in the sentence or other likely sentences in the paragraph in which the construction appears). This format might be as simple as a flowchart or a list. Second, we develop a method for encoding context and values. For example, what are the values associated with words; what are the values associated with certain idioms; what are the values associated with the ways in which ideas are expressed? The latter can be seen in the notion of sentence complexity, for example, as in the Pirahã of the Amazon's (among others) rejection of recursive structures in syntax because they violate principles of information rate and new vs. old information in utterances that are very important in Pirahã culture. Third, we establish lists of cultural values and most common contexts and how these link to individual constructions. Automating the procedure for discovering or enumerating these links will take us to the threshold of automatic translation in the original sense.

Information and its exchange form the soul of human cultures. So just imagine the possible change in our perceptions of 'others' when we able to type in a story and have it automatically and idiomatically translated with 100% accuracy into any language for which we have a grammar of constructions. Imagine speaking into a microphone and having your words come out in the language of your audience, heard and understood naturally. Imagine anyone being able to take a course in any language from any university in the world over the internet or in person, without having to first learn the language of the instructor.

These will always be unreachable goals to some degree. It seems unlikely, for example, that all grammars and cultures are even capable of expressing everything from all languages. However, we are developing tools that will dramatically narrow the gaps and help us decide where and how we can communicate particular ideas cross-culturally. Success at machine translation might not end all the world's sociocultural or political tensions, but it won't hurt. One struggles to think of a greater contribution to world cooperation than progress to universal communication, enabling all and sundry to communicate with nearly all and sundry. Babel means 'the gate of god'. In the Bible it is about the origin of world competition and suspicion. As humans approached the entrance to divine power by means of their universal cooperation via universal communication, so the biblical story goes, language diversity was introduced to destroy our unity and deprive us of our full potential.

But automated, near-universal translation is coming. And it will change everything.



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THOMAS METZINGER
Philosopher, Wissenschaftskolleg zu Berlin (Institute for Advanced Study); Author, The Ego Tunnel

SOUL-TRAVEL FOR SELFLESS BEINGS

John Brockman points out that new technology leads not only to new ways of perceiving ourselves, but also to a process he calls "recreating ourselves." Could this become true in an even deeper and more radical way than through gene-technology? The answer is yes.

It is entirely plausible that we may one day directly control virtual models of our own bodies directly with our brain. In 2007, I first experienced taking control of a computer-generated whole-body model myself. It took place in a virtual reality lab where my own physical motions were filmed by 18 cameras picking up signals from sensors attached to my body. Over the past two years, different research groups in Switzerland, England, Germany and Sweden have demonstrated how, in a passive condition, subjects can consciously identify with the content of a computer-generated virtual body representation, fully re-locating the phenomenal sense of self into an artificial, visual model of their body.

In 2008, in another experiment, we saw that a monkey on a treadmill could control the real-time walking patterns a humanoid robot via a brain-machine interface directly implanted into its brain. The synchronized robot was in Japan, while the poor monkey was located thousands of miles away, in the US. Even after it stopped walking, the monkey was able to sustain locomotion of the synchronized robot for a few minutes — just by using the visual feedback transmitted from Japan plus his own "thoughts" (whatever that may turn out to be).

Now imagine two further steps.

First, we manage to selectively block the high-bandwidth "interoceptive" input into the human self-model — all the gut feelings and the incessant flow of inner body perceptions that anchor the conscious self in the physical body. After all, we already have selective motor control for an artificial body-model and robust phenomenal self-identification via touch and sight. By blocking the internal self-perception of the body, we could be able to suspend the persistent causal link to the physical body.

Second, we develop richer and more complex avatars, virtual agents emulating not only the proprioceptive feedback generated by situated movement, but also certain abstract aspects of ongoing global control itself — new tools, as Brockman would call them. Then suddenly it happens that the functional core process initiating the complex control loop connecting physical and virtual body jumps from the biological brain into the avatar.

I don't believe this will happen tomorrow. I also don't believe that it would change everything. But it would change a lot.


JESSE BERING
Psychologist, Director, Institute of Cognition and Culture, Queens University, Belfast

GOD NEEDN'T ACTUALLY EXIST TO HAVE EVOLVED

What if I were to tell you that God were all in your mind? That God, like a tiny spec floating at the edge of your cornea producing the image of a hazy, out-of-reach orb accompanying your every turn, were in fact an illusion, a psychological blemish etched onto the core cognitive substrate of your brain? It may feel like there is something grander out there…. watching, knowing, caring. Perhaps even judging. But in fact there is only the air you breathe. Consider, briefly, the implications of seeing God this way, as a sort of scratch on our psychological lenses rather than the enigmatic figure out there in the heavenly world most people believe him to be. Subjectively, God would still be present in our lives. In fact rather annoyingly so. As a way of perceiving, he would continue to suffuse our experiences with an elusive meaning and give the sense that the universe is communicating with us in various ways. But objectively, the notion of God as an illusion is a radical and some would say even dangerous idea, since it raises important questions about God as an autonomous, independent agent that lives outside human brain cells.

In fact, the illusion of God is more plausible a notion than some other related thought experiments, such as the possibility that our brains are sitting in an electrified vat somewhere and we're merely living out simulated lives. In contrast to the vat exercise or some other analogy to the science-fiction movie The Matrix, it is rather uncontroversial to say that our species' ability to think about God — even an absent God — is made possible only by our very naturally derived brains. In particular, by virtue of the fact that our brains have evolved over the eons in the unusual manner they have. In philosophical discourse, the idea that God is an illusion would be a scientifically inspired twist on a very ancient debate, since it deals with the nature and veridicality of God's actual being.

That's all very well, you may be thinking. But perhaps God isn't an illusion at all. Rather than a scratch on our psychological lenses, our brain's ability to reason about the supernatural — about such things as purpose, the afterlife, destiny — is in fact God's personal signature on our brains. One can never rule out the possibility that God micro-engineered the evolution of the human brain so that we've come to see him more clearly, a sort of divine Lasik procedure, or a scraping off the bestial glare that clouds the minds of other animals. In fact some scholars, such as psychologists Justin Barrett and Michael Murray, hold something like this "theistic evolution" view in their writings. Yet as a psychological scientist who studies religion, I take explanatory parsimony seriously. After all, parsimony is the basic premise of Occam's Razor, the very cornerstone of all scientific enquiry. Occam's Razor holds that, of two equally plausible theories, science shaves off the extra fat by favoring the one that makes the fewest unnecessary assumptions. And in the natural sciences, the concept of God as a causal force tends to be an unpalatable lump of gristle. Although treating God as an illusion may not be entirely philosophically warranted, therefore, it is in fact a scientifically valid treatment. Because the human brain, like any physical organ, is a product of evolution, and since natural selection works without recourse to intelligent forethought, this mental apparatus of ours evolved to think about God quite without need of the latter's consultation, let alone his being real.

Indeed, the human brain has many such odd quips that systematically alter, obscure, or misrepresent entirely the world outside our heads. That's not a bad thing necessarily; nor does it imply poor adaptive design. You have undoubtedly seen your share of optical illusions before, such as the famous Müller-Lyer image where a set of arrows of equal length with their tails in opposite directions creates the subjective impression that one line is actually longer than the other. You know, factually, the lines are of equal length, yet despite this knowledge your mind does not allow you to perceive the image this way. There are also well-documented social cognitive illusions that you may not be so familiar with. For example, David Bjorklund, a developmental psychologist, reasons that young children's overconfidence in their own abilities keeps them engaging in challenging tasks rather than simply giving up when they fail. Ultimately, with practice and over time, children's actual skills can ironically begin to more closely approximate these earlier, favorably warped self-judgments. Similarly, evolutionary psychologists David Buss and Martie Haselton argue that men's tendency to over-interpret women's smiles as sexual overtures prompts them to pursue courtship tactics more often, sometimes leading to real reproductive opportunities with friendly women.

In other words, from both a well-being and a biological perspective, whether our beliefs about the world 'out there' are true and accurate matters little. Rather, psychologically speaking, it's whether they work for us — or for our genes — that counts. As you read this, cognitive scientists are inching their way towards a more complete understanding of the human mind as a reality-bending prism. What will change everything? The looming consensus among those who take Occam's Razor seriously that the existence of God is a question for psychologists and not physicists.


RICHARD FOREMAN
Founder Director, Ontological-Hysteric Theater; Playwright

NOTHING WILL CHANGE EVERYTHING

The belief that there is anything that will change things, in and of itself stymies, I believe, real change. To believe that anything "will change things" focuses one on the superficial surface of things, which indeed change all the time. Such changes — which have been and will continue to be — create always an orientation of consciousness that focuses always on "the future".

But I propose that the only thing that will in fact 'change everything' is, or would be, the refusal to think about the future. And this, of course, is almost impossible for almost all human beings to do.

Therefore, nothing will change everything.

(I admit that I myself have fallen prey to this unavoidable human tendency, having written "of the future" in these pages, proposing that the internet is now creating, and will radicalized in the future — wide ranging yet depthless "pancake people".)

But if we could "think not" about the future, the present moment would obviously expand and become the full (and very different) universe. One can say "ah, but this is the animal state".

I would answer — no, the animal achieves this automatically, while the human being who achieves this only does so by erecting it on a foundational superstructure which postulates a necessary 'future' (past-based) much as Freud (and others before him) postulated a necessary "unconscious' — out of which the 'conscious' human being emerged.

(I am aware, obviously, that this theme has been engaged by philosophers and mystics down through the ages).

So for a human being to not think about the future would be to become a non-animal inhabiting the pure present (the dream of so called 'avant-guard' art, by the way). And animals do not (apparently) make avant-guard art.

Take John Brockman's offered example of a future event that changes everything — through genetic manipulation "your dog could become your cat" (and by implication, I could become you, etc.)

I say, this changes only the shell. Such alterations and achievements, along with many others similarly imaginable, add but another room onto the "home" inhabited by human beings — who will still spend most of their time "thinking about the future. And nothing, at the deepest level, therefore will ever change a postulated 'everything' — not so long as we keep imagining possible "change" which only reinforces the psychic dwelling of our un-changing selves in a "future" that is always imaginary and beyond us.


CLIFFORD A. PICKOVER
Science Writer, Author, Archimedes to Hawking

PROOF OF THE RIEMANN HYPOTHESIS

Many mathematical surveys indicate that the "Proof of the Riemann Hypothesis" is the most important open question in mathematics. The rapid pace of mathematics, along with computer-assisted mathematical proofs and visualizations, leads me to believe that this question will be resolved in my lifetime. Math aficionado John Fry once said that he thought we would have a better chance of finding life on Mars than finding a counterexample for the Riemann Hypothesis.

In the early 1900s, British mathematician Godfrey Harold Hardy sometimes took out a quirky form of life insurance when embarking on ocean voyages. In particular, he would mail a postcard to a colleague on which he would claim to have found the solution of the Riemann Hypothesis. Hardy was never on good terms with God and felt that God would not let him die in a sinking ship while Hardy was in such a revered state, with the world always wondering if he had really solved the famous problem.

The proof of the Riemann Hypothesis involves the zeta function, which can be represented by a complicated-looking curve that is useful in number theory for investigating properties of prime numbers. Written as f(x), the function was originally defined as the infinite sum:

equation

When x = 1, this series has no finite sum. For values of x larger than 1, the series adds up to a finite number. If x is less than 1, the sum is again infinite. The complete zeta function, studied and discussed in the literature, is a more complicated function that is equivalent to this series for values of x greater than 1, but it has finite values for any real or complex number, except for when the real part is equal to one. We know that the function equals zero when x is -2, -4, -6, ... . We also know that the function has an infinite number of zero values for the set of complex numbers, the real part of which is between zero and one — but we do not know exactly for what complex numbers these zeros occur. In 1859, mathematician Georg Bernhard Riemann (1826–1866) conjectured that these zeros occur for those complex numbers the real part of which equals 1/2. Although vast numerical evidence exists that favors this conjecture, it is still unproven

The proof of Riemann's Hypothesis will have profound consequences for the theory of prime numbers and in our understanding of the properties of complex numbers. A generalized version of the Hypothesis, when proven true, will allow mathematicians to solve numerous important mathematical problems. Amazingly, physicists may have found a mysterious connection between quantum physics and number theory through investigations of the Riemann Hypothesis. I do not know if God is a mathematician, but mathematics is the loom upon which God weaves the fabric of the universe.

Today, over 11,000 volunteers around the world are working on the Riemann Hypothesis, using a distributed computer software package at Zetagrid.Net to search for the zeros of the Riemann zeta function. More than 1 billion zeros for the zeta function are calculated every day.

In modern times, mathematics has permeated every field of scientific endeavor and plays an invaluable role in biology, physics, chemistry, economics, sociology, and engineering. Mathematics can be used to help explain the colors of a sunset or the architecture of our brains. Mathematics helps us build supersonic aircraft and roller coasters, simulate the flow of Earth's natural resources, explore subatomic quantum realities, and image faraway galaxies. Mathematics has changed the way we look at the cosmos.

Physicist Paul Dirac once noted that the abstract mathematics we study now gives us a glimpse of physics in the future. In fact, his equations predicted the existence of antimatter, which was subsequently discovered. Similarly, mathematician Nikolai Lobachevsky said that "there is no branch of mathematics, however abstract, which may not someday be applied to the phenomena of the real world."


NICHOLAS HUMPHREY
Psychologist, London School of Economics; Author, Seeing Red

WHY HUMAN NATURE WILL REBEL

We're easily seduced by the idea that, once the Big One comes, nothing will ever be the same again. But I guess what will surprise — and no doubt frustrate — those who dream of a scientifically-driven new order is how unchangeable, and unmanageable by technology, human lives are.

Imagine if this Edge question had been posed to the citizens of Rome two thousand years ago. Would they have been able to predict the coming of the internet, DNA finger-printing, mind-control, space travel? Of course not. Would that mean they would have failed to spot the technological developments that were destined to change everything? I don't think so. For the fact is nothing has changed everything.

Those Romans, despite their technological privations, led lives remarkably like ours. Bring them into the 21st century and they would of course be amazed by what science has achieved. Yet they would soon discover that beneath the modern wrapping it is business as usual. Politics, crime, love, religion, heroism.. The stuff of human biography. The more it changes, the more it's the same thing.

The one development that really could change everything would be a radical, genetically programmed, alteration of human nature. It hasn't happened in historical times, and I'd bet it won't be happening in the near future either. Cultural and technical innovations can certainly alter the trajectory of individual human lives. But, while human beings continue to reproduce by having sex and each new generation goes back to square one, then every baby begins life with a set of inherited dispositions and instincts that evolved in the technological dark ages.

The Latin poet Horace wrote: "You can drive out nature with a pitchfork, but she will always return". Let's dream, if we like, of revolution. But be prepared for more of the same.


FREEMAN DYSON
Physicist, Institute of Advanced Studies; Author, The Scientist as Rebel

"RADIOTELEPATHY", THE DIRECT COMMUNICATION OF FEELINGS AND THOUGHT FROM BRAIN TO BRAIN

What will change everything?  What game-changing scientific ideas and developments do you expect to live to see?

Since I am 85, I cannot expect to see any big changes in science during my life-time. I beg permission to change the question to make it more interesting.

What will change everything?  What game-changing scientific ideas and developments do you expect your grandchildren to see?

I assume that some of my grandchildren will be alive for the next 80 years, long enough for neurology to become the dominant game-changing science. I expect that genetics and molecular biology will be dominant for the next fifty years, and after that neurology will have its turn. Neurology will change the game of human life drastically, as soon as we develop the tools to observe and direct the activities of a human brain in detail from the outside.

The essential facts which will make detailed observation or control of a brain possible are the following. Microwave signals travel easily through brain tissue for a few centimeters. The attenuation is small enough, so that signals can be transmitted from the inside and detected on the outside. Small microwave transmitters and receivers have bandwidths of the order of gigahertz, while neurons have bandwidths of the order of kilohertz. A single microwave transmitter inside a brain has enough bandwidth to transmit to the outside the activity of a million neurons. A system of 10^5 tiny transmitters inside a brain with 10^5 receivers outside could observe in detail the activity of an entire human brain with 10^11 neurons. A system of 10^5 transmitters outside with 10^5 receivers inside could control in detail the activity of 10^11 neurons. The microwave signals could be encoded so that each of the 10^11 neurons would be identified by the code of the signal that it transmits or receives.

These physical tools would make possible the practice of "Radiotelepathy", the direct communication of feelings and thoughts from brain to brain. The ancient myth of telepathy, induced by occult and spooky action-at-a-distance, would be replaced by a prosaic kind of telepathy induced by physical tools. To make radiotelepathy possible, we have only to invent two new technologies, first the direct conversion of neural signals into radio signals and vice versa, and second the placement of microscopic radio transmitters and receivers within the tissue of a living brain. I do not have any idea of the way these inventions will be achieved, but I expect them to emerge from the rapid progress of neurology before the twenty-first century is over.

It is easy to imagine radiotelepathy as a powerful instrument of social change, used either for good or for evil purposes. It could be a basis for mutual understanding and peaceful cooperation of humans all over the planet. Or it could be a basis for tyrannical oppression and enforced hatred between one communal society and another. All that we can say for certain is that the opportunities for human experience and understanding would be radically enlarged. A society bonded together by radiotelepathy would be experiencing human life in a totally new way. It will be our grandchildren's task to work out the rules of the game, so that the effects of radiotelepathy remain constructive rather than destructive. It is not too soon for them to begin thinking about the responsibilities that they will inherit. The first rule of the game, which should not be too difficult to translate into law, is that every individual should be guaranteed the ability to switch off radio communication at any time, with or without cause. When the technology of communication becomes more and more intrusive, privacy must be preserved as a basic human right.

Another set of opportunities and responsibilities will arise when radiotelepathy is extended from humans to other animal species. We will then experience directly the joy of a bird flying or a wolf-pack hunting, the pain of a deer hunted or an elephant starved. We will feel in our own flesh the community of life to which we belong.  I cannot help hoping that the sharing of our brains with our fellow-creatures will make us better stewards of our planet.


IAN MCEWAN
Novelist; Author, On Chesil Beach

THE FULL FLOURISHING OF SOLAR TECHNOLOGY

Philip Larkin began a poem with the hypothesis, If I were called in/ To construct a religion/ I should make use of water. Instead of water, I would propose the sun, and the religion I have in mind is a rational affair, with enormous aesthetic possibilities and of great utility.

By nearly all insider and expert accounts, we are or will be at peak oil somewhere between now and the next five years. Even if we did not have profound concerns about climate change, we would need to be looking for different ways to power our civilization. How fortunate we are to have a safe nuclear facility a mere 93 million miles away, and fortunate too that the dispensation of physical laws is such that when a photon strikes a semi-conductor, an electron is released. I hope I live to see the full flourishing of solar technology — photovoltaics or concentrated solar power to superheat steam, or a combination of the two in concentrated photovoltaics. The technologies are unrolling at an exhilarating pace, with input from nanotechnology and artificial photosynthesis. Electric mobility and electricity storage are also part of this new quest. My hope is that architects will be drawn to designing gorgeous arrays and solar towers in the desert — as expressive of our aspirations as Medieval cathedrals once were. We will need new distribution systems too, smart grids — perfect Rooseveltian projects for our hard-pressed times. Could it be possible that in two or three decades we will look back and wonder why we ever thought we had a problem when we are bathed in such beneficent radiant energy?


IRENE PEPPERBERG
Psychologist, Research Associate, Harvard University; Author, Alex and Me

THINKING SMALL: UNDERSTANDING THE BRAIN

Knowledge of exactly how the brain works will change everything. Despite all our technical advances in brain-mapping, we still do not fully understand how the human or nonhuman brain works as a complete organ — e.g., the interconnectedness of the separate areas we are currently mapping. Just as we are beginning to learn that it is not "the" gene that controls what happens in our bodies, but rather the interplay of many genes, proteins, and environmental influences that turn genes on and off, we will learn how the interplay of various neural tissues, the chemicals in our body, environmental influences, and possibly some current unknowns, come together to affect how the brain works…and that will change everything.

We will, for example:

(a) ameliorate diseases in which the brain stops working properly — from diseases involving cognitive deficits such as Alzheimers to those involving issues of physical control such as Parkinsons. We will monitor just when the brain stops functioning optimally and begin interventions much earlier. Age-related senility, with its concomitant problems and societal costs, will cease to exist. If dysfunctions such as autism and schizophrenia are indeed the result of faulty interconnections among many disparate areas, we will 'rewire' the appropriate systems either physically or through targeted drug intervention….similarly for problems such as dyslexia and ADHD;

(b) understand and repair brains susceptible to addictions, or criminality that is based on lack of inhibitory control;

(b) use this knowledge to develop models of brain function for advanced robotics and computers to design 'smart' interactive systems for, e.g., space and ocean exploration or seamless interfaces for, e.g., artificial limbs, vision, and hearing;

(c) determine ways in which human and nonhuman brains function similarly and differently, whether human and nonhuman intelligences are distinctly separate or whether a measureable gradient exists, the extent of any overlap of function, and whether the critical issues involve modules or a constellation of inter-functioning areas that both match and are disparate. For example, we will better understand how human intelligence and language evolved and the extent to which parallel intelligence and communication evolved in nonmammalian evolutionary lines. And how they may still be evolving….

(d) maybe frighteningly, attempt to improve upon the current human brain in an anatomical sense, or, in a much more acceptable manner, determine what forms of teaching and training enable learning to proceed most rapidly, by enhancing appropriate connectivity and memory formation. Different types of intelligence will likely be found to be correlated with particular brain organizational patterns; thus we will identify geniuses of particular sorts more readily and cultivate their abilities.

By truly understanding brain function, and harnessing it most effectively, we will affect everything else in the universe — for better or worse.


HAIM HARARI
Physicist, former President, Weizmann Institute of Science; Author, A View from the Eye of the Storm

AT LAST: TECHNOLOGY WILL CHANGE EDUCATION

Sometimes you make predictions. Sometimes you have wishful thinking. It is a pleasure to indulge in both, by discussing one and the same development which will change the world.

Today's world, its economy, industry, environment, agriculture, energy, health, food, military power, communications, you name it, are all driven by knowledge. The only way to fight poverty, hunger, diseases, natural catastrophes, terrorism, war, and all other evil, is the creation and dissemination of knowledge, i.e. research and education.

Of the six billion people on our planet, at least four billions are not participating in the knowledge revolution. Hundreds of millions are born to illiterate mothers, never drink clean water, have no medical care and never use a phone.

The "buzz words" of distant learning, individualized learning, and all other technology-driven changes in education, remain largely on paper, far from becoming a daily reality in the majority of the world's schools. The hope that affluent areas will provide remote access good education to others has not materialized. The ideas of bringing all of science, art, music and culture to every corner of the world and the creation of schools designed differently, based on individual and group learning, team work, simulations and special aids to special needs — all of these technology enabled goals remain largely unfulfilled.

It is amazing that, after decades of predictions and projections, education, all around the world, has changed so little. Thirty years ago, pundits talked about the thoroughly computerized school. Many had fantasies regarding an entirely different structure of learning, remote from the standard traditional school-class-teacher complex, which has hardly changed in the last century.

It is even more remarkable that no one has made real significant money on applying the information revolution to education. With a captive consumer audience of all school children and teachers in the world, one would think that the money made by eBay, Amazon, Google and Facebook might be dwarfed by the profits of a very clever revolutionary idea regarding education. Yet, no education oriented company is found among the ranks of the web-billionaires.

How come the richest person on the globe is not someone who had a brilliant idea about using technology for bringing education to the billions of school children of the world? I do not know the complete answer to this question. A possible guess is that in other fields you can have "quickies" but not in education. The time scale of education is decades, not quarters. Another possible guess is that, in education, you must mix the energy and creativity of the young with the wisdom and experience of the older, while in other areas, the young can do it fast and without the baggage of the earlier generations.

I am not necessarily bemoaning the fact that no one got into the list of richest people in the world by reforming education. But I do regret that no "game-changing" event has taken place on this front, by exploiting what modern technology is offering.

Four million Singapore citizens have a larger absolute GDP than 130 million Pakistanis. This is not unrelated to all the miseries and problems of Pakistan, from poverty to terror to severe earthquake damage. The only way to change this, in the long run, is education. Nothing better can happen to the world, than better education to such a country. But, relying only on local efforts may take centuries. On the other hand, if Al Qaida can reach other continents from Pakistan by using the web, why can't the world help educate 130 million Pakistanis using better methods?

So, my game-changing hope and prediction is that, finally, something significant will change on this front. The time is ripe. A few novel ideas, aided by technologies that did not exist until recently, and based on humanistic values, on compassion and on true desire to extend help to the uneducated majority of the earth population, can do the trick.

Am I naive, stupid or both? Why do I think that this miracle, predicted for 30 years by many, and impatiently waited for by more, will finally happen in the coming decades?

Here are my clues:

First, a technology-driven globalization is forcing us to see, to recognize and to fear the enormous knowledge gaps between different parts of the world and between segments of society within our countries. It is a major threat to everything that the world has achieved in the last 100 years, including democracy itself. Identifying the problem is an important part of the solution.

Second, the speed and price of data transmission, the advances in software systems, the feasibility of remote video interactions, the price reduction of computers, fancy screens and other gadgets, finally begin to lead to the realization that special tailor-made devices for schools and education are worth designing and producing. Until now, most school computers were business computers used at school and very few special tools were developed exclusively for education. This is beginning to change.

Third, for the first time, the generation that grew up with a computer at home is reaching the teacher ranks. The main obstacle of most education reforms has always been the training of the teachers. This should be much easier now. Just remember the first generation of Americans who grew up in a car-owning family. It makes a significant difference.

Fourth, the web-based social networks in which the children now participate pose a new challenge. The educational system must join them, because it cannot fight them. So the question is not any more: "Will there be a revolution in education?" But "Will the revolution be positive or deadly?" Too many revolutions in history have led to more pain and death than to progress. We must get this one right.

Fifth, a child who comes to school with a 3G phone, iPod or whatever, sending messages to his mother's blackberry and knowing in real time what is happening in the class room of his brother or friend miles or continents away, cannot be taught anything in the same way that I was taught. Has anyone seen lately a slide rule? A logarithmic table? A volume of Pedia other than Wiki?

At this point I could produce long lists of specific ideas which one may try or of small steps which have already been taken, somewhere in the world. But that is a matter for long essays or for a book, not for a short comment. It is unlikely that one or three or ten such ideas will do the job. It will have to be an evolutionary process of many innovations, trial and error, self adjustment, avoiding repetition of past mistakes and, above all, patience. It will also have to include one or more big game-changing elements of the order of magnitude of the influence of Google.

This is a change that will create a livable world for the next generations, both in affluent societies and, especially, in the developing or not-even-yet-developing parts of the world. Its time has definitely come. It will happen and it will, indeed, change everything.


PAUL J. STEINHARDT
Physicist; Albert Einstein Professor of Science, Princeton University; Coauthor, Endless Universe

BLACK HOLES: THE ULTIMATE GAME-CHANGER?

One of the sacred principles of physics is that information is never lost. It can be scrambled, encrypted, dissipated and shredded, but never lost. This tenet underlies the second law of thermodynamics and a concept called "unitarity," an essential component of unified theories of particles and forces. Discovering a counterexample or new ways to preserve information could be a real game-changer: one that alters our understanding of the fundamental laws of nature, transforms our concept of space and time, triggers a reconstruction of the history of the universe and leads to new prognostications about its future.

There is a real chance of breakthrough in the foreseeable future as theorists converge on one of the greatest threats to information preservation: black holes. According to Einstein's general theory of relativity, a black hole forms when matter is so concentrated that nothing, not even light, can escape its gravitational field. Any information that passes through the event horizon surrounding the black hole—the "point of no return"—is lost forever to the outside world. Suppose, for example, that Bob pilots a spaceship into the black hole carrying along three books of his choice. It appears that the titles and contents of the three books vanish. Either that or Einstein's general theory of relativity is wrong.

There is nothing shocking about having to correct Einstein's general theory of relativity. It's known to be missing an essential element, quantum physics. Einstein, and generations of theorists since, have sought an improved theory of gravity that incorporates quantum physics in a way that is mathematically and physically consistent. String theory and loop quantum gravity are the most recent attempts.

There is no doubt that quantum physics alters the event horizon and the evolution of a black hole in a fundamental way, as first point out in the work of Jacob Bekenstein, Gary Gibbons and Stephen Hawking in the 1970s. According to quantum physics, matter and energy are composed of discrete chunks known as quanta (such as electrons, quarks and photons) whose position and velocities are undergoing constant random fluctuations. Even empty space—a pure vacuum—is seething with microscopic fluctuations that create and annihilate pairs of quanta and anti-quanta. The seething vacuum just outside the event horizon occasionally produces a pair of quanta, such as an electron-positron duo, in which one escapes and one falls into the black hole. From afar, it appears that the black hole radiates a particle. This phenomenon repeats continuously, producing a spectrum of particles known as "Hawking radiation," whose properties are similar to the "thermal radiation" emitted by a hot body. Very slowly, the black hole radiates away energy and shrinks in mass and size until—well, here is where the story really begins to get interesting.

Thermal radiation only depends on the temperature of the emitting body, providing no other details about the body itself. So, if Hawking radiation is truly thermal, then the information inside the black hole is truly lost . For the last decade, though, leading physicists including Gerard 't Hooft, Leonard Susskind, and Stephen Hawking fiercely debated (and even bet on) the outcome—Susskind refers to the debate as the "black hole war." Aided by new theoretical tools developed by Juan Maldacena and other string theorists, physicists discovered that Hawking radiation is not quite thermal after all! The radiation deviates by a tiny amount from a perfectly thermal signal, and the tiny deviation incorporates information about whatever was inside. The titles of Bob's three books, for example, are not lost forever, although the information dribbles out incredibly slowly and is unimaginably scrambled. Thus, victory was declared in the black hole war.

But it may be an uneasy peace, for there remains the question of what happens to information after it falls into the horizon. This is a reasonable question because, curiously enough, passage through the horizon can be unremarkable (if the black hole is very big). There are no sign posts indicating to Bob that he has passed the point of no return, and his books remain intact. Now suppose Bob scribbles some notes in the margins of his book. What happens to this information?

Here there is a diversity of views. Some suggest that this information, too, is radiated away through the Hawking process and the black hole simply disappears. Some suggest that quantum physics makes the event horizon penetrable so that some information is radiated by the Hawking process but some escapes directly. Yet others suggest that the information is copied; one copy is radiated away and the other strikes the singularity, entering a new section of space-time that is causally disconnected from observers outside the black hole, so the two copies never meet.

Theorists have recently developed a number of new theoretical tools to attack the problem and are hard at work. Although the subject lies in the domain of quantum gravity, the implications for other fields, including my own, cosmology, will be profound. The answer will shape any future formulation of the laws of thermodynamics, quantum gravity and unified field theory. Since scrambling information, a.k.a., the entropy, determines the arrow of time, the results may inform us how time may have first emerged at the cosmic singularity known as the big bang. Or, if it proves possible for copies to bounce from the black hole singularity to a separate piece of space time, the same may apply to an even more famous singularity, the big bang. This would lend support to recent ideas suggesting that the large scale properties of the universe were shaped by events before the big bang and these conditions (a form of information) were transmitted across the cosmic singularity into a new phase of expansion. In fact, if information is forever preserved across singularities, the universe may undergo regularly repeating cycles of big bangs, expansion, and big crunches, forever into the past and into the future. To me, a breakthrough with these kinds of implications would be the ultimate game-changer.



- PAGE 4 -


MARK PAGEL
Evolutionary Biology, Reading University, England; External Professor, Santa Fe Institute, NM

WE ARE LEARNING TO MAKE PHENOTYPES

We all develop from a single cell known as a zygote. This zygote divides and becomes two cells, then four, eight and so on. At first, most of the cells are alike, but as this division goes on something wondrous occurs: the cells begin to commit themselves to adopting different fates as eyes or ears, or livers or kidneys, or brains and blood cells. Eventually they produce a body of immense and unimaginable complexity, making things like supercomputers and space shuttles look like Lego toys. No one knows how they do it. No one is there to tell the cells how to behave, there is no homunculus directing cellular traffic, and no template to work to. It just happens.

If scientists could figure out how cells enact this miracle of development they could produce phenotypes — the outward form of our bodies — at will and from scratch, or at least from a zygote. This, or something close to it, will happen in our lifetimes. When we perfect it — and we are well on the way — we will be able to recreate ourselves, even redefine the nature of our lives.

The problem is that development isn't just a matter of finding a cell and getting it to grow and divide. As our cells differentiate into our various body parts they lose what is known as their 'potency', they forget how to go back to their earlier states where, like the zygote, all fates are possible. When we cut ourselves the skin nearby knows how to grow back, erasing all or most of the damage. But we can only do this on a very local scale. If you cut off your arm it does not grow back. What scientists are learning bit by bit to do is how to reverse cells back to their earlier potent states, how to re-program them so they could replace a limb.

Every year brings new discoveries and new successes. Cloning is one of the more visible. At the moment most cloning is a bit of a cheat, achieved by taking special cells from an adult animal's body that still retain some of their potency. But this will change as cell re-programming becomes possible, and the consequences could be alarming. Someone might be able to clone you by collecting a bit of your hair or other cells left behind when you touch something or sit somewhere. Why someone would want to do this — and wait for you to grow up — might limit this in practice but it could happen. You could become your own "father" or at least a very grown up twin.

More in the realm of the everyday and of real consequence is that once we can re-program cells, whole areas of science and medicine, including aging, injury and disease will vanish or become unimportant. All of the contentious work on 'embryonic stem cells' that regularly features in debates about whether it is moral to use embryos in research exists solely because scientists want a source of 'totipotent' cells, cells that haven't committed themselves to a fate. Embryos are full of them. Scientists aren't interested in embryonic stem cells per se, they simply want totipotent cells. Once scientists acquire the ability to return cells to their totipotent state, or even what is known as a 'multi-potent' state — a cell that is not quite yet fully committed — all this stem cell research will become unnecessary. This could happen within a decade.

School children learn that some lizards and crabs can re-grow limbs. What they are not taught is that this is because their cells retain multi- or even toti-potency. Because ours don't, this makes car crashes, ski accidents, gun shot wounds and growing old a nuisance. But once we unlock the door of development, we will be able to re-grow our limbs, heal our wounds and much more. Scientists will for once make the science-fiction writers look dull. The limbs (and organs, nerves, body parts, etc) that we re-grow will be real, making those bionic things like Anakin Skywalker gets fitted with after a light-sabre accident seem primitive. This will make transplants obsolete or just temporary, and things like heart disease will be treatable by growing new hearts. Nerve damage and paralysis will be reversible and some brain diseases will become treatable. Some of these things are already happening as scientists inch-by-inch figure out how to re-program cells.

If these developments are not life changing enough, they will, in the longer-term usher in a new era in which our minds, the thing that we think of as "us", can become separated from our body, or nearly separated anyway. I don't suggest we will be able to transplant our mind to another body, but we will be able to introduce new body parts into existing bodies with a resident mind. With enough such replacements, we will become potentially immortal: like ancient buildings that exist only because over the centuries each of their many stones has been replaced. An intriguing aspect of re-programming cells is that they can be induced to 'forget' how old they are. Aging will become a thing of the past if you can afford enough new pieces. We will then discover the extent to which our minds arise from perceptions of our bodies and the passage of time. If you give an old person the body of a teenager do they start to behave and think like one? Who knows, but it will be game-changing to find out.


BRIAN GOODWIN
Biologist, Schumacher College, Devon, UK; Author, How The Leopard Changed Its Spots

THE ORGANISM ITSELF AS THE EMERGENT MEANING

I anticipate that biology will go through a transforming revelation/revolution that is like the revolution that happened in physics with the development of quantum mechanics nearly 100 years ago. In biology this will involve the realisation that to make sense of the complexity of gene activity in development, the prevailing model of local mechanical causality will have to be abandoned. In its place we will have a model of interactive relationships within gene transcription networks that is like the pattern of interactions between words in a language, where ambiguity is essential to the creation of emergent meaning that is sensitive to cultural history and to context. The organism itself is the emergent meaning of the developmental process as embodied form, sensitive to both historical constraint within the genome and to environmental context, as we see in the adaptive creativity of evolution. What contemporary studies have revealed is that genes are not independent units of information that can be transferred between organisms to alter phenotypes, but elements of complex networks that act together in a morphogenetic process that produces coherent form and function as embodied meaning.

A major consequence that I see of this revelation in biology is the realisation that the separation we have made between human creativity as expressed in culture, and natural creativity as expressed in evolution, is mistaken. The two are much more deeply related than we have previously recognised. That humans are embedded in and dependent on nature is something that no-one can deny. This has become dramatically evident recently as our economic system has collapsed, along with the collapse of many crucial ecosystems, due to our failure to integrate human economic activity as a sustainable part of Gaian regulatory networks. We now face dramatic changes in the climate that require equally dramatic changes in our technologies connected with energy generation, farming, travel, and human life-style in general.

On the other hand, the recognition that culture is embedded in nature is not so evident but will, I believe, emerge as part of the biological revelation/revolution. Biologists will realise that all life, from bacteria to humans, involves a creative process that is grounded in natural languages as the foundation of their capacity for self-generation and continuous adaptive transformation. The complexity of the molecular networks regulating gene activity in organisms reveals a structure and a dynamic that has the self-similar characteristics and long-range order of languages. The coherent form of an organism emerges during its development as the embodied meaning of the historical genetic text, created through the process of resolving ambiguity and multiple possibilities of form into appropriate functional order that reflects sensitivity to context. Such use of language in all its manifestations in the arts and the sciences is the essence of cultural creativity.

In conclusion, I see the deep conceptual changes that are currently happening in biology as a prelude and accompaniment to the cultural changes that are occurring in culture, facilitating these and ushering in a new age of sustainable living on the planet.


CARLO ROVELLI
Physicist, Université de la Mediterrané (Marseille, France); Author, Quantum Gravity

AND IF THE BIG CHANGE DIDN'T ARRIVE?

I grew up expecting that, when adult, I'd travel to Mars. I expected cancer and the flu — and all illnesses — to be cured, robots taking care of labor, the biochemistry of life fully unraveled, the possibility of recreating damaged organs in every hospital, the nations of the Earth living prosperously in peace thanks to new technology, and physics having understood the center of a black hole. I expected great changes, that did not came. Let's be open minded: it is still possible for them to come. It is possible for unexpected advances to change everything — it has happened in the past. But — let's indeed be open minded — it is also possible that big changes would not come.

Maybe I am biased by my own research field, theoretical physics. I grew up in awe for the physics of the second half of the XIX century and the first third of the XX century. What a marvel! The discovery of the electromagnetic field and waves, understanding thermodynamics with probability, special relativity, quantum mechanics, general relativity... Curved spacetimes, probability waves and black holes. What a feast! The world transforming every 10 years under our eyes; reality becoming more subtle, more beautiful. Seeing new worlds. I got into theoretical physics. What has happened big in the last 30 years? We are not sure. Perhaps not much. Big dreams, like string theory and multi-universes, but are they credible? We do not know. Perhaps the same passion that charmed me towards the future has driven large chunks of today's research into useless dead-end dreams. Maybe not. Maybe we are really understanding what happened before the Big Bang (a "Big Bounce"?) and what takes place deep down at the Planck scale ("loops"? space and time loosing their meaning?). Let's be open to the possibility we are getting there — let's work hard to get there. But let's also be ready to recognize that perhaps we are not there. Perhaps our dreams are just that: dreams. Too often I have been hearing that somebody is "on the brink of" the great leap ahead. I now tend to get asleep when I hear "on the brink of". In physics it is 15 years that I hear that we are "on the brink of observing supersymmetry". Please weak me up when we are actually there.

I do not want to sound pessimistic. I just want to put a word of caution in. Maybe what really changes everything is not something that sounds so glamourous. What did really change everything in the past? Here are two examples. Until no more than a couple of centuries ago, 95% of humanity worked the countryside as peasants. That is, humanity needed the labour of 95 out of 100 of its members just to feed the group. This left happy few for doing everything else. Today only a few percent of the humans work the fields. A few are enough to feed everybody else. This means that the large majority of us, including me and most probably you, my reader, are free to do something else, participating in constructing the world we inhabit, a better one, perhaps. What made such a huge change in our lives possible? Mostly, just one technological tool: the tractor. The humble rural machine has changed our life perhaps more than the wheel or electricity. Another example? Hygiene. Our life expectancy has nearly doubled from little more than washing hands and taking showers. Change comes often from where it is not expected. The famous note from the IBM top management at the beginning of the computer history estimated that: "there is no market for more than a few dozens of computers in the world".

So, what is my moral? Making predictions is difficult, of course, especially about the future. It is good to dream about big changes, actively seek them and be open minded to them. Otherwise we are stuck here. But let us not get blinded by hopes. Dreams and hopes of humanity sometimes succeed, sometime fail big. The century just ended has shown us momentous examples of both. The Edge question is about what will change everything, which I'll see in my lifetime: and if the answer was: "nothing"? Are we able to discern hype from substance? Dolly may be scientifically important, but I tend to see it just as a funny-born twin-sister: she hasn't changed much in my life, yet. Will she really?


JONATHAN HAIDT
Psychologist, University of Virginia; Author, The Happiness Hypothesis

FASTER EVOLUTION MEANS MORE ETHNIC DIFFERENCES

The most offensive idea in all of science for the last 40 years is the possibility that behavioral differences between racial and ethnic groups have some genetic basis. Knowing nothing but the long-term offensiveness of this idea, a betting person would have to predict that as we decode the genomes of people around the world, we're going to find deeper differences than most scientists now expect. Expectations, after all, are not based purely on current evidence; they are biased, even if only slightly, by the gut feelings of the researchers, and those gut feelings include disgust toward racism..

A wall has long protected respectable evolutionary inquiry from accusations of aiding and abetting racism. That wall is the belief that genetic change happens at such a glacial pace that there simply was not time, in the 50,000 years since humans spread out from Africa, for selection pressures to have altered the genome in anything but the most trivial way (e.g., changes in skin color and nose shape were adaptive responses to cold climates). Evolutionary psychology has therefore focused on the Pleistocene era – the period from about 1.8 million years ago to the dawn of agriculture — during which our common humanity was forged for the hunter-gatherer lifestyle.

But the writing is on the wall. Russian scientists showed in the 1990s that a strong selection pressure (picking out and breeding only the tamest fox pups in each generation) created what was — in behavior as well as body — essentially a new species in just 30 generations. That would correspond to about 750 years for humans. Humans may never have experienced such a strong selection pressure for such a long period, but they surely experienced many weaker selection pressures that lasted far longer, and for which some heritable personality traits were more adaptive than others. It stands to reason that local populations (not continent-wide "races") adapted to local circumstances by a process known as "co-evolution" in which genes and cultural elements change over time and mutually influence each other. The best documented example of this process is the co-evolution of genetic mutations that maintain the ability to fully digest lactose in adulthood with the cultural innovation of keeping cattle and drinking their milk. This process has happened several times in the last 10,000 years, not to whole "races" but to tribes or larger groups that domesticated cattle.

Recent "sweeps" of the genome across human populations show that hundreds of genes have been changing during the last 5-10 millennia in response to local selection pressures. (See papers by Benjamin Voight, Scott Williamson, and Bruce Lahn). No new mental modules can be created from scratch in a few millennia, but slight tweaks to existing mechanisms can happen quickly, and small genetic changes can have big behavioral effects, as with those Russian foxes. We must therefore begin looking beyond the Pleistocene and turn our attention to the Holocene era as well – the last 10,000 years. This was the period after the spread of agriculture during which the pace of genetic change sped up in response to the enormous increase in the variety of ways that humans earned their living, formed larger coalitions, fought wars, and competed for resources and mates.

The protective "wall" is about to come crashing down, and all sorts of uncomfortable claims are going to pour in. Skin color has no moral significance, but traits that led to Darwinian success in one of the many new niches and occupations of Holocene life — traits such as collectivism, clannishness, aggressiveness, docility, or the ability to delay gratification — are often seen as virtues or vices. Virtues are acquired slowly, by practice within a cultural context, but the discovery that there might be ethnically-linked genetic variations in the ease with which people can acquire specific virtues is — and this is my prediction — going to be a "game changing" scientific event. (By "ethnic" I mean any group of people who believe they share common descent, actually do share common descent, and that descent involved at least 500 years of a sustained selection pressure, such as sheep herding, rice farming, exposure to malaria, or a caste-based social order, which favored some heritable behavioral predispositions and not others.)

I believe that the "Bell Curve" wars of the 1990s, over race differences in intelligence, will seem genteel and short-lived compared to the coming arguments over ethnic differences in moralized traits. I predict that this "war" will break out between 2012 and 2017.

There are reasons to hope that we'll ultimately reach a consensus that does not aid and abet racism. I expect that dozens or hundreds of ethnic differences will be found, so that any group — like any person — can be said to have many strengths and a few weaknesses, all of which are context-dependent. Furthermore, these cross-group differences are likely to be small when compared to the enormous variation within ethnic groups and the enormous and obvious effects of cultural learning. But whatever consensus we ultimately reach, the ways in which we now think about genes, groups, evolution and ethnicity will be radically changed by the unstoppable progress of the human genome project.


ANDY CLARK
Philosopher and Cognitive Scientist, University of Edinburgh; Author, Supersizing the Mind

CELEBRATORY SELF RE-ENGINEERING

What will change everything is the onset of celebratory species self re-engineering.

The technologies are pouring in, from wearable, implantable, and pervasive computing, to the radical feature blends achieved using gene transfer techniques, to thought-controlled cursors freeing victims of locked-in syndrome, to funkier prosthetic legs able to win track races, and on to the humble but transformative iPhone.

But what really matters is the way we are, as a result of this tidal wave of self- re-engineering opportunity, just starting to know ourselves: not as firmly bounded biological organisms but as delightfully reconfigurable nodes in a flux of information, communcation, and action. As we learn to celebrate our own potential, we will embrace ever-more-dramatic variations in bodily form and in our effective cognitive profiles. The humans of the next century will be vastly more heterogeneous, more varied along physical and cognitive dimensions, than those of the past as we deliberately engineer a new Cambrian explosion of body and mind.


LEO CHALUPA
Ophthalmologist and Neurobiologist, University of California, Davis

CONTROLLING BRAIN PLASTICITY

In the 1960s movie "The Graduate" a young Dustin Hoffman is advised to go into plastics, presumably because that will be the next big thing.

Today, one might well advise the young person planning to pursue a degree in medicine or the biological sciences to go into brain plasticity. This refers to the fact that neurons are malleable throughout life, capable of being shaped by external experiences and endogenous events.

Recent imaging studies of single neurons have revealed that specialized parts of nerve cells, termed dendritic spines are constantly undergoing a process of rapid expansion and retraction. While brain cells are certainly capable of structural and functional changes throughout life, an extensive scientific literature has shown that plasticity in the nervous system is greatest early in development, during the so-called critical periods. This accounts for the marvelous ability of children to rapidly master various skills at different developmental stages. Toddlers have no difficulty in learning two, three and even more languages, and most adolescents can learn to ski black diamond slopes much before their middle-aged parents. The critical periods underlying such learning reflect the high degree of plasticity exhibited by specific brain circuits during the first two decades of life.

In recent years, developmental neurobiologists have made considerable progress in unraveling the myriad factors underlying the plasticity of neurons in the developing brain. For instance, a number of studies have now demonstrated that it is the formation of inhibitory circuits in the cortex that causes decreased plasticity in the maturing visual system. While no single event can entirely explain brain plasticity, progress is being attained at a rapid pace, and I am convinced that in my lifetime we will be able to control the level of plasticity exhibited by mature neurons.

Several laboratories have already discovered ways to manipulate the brain in ways to make mature neurons as plastic as during early development. Such studies have been done using genetically engineered mice with either a deletion or an over-expression of specific genes known to control plasticity during normal development. Moreover, drug treatments have now been found to mimic the changes observed in these mutant mice.

In essence this means that the high degree of brain plasticity normally evident only during early development can now be made to occur throughout the life span. This is undoubtedly a game changer in the brain sciences. Imagine being able to restore the plasticity of neurons in the language centers of your brain, enabling you to learn any and all languages effortlessly and at a rapid pace. The restoration of neuronal plasticity would also have important clinical implications since unlike in the mature brain, connections in the developing brain are capable of sprouting (i.e. new growth). For this reason, this technology could provide a powerful means to combat loss of neuronal connections, including those resulting from brain injury as well as various disease states.

I am optimistic that these treatments will be forthcoming in my lifetime. Indeed a research group in Finland is about to begin the first clinical study to assess the ability of drug treatments to restore plasticity to the visual system of adult humans. If successful this would provide a means for treating amblyopia in adults, a prevalent disorder of the visual system, which today can only be treated in young children whose visual cortex is still plastic.

Still there are a number of factors will need to be worked out before the restoration of neuronal plasticity becomes a viable procedure. For one thing, it will be necessary to devise a means of targeting specific groups of neurons, those controlling a function that one wants to attain enhanced plasticity. Many people might wish to have a brain made capable of effortlessly learning foreign languages, but few would be pleased if this were accompanied by a vocabulary limited to babbling sounds, not unlike those of my granddaughter who is beginning to learn to speak English and Ukrainian.


LAURENCE C. SMITH
Professor of Geography and Earth & Space Sciences, UCLA

WEST ANTARCTICA AND SEVEN OTHER SLEEPING GIANTS

In the classic English fable Jack and the Beanstalk, the intrepid protagonist risks being devoured on sight in order to repeatedly raid the home of a flesh-eating giant for gold. All goes well until the snoring giant awakens and gives furious chase. But Jack beats him back down the magic beanstalk and chops it down with an axe, toppling the descending cannibal to its death. Jack thus wins back his life plus substantial economic profit from his spoils.

Industrialized society has also reaped enormous economic and social benefit from fossil fuels, so far without rousing any giants. But as geoscientists, my colleagues and I devote much of our time to worrying about whether they might be slumbering in the Earth's climate system.

We used to think climate worked like a dial — slow to heat up and slow to cool down — but we've since learned it can also act like a switch. Twenty years ago anyone who hypothesized an abrupt, show-stopping event — a centuries-long plunge in air temperature, say, or the sudden die-off of forests — would have been laughed off. But today, an immense body of empirical and theoretical research tells us that sudden awakenings are dismayingly common in climate behavior.

Ancient records preserved in tree rings, sediments, glacial ice layers, cave stalactites, and other natural archives tells us that for much of the past 10,000 years — the time when our modern agricultural society evolved — our climate was remarkably stable. Before then it was it was capable of wild fluctuations, even leaping eighteen degrees Fahrenheit in ten years. That's as if the average temperature in Minneapolis warmed to that of San Diego in a single decade.

Even during the relative calm of recent centuries, we find sudden lurches that exceed anything in modern memory. Tree rings tell us that in the past 1,000 years, the western United States has seen three droughts at least as bad as the Dust Bowl but lasting three to seven times longer. Two of them may have helped collapse past societies of the Anasazi and Fremont people.

The mechanisms behind such lurches are complex but decipherable. Many are related to shifting ocean currents that slosh around pools of warm or cool seawater in quasi-predictable ways. The El Niño/La Niña phenomenon, which redirects rainfall patterns around the globe, is one well-known example. Another major player is the Atlantic thermohaline circulation (THC), a massive density-driven "heat conveyor belt" that carries tropical warmth northwards via the Gulf Stream. The THC is what gifts Europe with relatively balminess despite being as far north as some of Canada's best polar bear habitat.

If the THC were to weaken or halt, the eastern U.S. and Europe would become something like Alaska. While over-sensationalized by The Day After Tomorrow film and a scary 2003 Pentagon document imagining famines, refugees, and wars, a THC shutdown nonetheless remains an unlikely but plausible threat. It is the original sleeping giant of my field.

Unfortunately, we are discovering more giants that are probably lighter sleepers than the THC. Seven others — all of them potential game-changers — are now under scrutiny: (1) the disappearance of summer sea-ice over the Arctic Ocean, (2) increased melting and glacier flow of the Greenland ice sheet, (3) "unsticking" of the frozen West Antarctic Ice Sheet from its bed, (4) rapid die-back of Amazon forests, (5) disruption of the Indian Monsoon, (6) release of methane, an even more potent greenhouse gas than carbon dioxide, from thawing frozen soils, and (7) a shift to a permanent El Niño-like state. Like the THC, should any of these occur there would be profound ramifications — like our food production, the extinction and expansion of species, and the inundation of coastal cities.

To illustrate, consider the Greenland and Antarctic ice sheets. The water stored in them is enormous, enough to drown the planet under more than 200 feet of water. That will not happen anytime soon but even a tiny reduction in their extent — say, five percent — would significantly alter our coastline. Global sea level is already rising about one-third of a centimeter every year and will reach at least 18 to 60 centimeters higher just one long human lifetime from now, if the speeds at which glaciers are currently flowing from land to ocean remain constant. But at least two warming-induced triggers might speed them up: percolation of lubricating meltwater down to the glaciers' beds; and the disintegration of floating ice shelves that presently pin glaciers onto the continent. If these giants awaken happen our best current guess is 80 to 200 centimeters of sea level rise. That's a lot of water. Most of Miami would either be surrounded by dikes or underwater.

Unfortunately, the presence of sleeping giants makes the steady, predictable growth of anthropogenic greenhouse warming more dangerous, not less. Alarm clocks may be set to go off, but we don't what their temperature settings are. The science is too new, and besides we'll never know for sure until it happens. While some economists predicted that rising credit-default swaps and other highly leveraged financial products might eventually bring about an economic collapse, who could have foreseen the exact timing and magnitude of late 2008? Like most threshold phenomena it is extremely difficult to know just how much poking is needed to disturb sleeping giants. Forced to guess, I'd mutter something about decades, or centuries, or never. On the other hand, one might be stirring already: In September 2007, then again in 2008, for the first time in memory nearly 40% of the later-summer sea ice in the Arctic Ocean abruptly disappeared.

Unlike Jack, the eyes of scientists are slow to adjust to the gloom. But we are beginning to see some outlines and unfortunately, discern not one but many sleeping forms. What is certain is that our inexorable loading of the atmosphere with heat-trapping greenhouse gases increases the likelihood that one or more of them will wake up.


ALISON GOPNIK
Psychologist, UC, Berkeley; Author, The Scientist in the Crib

NEVER-ENDING CHILDHOOD

The world is transforming from an agricultural and manufacturing economy to an information economy. This means that people will have to learn more and more. The best way to make it happen is to extend the period when we learn the most — childhood. Our new scientific understanding of neural plasticity and gene regulation, along with the global spread of schooling, will make that increasingly possible. We may remain children forever — or at least for much longer.

Humans already have a longer period of protected immaturity — a longer childhood — than any other species. Across species, a long childhood is correlated with an evolutionary strategy that depends on flexibility, intelligence and learning. There is a developmental division of labor. Children get to learn freely about their particular environment without worrying about their own survival — caregivers look after that. Adults use what they learn as children to mate, predate, and generally succeed as grown-ups in that environment. Children are the R & D department of the human species. We grown-ups are production and marketing. We start out as brilliantly flexible but helpless and dependent babies, great at learning everything but terrible at doing just about anything. We end up as much less flexible but much more efficient and effective adults, not so good at learning but terrific at planning and acting.

These changes reflect brain changes. Young brains are more connected, more flexible and more plastic, but less efficient. As we get older, and experience more, our brains prune out the less-used connections and strengthen the connections that work. Recent developments in neuroscience show that this early plasticity can be maintained and even reopened in adulthood. And, we've already invented the most unheralded but most powerful brain-altering technology in history — school.

For most of human history babies and toddlers used their spectacular, freewheeling, unconstrained learning abilities to understand fundamental facts about the objects, people and language around them — the human core curriculum. At about 6 children also began to be apprentices. Through a gradual process of imitation, guidance and practice they began to master the particular adult skills of their particular culture — from hunting to cooking to navigation to childrearing itself. Around adolescence motivational changes associated with puberty drove children to leave the protected cocoon and act independently. And by that time their long apprenticeship had given children a new suite of executive abilities — abilities for efficient action, planning, control and inhibition, governed by the development of prefrontal areas of the brain. By adolescence children wanted to end their helpless status and act independently and they had the tools to do so effectively.

School, a very recent human invention, completely alters this program. Schooling replaces apprenticeship. School lets us all continue to be brilliant but helpless babies. It lets us learn a wide variety of information flexibly, and for its own sake, without any immediate payoff. School assumes that learning is more important than doing, and that learning how to learn is most important of all. But school is also an extension of the period of infant dependence — since we don't actually do anything useful in school, other people need to take care of us — all the way up to a Ph.D. School doesn't include the gradual control and mastery of specific adult skills that we once experienced in apprenticeship. Universal and extended schooling means that the period of flexible learning and dependence can continue until we are in our thirties, while independent active mastery is increasingly delayed.

Schooling is spreading inexorably throughout the globe. A hundred years ago hardly anyone went to school, even now few people are schooled past adolescence. A hundred years from now we can expect that most people will still be learning into their thirties and beyond. Moreover, the new neurological and genetic developments will give us new ways to keep the window of plasticity open. And the spread of the information economy will make genetic and neurological interventions, as well as educational and behavioral interventions, more and more attractive.

These accelerated changes have radical consequences. Schooling alone has already had a revolutionary effect on human learning. Absolute IQs have increased at an astonishing and accelerating rate, "the Flynn effect". Extending the period of immaturity indeed makes us much smarter and far more knowledgeable. Neurological and genetic techniques can accelerate this process even further. We all tend to assume that extending this period of flexibility and openness is a good thing — who would argue against making people smarter?

But there may be an intrinsic trade-off between flexibility and effectiveness, between the openness that we require for learning and the focus that we need to act. Child-like brains are great for learning, but not so good for effective decision-making or productive action. There is some evidence that adolescents even now have increasing difficulty making decisions and acting independently, and pathologies of adolescent action like impulsivity and anxiety are at all-time historical highs. Fundamental grown-up human skills we once mastered through apprenticeship, like cooking and caregiving itself, just can't be acquired through schooling. (Think of all those neurotic new parents who have never taken care of a child and try to make up for it with parenting books). When we are all babies for ever, who will be the parents? When we're all children who will be the grown-ups?


John D. Barrow
Physicist, Director, Millennium Mathematics Project, Cambridge; Author, 100 Essential Things You Didn't Know You Didn't Know

A VERY VERY GOOD BATTERY


LAWRENCE KRAUSS
Physicist, Director, Origins Initiative, Arizona State University; Author, Hiding in the Mirror

THE USE OF NUCLEAR WEAPONS AGAINST A CIVILIAN POPULATION

"With Nuclear Weapons, everything has changed, save our way of thinking."  So said Albert Einstein, sixty three years ago, following the Hiroshima and Nagasaki bombings at the end of World War II.  Having been forced to choose a single game changer, I have turned away from the fascinating scientific developments I might like to see, and will instead focus on the one game changer that I will hopefully never directly witness, but nevertheless expect will occur during my lifetime:  the use of nuclear weapons against a civilian population.  Whether used by one government against the population of another, or by a terrorist group, the detonation of even a small nuclear explosive, similar in size, for example, to the one that destroyed hiroshima, would produce an impact on the economies, politics, and lifestyles of the first world in a way that would make the impact of 9/11 seem trivial.   I believe the danger of nuclear weapons use remains one of the biggest dangers of this century.  It is remarkable that we have gone over 60 years without their use, but the clock is ticking.  I fear that Einstein's admonition remains just as true today as it did then, and I that we are unlikely to go another half century with impunity, at least without confronting the need for a global program of disarmament that goes far beyond the present current Nuclear Non-Proliferation, and strategic arms treaties.

Following forty years of Mutually Assured Destruction, with the two Superpowers like two scorpions in a bottle, each held at bay by the certainty of the destruction that would occur at the first whiff of nuclear aggression on the part of the other, we have become complacent.  Two generations have come to maturity in a world where nuclear weapons have not been used.  The Nuclear Non-Proliferation Treaty has been largely ignored, not just by nascent nuclear states like North Korea, or India and Pakistan, or pre-nuclear wannabies like Iran.  Together the United States and Russia possess 26,000 of the world's 27,000 known nuclear warheads.  This in spite of the NPT's strict requirement for these countries to significantly reduce their arsenals.   Each country has perhaps 1000 warheads on hair trigger full alert.  This in spite of the fact that there is no strategic utility at the current time associated with possessing so many nuclear weapons on alert.  

Ultimately, what so concerned Einstein, and is of equal concern today, is the fact that first use of nuclear weapons cannot be justified on moral or strategic grounds. Nevertheless, it may surprise some people to learn that the United States has no strict anti-first-use policy. In fact, in its 2002 Nuclear Posture Review, the U.S. declared that nuclear weapons "provide credible military options to deter a wide range of threats" including "surprising military developments."  

And while we spend $10 billion/yr on flawed ballistic missile defense systems against currently non-existent threats, the slow effort to disarm means that thousands of nuclear weapons remain in regions that are unstable, and which could, in principle, be accessed by well organized and well financed terrorist groups.  We have not spent a noticeable fraction of the money spent supposedly defending against ballistic missiles instead outfitting ports and airports to detect against possible nuclear devices smuggled into this country in containers. 

Will it take a nuclear detonation used against a civilian population to stir a change in thinking?  The havoc wreaked on what we now call the civilized world, no matter where a nuclear confrontation takes place, would be orders of magnitude greater than that which we have experienced since the Second World War.   Moreover, as recent calculations have demonstrated, even a limited nuclear exchange between, say India and Pakistan, could have a significant global impact for almost a decade on world climates and growing seasons.  

I sincerely hope that whatever initiates a global realization that the existence of large nuclear stockpiles throughout the world is a threat to everyone on the planet, changing the current blind business-as-usual mentality permeating global strategic planning, does not result from a nuclear tragedy.  But physics has taught me that the world is the way it is whether we like it or not.  And my gut tells me that to continue to ignore the likelihood that a game changer that exceeds our worst nightmares will occur in this century is merely one way to encourage that possibility.



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STEPHEN H. SCHNEIDER
Biologist; Climatologist, Stanford University; Author, Laboratory Earth

CONSERVING THE CLIMATE: WILL GREENLAND'S MELTING ICE THE DEAL?

Scientists have been talking about the risks of human induced climate changes for decades now in front of places like Congress, scientific conventions, media events, corporate board rooms, and at visible cultural extravaganzas like Live Earth. Yet, a half century after serious scientific concerns surfaced, the world is still far from a meaningful deal to implement actions to curb the threats by controlling the offending emissions.

The reason is obvious: controlling the basic activities that brought us our prosperity — burning fossil fuels — is not going to be embraced by those who benefit from using the atmosphere as a place to dump for free their tailpipe and smokestack effluents, nor will developing economies like China and India easily give up the techniques we used to get rich because of some threat perceived as distant and not yet certain. To be sure there is real action at local, state, national and international levels, but a game changing global deal is still far from likely. Documented impacts like loss of the Inuit hunting culture, small island states survival in the face of inexorable sea level rise, threats of species extinction in critical places like mountain tops, or a five fold increase in wild fires in the US West since 1970 have not been game changin — yet. What might change the game?

In order to give up something — the traditional pathway to wealth, burning coal oil and gas — nations will have to viscerally perceive they are getting something — protection from unacceptably severe impacts. The latter has been difficult to achieve because most scientific assessments are honest that along with many credible and major risks are many remaining uncertainties.

We cannot pin down whether sea levels will rise a few feet or a few meters in the next century or two — the former is nasty but relatively manageable with adaptation investments, the latter would mean abandoning coastline installations or cultures where a sizeable chunk of humanity lives and works. If we could show scientifically that such a threat was likely, it would be game changing in terms of motivating the kinds of compromises required to achieve the actions needed that are currently politically difficult to achieve.

This is where the potential for up to 7 meters of sea level rise stored as ice on Greenland will come in to tip us toward meaningful actions. Already Greenland is apparently melting at an unprecedented rate, and way faster than any of our theories or models predicted. But it can be — and has been — argued it is just a short term fluctuation since large changes in ice volume come and go typically on millennial timescales — though mounting evidence from ice cores says probably there is unprecedented melting going on right now. Another decade or two of such scientifically documented acceleration of melting could indeed imply we will get the unlucky outcome: meters of sea level rise in the time frame of human infrastructure lifetimes for ports and cities — to say nothing of vulnerable natural places like coastal wetlands etc.

Unfortunately, the longer we wait for more confident "proof" of game changing melt rates in Greenland (or West Antarctica as well, where another 5 meters potential sea level rise lurks), the higher the risk of passing a tipping point in which the melting becomes an unstoppable self-driven process. That game change occurrence would force unprecedented retreat from the sea, and a major abandonment or rebuilding of coastal civilization and loss of coastal wetlands. This is a gamble with "Laboratory Earth", that we can't afford to lose.


AUBREY DE GREY
Gerontologist; Chairman & Chief Science Officer. the Methuselah Foundation; Author, Ending Aging

THE UNMASKING OF TRUE HUMAN NATURE

Since I think I have a fair chance of living long enough to see the defeat of aging, it follows that I expect to live long enough to see many momentous scientific and technological developments. Does one such event stand out? Yes and no.

You don't have to be a futurophile, these days, to have heard of "the Singularity". What was once viewed as an oversimplistic extrapolation has now become mainstream: it is almost heterodox in technologically sophisticated circles not to take the view that technological progress will accelerate within the next few decades to a rate that, if not actually infinite, will so far exceed our imagination that it is fruitless to attempt to predict what life will be like thereafter.

Which technologies will dominate this march? Surveying the torrent of literature on this topic, we can with reasonable confidence identify three major areas: software, hardware and wetware. Artificial intelligence researchers will, numerous experts attest, probably build systems that are "recursively self-improving" — that understand their own workings well enough to design improvements to themselves, thereby bootstrapping to a state of ever more unimaginable intellectual performance.

On the hardware side, it is now widely accepted as technically feasible to build structures in which every atom is exactly where we wish it to be. The positioning of each atom will be painstaking, so one might view this as of purely academic interest — if not for the prospect of machines that can build copies of themselves. Such "assemblers" have yet to be completely designed, let alone built, but cellular automata research indicates that the smallest possible assembler is probably quite simple and small. The advent of such devices would rather thoroughly remove the barrier to practicability that arises from the time it takes to place each atom: exponentially accelerating parallelism is not to be sneezed at.

And finally, when it comes to biology, the development of regenerative medicine to a level of comprehensiveness that can give a few extra decades of healthy life to those who are already in middle age will herald a similarly accelerating sequence of refinements — not necessarily accelerating in terms of the rate at which such therapies are improved, but in the rate at which they diminish our risk of succumbing to aging at any age, as I've described using the concept of "longevity escape velocity".

I don't single out one of these areas as dominant. They're all likely to happen, but all have some way to go before their tipping point, so the timeframe for their emergence is highly speculative. Moreover, each of them will hasten the others: superintelligent computers will advance all technological development, molecular machines will surpass enzymes in their medical versatility, and the defeat of our oldest and most implacable foe (aging) will raise our sights to the point where we will pursue other transformative technologies seriously as a society, rather than leaving them to a few rare visionaries. Thus, any of the three — if they don't just wipe us all out, but unlike Martin Rees I personally think that is unlikely — could be "the one".

Or... none of them. And this is where I return to the Singularity. I'll get to human nature soon, fear not.

When I discuss longevity escape velocity, I am fond of highlighting the history of aviation. It took centuries for the designs of da Vinci (who was arguably not even the first) to evolve far enough to become actually functional, and many confident and smart engineers were proven wrong in the meantime. But once the decisive breakthrough was made, progress was rapid and smooth. I claim that this exemplifies a very general difference between fundamental breakthroughs (unpredictable) and incremental refinements (remarkably predictable).

But to make my aviation analogy stick, I of course need to explain the dramatic lack of progress in the past 40 years (since Concorde). Where are our flying cars? My answer is clear: we haven't developed them because we couldn't be bothered, an obstacle that is not likely to occur when it comes to postponing aging. Progress only accelerates while provided with impetus from human motivation. Whether it's national pride, personal greed, or humanitarian concern, something — someone — has to be the engine room.

Which brings me, at last, to human nature. The transformative technologies I have mentioned will, in my view, probably all arrive within the next few decades — a timeframe that I personally expect to see. And we will use them, directly or indirectly, to address all the other slings and arrows that humanity is heir to: biotechnology to combat aging will also combat infections, molecular manufacturing to build unprecedentedly powerful machines will also be able to perform geoengineering and prevent hurricanes and earthquakes and global warming, and superintelligent computers will orchestrate these and other technologies to protect us even from cosmic threats such as asteroids — even, in relatively short order, nearby supernovae. (Seriously.) Moreover, we will use these technologies to address any irritations of which we are not yet even aware, but which grow on us as today's burdens are lifted from our shoulders. Where will it all end?

You may ask why it should end at all — but it will. It is reasonable to conclude, based on the above, that there will come a time when all avenues of technology will, roughly simultaneously, reach the point seen today with aviation: where we are simply not motivated to explore further sophistication in our technology, but prefer to focus on enriching our and each other's lives using the technology that already exists. Progress will still occur, but fitfully and at a decelerating rather than accelerating rate. Humanity will at that point be in a state of complete satisfaction with its condition: complete identity with its deepest goals. Human nature will at last be revealed.


DONALD D. HOFFMAN
Cognitive Scientist, UC, Irvine; Author, Visual Intelligence

THE LAPTOP QUANTUM COMPUTER

Everything will change with the advent of the laptop quantum computer (QC). The transition from PCs to QCs will not merely continue the doubling of computing power, in accord with Moore's Law. It will induce a paradigm shift, both in the power of computing (at least for certain problems) and in the conceptual frameworks we use to understand computation, intelligence, neuroscience, social interactions, and sensory perception.

Today's PCs depend, of course, on quantum mechanics for their proper operation. But their computations do not exploit two computational resources unique to quantum theory: superposition and entanglement. To call them computational resources is already a major conceptual shift. Until recently, superposition and entanglement have been regarded primarily as mathematically well-defined by psychologically incomprehensible oddities of the quantum world — fodder for interminable and apparently unfruitful philosophical debate. But they turn out to be more than idle curiosities. They are bona fide computational resources that can solve certain problems that are intractable with classical computers. The best known example is Peter Shor's quantum algorithm which can, in principle, break encryptions that are impenetrable to classical algorithms.

The issue is the "in principle" part. Quantum theory is well established and quantum computation, although a relatively young discipline, has an impressive array of algorithms that can in principle run circles around classical algorithms on several important problems. But what about in practice? Not yet, and not by a long shot. There are formidable materials-science problems that must be solved — such as instantiating quantum bits (qubits) and quantum gates, and avoiding an unwanted noise called decoherence — before the promise of quantum computation can be fulfilled by tangible quantum computers. Many experts bet the problems can't adequately be solved. I think this bet is premature. We will have laptop QCs, and they will transform our world.

When laptop QCs become commonplace, they will naturally lead us to rethink the notion of intelligence. At present, intelligence is modeled by computations, sometimes simple and sometimes complex, that allow a system to learn, often by interacting with its environment, how to plan, reason, generalize and act to achieve goals. The computations might be serial or parallel, but they have heretofore been taken to be classical.

One hallmark of a classical computation is that it can be traced, i.e., one can in principle observe the states of all the variables at each step of the computation. This is helpful for debugging. But one hallmark of quantum computations is that they cannot in general be traced. Once the qubits have been initialized and the computation started, you cannot observe intermediate stages of the computation without destroying it. You aren't allowed to peak at a quantum computation while it is in progress.

The full horsepower of a quantum computation is only unleashed when, so to speak, you don't look. This is jarring. It clashes with our classical way of thinking about computation. It also clashes with our classical notion of intelligence. In the quantum realm, intelligence happens when you don't look. Insist on looking, and you destroy this intelligence. We will be forced to reconsider what we mean by intelligence in light of quantum computation. In the process we might find new conceptual tools for understanding those creative insights that seem to come from the blue, i.e., whose origin and development can't seem to be traced.

Laptop QCs will make us rethink neuroscience. A few decades ago we peered inside brains and saw complex telephone switch boards. Now we peer inside brains and see complex classical computations, both serial and parallel. What will see once we have thoroughly absorbed the mind set of quantum computation? Some say we will still find only classical computations, because the brain and its neurons are too massive for quantum effects to survive. But evolution by natural selection leads to surprising adaptations, and there might in fact be selective pressures toward quantum computations.

One case in point arises in a classic problem of social interaction: the prisoner's dilemma. In one version of this dilemma, someone yells "FIre!" in a crowded theater. Each person in the crowd has a choice. They can cooperate with everyone else, by exiting in turn in an orderly fashion. Or they can defect, and bolt for the exit. Everyone cooperating would be best for the whole crowd; it is a so-called Pareto optimal solution. But defecting is best for each individual; it is a so-called Nash equilibrium.

What happens is that everyone defects, and the crowd as a whole suffers. But this problem of the prisoner's dilemma, viz., that the Nash equilibrium is not Pareto optimal, is an artifact of the classical computational approach to the dilemma. There are quantum strategies, involving superpositions of cooperation and defection, for which the Nash equilibrium is Pareto optimal. In other words, the prisoner's dilemma can be resolved, and the crowd as a whole needn't suffer if quantum strategies are available. If the prisoner's dilemma is played out in an evolutionary context, there are quantum strategies that drive all classical strategies to extinction. This is suggestive. Could there be selective pressures that built quantum strategies into our nervous systems, and into our social interactions? Do such strategies provide an alternative way to rethink the notion of altruism, perhaps as a superposition of cooperation and defection?

Laptop QCs will alter our view of sensory perception. Superposition seems to be telling us that our sensory representations, which carve the world into discrete objects with properties such as position and momentum, simply are an inadequate description of reality: No definite position or momentum can be ascribed to, say, an electron when it is not being observed. Entanglement seems to be telling us that the very act of carving the world into discrete objects is an inadequate description of reality: Two electrons, billions of light years apart in our sensory representations, are in fact intimately and instantly linked as a single entity.

When superposition and entanglement cease to be abstract curiosities, and become computational resources indispensable to the function of our laptops, they will transform our understanding of perception and of the relation between perception and reality.


James J. O'Donnell
Classicist; Provost, Georgetown University; Author, The Ruin of the Roman Empire

Africa

"Africa" is the short answer to this question. But it needs explanation.

Historians can't predict black swan game-changers any better than economists can. An outbreak of plague, a nuclear holocaust, an asteroid on collision course, or just an unassassinated pinchbeck dictator at the helm of a giant military machine — any of those can have transformative effect and will always come as a surprise.

But at a macro level, it's easier to see futures, just hard to time them. The expansion of what my colleague, the great environmental historian John McNeill, calls "the human web" to build a planet-wide network of interdependent societies is simply inevitable, but it's taken a long time. Rome, Persia, and ancient China built a network of empires stretching from Atlantic to Pacific, but never made fruitful contact with each other and their empire-based model of "globalization" fell apart in late antique times. A religion-based model kicked in then, with Christianity and Islam taking their swings: those were surprising developments, but they only went so far.

It took until early modern times and the development of new technologies for a real "world-wide web" of societies to develop. Even then, development was Euro-centric for a very long time. Now in our time, we've seen one great game-changer. In the last two decades, the Euro-centric model of economic and social development has been swamped by the sudden rise of the great emerging market nations: China, India, Brazil, and many smaller ones. The great hope of my youth — that "foreign aid" would help the poor nations bootstrap themselves — has come true, sometimes to our thinly-veiled disappointment: disappointment because we suddenly find ourselves competed with for steel and oil and other resources, suddenly find our products competed with by other economies' output, and wonder if we really wanted that game to change after all. The slump we're in now is the inevitable second phase of that expansion of the world community, and the rise that will follow is the inevitable third — and we all hope it comes quickly.

But a great reservoir or misery and possibility awaits: Africa. Humankind's first continent and homeland has been relegated for too long to disease, poverty, and sometimes astonishingly bad government. There is real progress in many places, but astonishing failures persist. That can't last. The final question facing humankind's historical development is whether we can bring the whole human family, including Africa's billion, can all achieve together sustainable levels of health and comfort.

When will we know? That's a scary question. One future timeline has us peaking now and subsiding, as we wrestle with the challenges we have made for ourselves, into some long period of not-quite-success, while Africa and the failed states of other continents linger in waiting for — what? Decades? Centuries? There are no guarantees about the future. But as we think about the financial crises of the present, we have to remember that what is at risk is not merely the comfort and prosperity of the rich nations but the very lives and opportunity for the poorest.


GREGORY BENFORD
Novelist; Co-founder & Chairman, Genescient' Author, The Sunborn

LIVE TO 150

I expect to see this happen, because I'll be living longer. Maybe even to 150, about 30 more years than any human is known to have lived.

I expect this because I've worked on it, seen the consequences of genomics when applied to the complex problem of our aging.

Since Aristotle, many scientists and even some physicians (who should know better) thought that aging arises from a few mechanisms that make our bodies deteriorate. Instead, the genomic revolution of the last decade now promises a true 21st Century path to extending longevity: follow the pathways.

Genomics now reveals what physicians intuited: the staggering complexity of aging pathophysiology among real clinical patients. We can't solve "the aging problem" using the standard research methods of cell biology, despite the great success such methods had with some other medical problems.

Aging is not a process of deterioration actively built by natural selection. Instead it arises from a lack of such natural selection in later adulthood. Not understanding this explains the age-old failures to explain or control aging and the chronic diseases underlying it.

Aging comes from multiple genetic deficiencies, not a single biochemical problem.

But now we have genomics to reveal all the genes in an organism. More, we can monitor how each and every one of them expresses in our bodies. Genomics, working with geriatric pathology, now unveils the intricate problems of coordination among aging organ systems. Population genetics illuminates aging's cause and so, soon enough, its control. Aging arises from interconnected complexity hundreds of times greater than cell biologists thought before the late 1990s.

The many-headed monster of aging can't be stopped by any vaccine or by supplying a single missing enzyme. There are no "master regulatory" genes, or avenues of accumulating damage. Instead, there any complex pathways that inevitably trade current performance for longterm decay. Eventually that evolutionary strategy catches up with us.

So the aging riddle is inherently genomic in scale. There is no biochemical or cellular necessity to aging — it arises from side effects of evolution, through natural selection. But this also means we can attack it by using directed evolution.

Michael Rose at UC Irvine has produced "Methuselah flies" that live over four times longer than control flies in the lab. He did this by not allowing their eggs to hatch, until half are dead, for hundreds of generations. Methuselah flies are more robust, not less, and so resist stress.

Methuselah flies genomics shows us densely overlapping pathways. Directed evolution uses these to enhance longevity. Since flies have about ¾ of their genes in common with us, this tells us much about our own pathways. We now know many of these pathways and can enhance their resistance to the many disorders of aging.

By finding substances that can enhance the action of those pathways, we have a 21st Century approach to aging. Such research is rapidly ongoing in private companies, including one I co-founded only three years ago. The field is moving fast. The genomic revolution makes the use of multi-pathway treatments to offset aging inevitable.

Knowledge comes first, then its use. Science yields engineering. Already there seems no fundamental reason why we cannot live to 150 years or longer. After all, nature has done quite well on her own. We know of a 4,800-year-old bristlecone pine, a 400 year old clam — plus whales, a tortoise and koi fish over 200 years old — all without technology. After all, these organisms use pathways we share, and can now understand.

It will take decades to find the many ways of acting on the longevity genes we already know. Nature spent several billion years developing these pathways; we must plumb them with smart modern tools. The technology emerging now acts on these basic pathways to immediately effect all types of organs. Traditionally, medicine focuses on disease by isolating and studying organs. Fair enough, for then. Now it is better to focus on entire organisms. Only genomics can do this. It looks at the entire picture.

Quite soon, simple pills containing designer supplements will target our most common disorders — cardiovascular, diabetes, neurological. Beyond that, the era of affordable, personal genomics makes possible designer supplements, now called neutrigenomics. Tailored to each personal genome, these can enforce the repair mechanisms and augmentations that nature herself provided to the genomically fortunate.

So…what if it works?

The prospect of steadily extending our lifespans terrifies some governments. These will yield, over time, to pressures to let us work longer — certainly far beyond the 65 years imposed by most European Union countries. Slowly it will dawn that vibrant old age is a boon, not a curse.

Living to 150 ensures that you take the long view. You're going to live in a future ecology, so better be sure it's livable. You'll need longterm investments, so think longterm. Social problems will belong to you, not some distant others, because problems evolve and you'll be around to see them.

Rather than isolating people, "old age" will lead to social growth. With robust health to go with longer lives, the older will become more socially responsible, bringing both experience and steady energy to bear.

We need fear no senioropolis of caution and withdrawal. Once society realizes that people who get educated in 20 years can use that education for another century or so, working well beyond 100, all the 20th Century social agenda vanishes. Nobody will retire at 65. People will switch careers, try out their dreams, perhaps find new mates and passions. We will see that experience can damp the ardent passions of glib youth, if it has a healthy body to work through. That future will be more mature, and richer for it.

All this social promise emerges from the genomic revolution. The 21st Century has scarcely begun, and already it looks as though most who welcomed it in will see it out–happily, after a good swim in the morning and a vigorous party that night, to welcome in the 22nd. The first person to live to 150 may be reading this right now.


STEVE NADIS
Science writer; Contributing Editor, Astronomy Magazine

DISCOVERING ANOTHER UNIVERSE IN OUR UNIVERSE

What would change everything? Well, if you think of the universe as everything, then something that changes the universe — or at least changes our whole conception of it — would change everything. So I think I’ll go with the universe (which is generally a safe pick when you want to cover all bases). I just have to figure out the thing that’s changing. And the biggest, most dramatic thing I can think of would be discovering another universe in our universe.

Now what exactly does that mean? To some extent, it comes down to definitions. If you define the universe as “all there is,” then the idea of discovering another universe doesn’t really make sense. But there are other ways of picturing this. And the way many cosmologists view it is that our universe is, in fact, an expanding bubble--an honest-to-god bubble with a wall and everything. Not so different from a soap bubble really, except for its size and longevity. For this bubble has kept it together for billions of years. And as viewed from the inside, it appears infinitely large. Even so, there’s still room for other bubbles out there--an infinite number of them--and they could appear infinitely large too.

I guess the picture I’m painting here has lots of bubbles. And it’s not necessarily wrong to think of them as different universes, because they could be made of entirely different stuff that obeys different physical laws and sits at a different general energy level (or vacuum state) than our bubble. The fact is, we can never see all of our own bubble, or even see its edge, let alone see another bubble that might be floating outside. We can only see as far as light will take us, and right now that’s about 13.7 billion light-years, which means we only get to observe a small portion of our bubble and nothing more. That’s why it’s fair to consider a bubble outside ours as a universe unto itself. It could be out there, just as real as ours, and we’ll never have any prospect of knowing about it. Unless, perchance, it makes a dramatic entrance into our world by summarily crashing into us.

This sounds like the stuff of fantasy, and it may well be, but I’m not just making it up. Because one of our leading theories in cosmology called inflation predicts — at least in some versions — that our bubble universe will eventually experience an infinite number of collisions with other bubble universes. The first question one might ask is could we withstand such a crash and live to tell about it? The small number of physicists and cosmologists who’ve explored this issue have concluded that in many cases we would survive, protected to some extent by the vastness of our bubble and its prodigious wall.

The next question to consider is whether we could ever see traces of such a collision? There’s no definitive answer to that yet, and until we detect the imprint of another bubble we won’t know for sure. But theorists have some pretty specific ideas of what we might see — namely, disk-shaped features lurking somewhere amidst the fading glow of Big Bang radiation known as the cosmic microwave background. And if we were to look at such a disk in gravitational waves, rather than in electromagnetic waves (which we should be able to do in the near future), we might even see it glow.

The probability of seeing a disk of this nature is hard to assess because it appears to be the product of three numbers whose values we can only guess at. One of those numbers has to do with the rate at which other bubbles are forming. The other two numbers have to do with the rate at which space is expanding both inside and outside our bubble. Since we don’t know how to get all these numbers by direct measurements, there doesn’t seem to be much hope of refining that calculation in the near-term. So our best bet, for now, may be trying to obtain a clearer sense of the possible observational signatures and then going out and looking. The good news is that we won’t need any new observatories in the sky. We can just sift through the available cosmic microwave data, which gets better every year, and see what turns up.

If we find another universe, I’m not sure exactly what that means. The one thing I do know is that it’s big. It should be of interest to everybody, though it will undoubtedly mean different things to different folks. One thing that I think most people will agree on is that the place we once called the universe is even grander and more complex than we ever imagined.


BARRY SMITH
Director, Institute of Philosophy, School of Advanced Study, University of London

Little Changes Make the Biggest Difference

Despite the inevitable decline in the environment brought by climate change, the advance of technology will steadily continue. Many pin their hopes on technological advances to lessen the worst effects of climactic upheaval and to smooth the transition between our dependence on fossil fuels and our eventual reliance on renewable energy sources. However, bit by bit, less dramatic advances in technology will take place, changing the world, and our experience of it, for ever.

It is tempting when thinking about developments that will bring fundamental change to look to the recent past. We think of the Internet and the cell phone. To lose contact with the former, even temporarily, can make one feel that one is suddenly stripped of a sense, like the temporary lose of one’s sight or hearing; while the ready supply of mobile phone technology has stimulated the demand to communicate. Why be alone anywhere? You can always summon someone’s company? Neither of these technologies is yet optimal, and either we, or they, will have to adapt to one another. The familiar refrain is that email increases our workload and that cell phones put us at the end of the electronic leash. Email can also be a surprisingly inflammatory medium, and cell phones can separate us from our surroundings, leaving us uneasy with these technologies. Can’t live with them, can’t live without them. So can future technology help, or is it we who will adapt?

Workers in A.I. used to dream of the talking typewriter and this is ever closer closer to being an everyday reality. Why write emails when you can dictate them? Why read them when you can listen to them being read to you, and do something else? And why not edit as you go, to speed up the act of replying? All this will come one day, no doubt, perhaps with emails being read in the personalized voice patterns of their senders. Will this cut down on the surprisingly inflammatory and provocative nature of email exchanges? Perhaps not.

However, the other indispensable device for communicating, the cell phone, is far from adaptive. We hear, unwanted, other people’s conversations. We lose our inhibitions and our awareness of our surroundings while straining to capture the nuances of the other’s speech; listing out for the subtle speech signals that convey mood and meaning, many of which are simply missing in this medium. Maybe this is why speakers are more ampliative on their cell phones, implicitly aware that less of them comes across. Face to face our attention is focused on many features of the talker. It is this multi-modal experience that can simultaneously provide so much. Without these cross-modal clues, we make a concentrated effort to tune in to what is happening elsewhere, often with dangerous consequences, as happens when drivers lose the keen awareness of their surroundings — even when using hands free sets. Could technology overcome these problems?

Here, I am reminded not of the recent past but of a huge change that occurred in the middle-ages when humans transformed their cognitive lives by learning to read silently. Originally, people could only read books by reading each page out loud. Monks would whisper, of course, but the dedicated reading by so many in an enclosed space must have been an highly distracting affair. It was St Aquinas who amazed his fellow believers by demonstrating that without pronouncing words he could retain the information he found on the page. At the time, his skill was seen as a miracle, but gradually human readers learned to read by keeping things inside and not saying the words they were reading out loud. From this simple adjustment, seemingly miraculous at the time, a great transformation of the human mind took place, and so began the age of intense private study so familiar to us now; whose universities where ideas could turn silently in large minds.

Will a similar transformation of the human mind come about in our time? Could there come a time when we intend to communicate and do so without talking out loud? If the answer is ‘yes’ a quiet public space would be restored where all could engage in their private conversations without disturbing others. Could it really happen? Recently, we have been amazed by how a chimpanzee running on a treadmill could control — for a short time — the movements of a synchronized robot running on a treadmill thousands of miles away. Here, we would need something subtly different but no less astounding: a way of controlling in thought, and committing to send, the signals in the motor cortex that would normally travel to our articulators and ultimately issue in speech sounds. A device, perhaps implanted or appended, would send the signals and another device in receivers would read them and stimulate similar movements or commands in their motor cortex, giving them the ability, through neural mimicry, to reproduce silently the speech sounds they would make if they were saying them. Could accent be retained? Maybe not, unless some way was found of coding separately, but usably, the information voice conveys about the size, age and sex of the speaker. However, knowing who was calling and knowing how they sounded may lead us to ‘hear’ their voice with the words understood.

Whether this could be done depends, in part, on whether Lieberman’s Motor Theory of Speech Perception is true, and it may well not be. However, a break-though of this kind, introducing such a little change as our not having to speak out loud or having to listen attentively to sounds when communicating, would allow us to share our thoughts efficiently and privately. Moreover, just as thinking distracts us less from our surroundings than listening attentively to sounds originating elsewhere, perhaps one could both communicate and concentrate on one’s surroundings, whether that be driving, or just negotiating our place among other people. It would not be telepathy, the reading of minds, or the invasion of thought, since it would still depend on senders and receivers with the appropriate apparatus being willing to send to, and receive from, one another. We would still have to dial and answer.

Would it come to feel as if one were exchanging thoughts directly? Perhaps. And maybe it would become the preferred way of communicating in public. And odd as this may sound to us, I suspect the experience of taking-in the thoughts of others when reading a manuscript silently was once just as strange to those early Medieval scholars. These are changes in experience that transform our minds, giving us the ability to be (notionally) in two places at once. It is these small changes in how we utilize our minds that may ultimately have the biggest effects on our lives.


Susan Blackmore
Psychologist; Author, Consciousness: An Introduction

ARTIFICIAL, SELF-REPLICATING MEME MACHINES

All around us the techno-memes are proliferating, and gearing up to take control; not that they realise it; they are just selfish replicators doing what selfish replicators do — getting copied whenever and wherever they can, regardless of the consequences. In this case they are using us human meme machines as their first stage copying machinery, until something better comes along. Artificial meme machines are improving all the time, and the step that will change everything is when these machines become self-replicating. Then they will no longer need us. Whether we live or die, or whether the planet is habitable for us or not, will be of no consequence for their further evolution.

I like to think of our planet as one in a million, or one in a trillion, of possible planets where evolution begins. This requires something (a replicator) that can be copied with variation, and selection. As Darwin realised, if more copies are made than can survive, then the survivors will pass on to the next generation of copying whatever helped them get through. This is how all design in the universe comes about.

What is not so often thought about is that one replicator can piggy-back on another by using its vehicles as copying machinery. This has happened here on earth. The first major replicator (the only one for most of earth’s existence and still the most prevalent) is genes. Plants and animals are gene machines — physical vehicles that carry genetic information around, and compete to protect and propagate it. But something happened here on earth that changed everything. One of these gene vehicles, a bipedal ape, became capable of imitation.

Imitation is a kind of copying. The apes copied actions and sounds, and made new variations and combinations of old actions and sounds, and so they let loose a new replicator — memes. After just a few million years the original apes were transformed, gaining enormous brains, dexterous hands, and redesigned throats and chests, to copy more sounds and actions more accurately. They had become meme machines.

We have no idea whether there are any other two-replicator planets out there in the universe because they wouldn’t be able to tell us. What we do know is that our planet is now in the throes of gaining a third replicator — the step that would allow interplanetary communication.

The process began slowly and speeded up, as evolutionary processes tend to do. Marks on clay preserved verbal memes and allowed more people to see and copy them. Printing meant higher copying fidelity and more copies. Railways and roads spread the copies more widely and people all over the planet clamoured for them. Computers increased both the numbers of copies and their fidelity. The way this is usually imagined is a process of human ingenuity creating wonderful technology as tools for human benefit, and with us in control. This is a frighteningly anthropocentric way of thinking about what is happening. Look at it this way:

Printing presses, rail networks, telephones and photocopiers were among early artificial meme machines, but they only carried out one or two of the three steps of the evolutionary algorithm. For example, books store memes and printing presses copy them, but humans still do the varying (i.e. writing the books by combining words in new ways), and the selecting (by choosing which books to buy, to read, or to reprint). Mobile phones store and transmit memes over long distances, but humans still vary and select the memes. Even with the Internet most of the selection is still being done by humans, but this is changing fast. As we old-fashioned, squishy, living meme machines have become overwhelmed with memes we are happily allowing search engines and other software to take over the final process of selection as well.

Have we inadvertently let loose a third replicator that is piggy-backing on human memes? I think we have. The information these machines copy is not human speech or actions; it is digital information competing for space in giant servers and electronic networks, copied by extremely high fidelity electronic processes. I think that once all three processes of copying, varying and selecting are done by these machines then a new replicator has truly arrived. We might call these level-three replicators “temes” (technological-memes) or “tremes” (tertiary memes). Whatever we call them, they and their copying machinery are here now. We thought we were creating clever tools for our own benefit, but in fact we were being used by blind and inevitable evolutionary processes as a stepping stone to the next level of evolution.

When memes coevolved with genes they turned gene machines into meme machines. Temes are now turning us into teme machines. Many people work all day copying and transmitting temes. Human children learn to read very young — a wholly unnatural process that we’ve just got used to — and people are beginning to accept cognitive enhancing drugs, sleep reducing drugs, and even electronic implants to enhance their teme-handling abilities. We go on thinking that we are in control, but looked at from the temes’ point of view we are just willing helpers in their evolution.

So what is the step that will change everything? At the moment temes still need us to build their machines, and to run the power stations, just as genes needed human bodies to copy them and provide their energy. But we humans are fragile, dim, low quality copying machines, and we need a healthy planet with the right climate and the right food to survive. The next step is when the machines we thought we created become self-replicating. This may happen first with nano-technology, or it may evolve from servers and large teme machines being given their own power supplies and the capacity to repair themselves.

Then we would become dispensable. That really would change everything.


Kenneth W. Ford
Retired Physicist & Writer; Coauthor (with John Archibald Wheeler), Geons, Black Holes, and Quantum Foam: A Life in Physics, and Quantum Foam: A Life in Physics

Reading Minds

Not in my lifetime, but someday, somewhere, some team will figure out how to read your thoughts from the signals emitted by your brain. This is not in the same league as human teleportation — theoretically possible, but in truth fictional. Mind reading is, it seems to me, quite likely.

And, as we know from hard disks and flash memories, to be able to read is to be able to write. Thoughts will be implantable.

Some will applaud the development. After all, it will aid the absent minded, enable the mute to communicate, preempt terrorism and crime, and conceivably aid psychiatry. (It will also cut down on texting and provide as reliable a staple for cartoonists as the desert island and the bed.) Some will, quite rightly, deplore it. It will be the ultimate invasion of privacy.

Game-changing indeed. If we choose to play the game. Until about forty years ago, we lived in the "If it is technically feasible, it will happen" era. Now we are in the "If it is technically feasible, we can choose" era. An important moment was the decision in the United States in 1971 not to develop a supersonic transport. An American SST would hardly have been game-changing, but the decision not to build it was a watershed moment in the history of technology. Of course, since then — if I may offer up my own opinions — we should have said no to the International Space Station but didn't, and we should have said yes to the Superconducting Super Collider but didn't. Our skill in choosing needs refinement.

As what is technically feasible proliferates in its complexity, cost, and impact on humankind, we should more often ask the question, "Should we do it?" Take mind reading. We can probably safely assume that the needed device would have to be located close to the brain being read. That would mean that choice is possible. We could let Mind Reader™, Inc. make and market it. Or we could outlaw it. Or we could hold it as an option for special circumstances (much as we now try to do with wiretapping). What we will not have to do is throw up our hands and say, "Since it can be done, it will be done."

I like being able to keep some of my thoughts to myself, and I hope that my descendants will have the same option.


Ernst PÖppel
Neuroscientist, Chairman, Human Science Center and Department of Medical Psychology, Munich University; Author, Mindworks

Future as present. A final experiment

When time came to an end, the gods decided to run a final experiment. They wanted to be prepared after the big crunch for potential trajectories of life after the next big bang. For their experiment they choose two planets in the universe where evolution had resulted in similar developments of life. For planet ONE they decided to interfer with evolution by allowing only ONE species to develop their brain to a high level of complexity. This species referred to itself as being „intelligent“; members of this species were very proud about their achievements in science, technology, the arts or philosophy.

For planet TWO the gods altered just one variable. For this planet they allowed that TWO species with high intelligence would develop. The two species shared the same environment, but — and this was crucial for the divine experiment — they did not communicate directly with each other. Direct communication was limited to their own species only. Thus, one species could not inform directly the other one about future plans; each species could only register what has happened to their common environment.

The question was how life would be managed on planet ONE and on planet TWO. As for any organism, the goal was on both planets to maintain an internal balance or homeostasis by using optimally the available resources. As long as the members of the different samples were not too intelligent stability was maintained. However, when they became more intelligent and according to their own view really smart, and when the frame of judgment changed, i.e. individual interests became dominant, trouble was preprogrammed. Being driven by uncontrolled personal greed, more resources were drawn form the environment than could be replaced. Which planet would do better with such species of too much intelligence to maintain the conditions of life?

Data analysis after the experimental period of 200 years showed that planet TWO did much better to maintain stability of the environment. Why this? The species on planet TWO had to monitor always the consequences of actions of the other species. If one would take too many resources for individual satisfaction, sanctions by the other species would be the consequence. Thus, drawing resources from the environment was controlled by the other species in a bi-directional way resulting in a dynamic equilibrium.

When the gods published their results, they drew the following conclusions: Long-term stability in complex systems like in social systems with members of too much intelligence can be maintained if two complementary systems interact with each other. In case only one system like on planet ONE has been developed it is recommended to adopt for regulative purposes a second system. For social systems it should be the next generation. Their future environment should be made present both conceptually and emotionally. By doing so long-term stabillity is guaranteed.

Being good brain scientists the gods knew that making the future present is not only a matter of abstract or explicit knowledge. This is necessary but not sufficient for action resulting in a long-term equilibrium. Decisions have to be anchored in the emotional systems as well, i.e. an empathic relationship between the members of the two systems has to be developed. If the future becomes present, it can future be a present.



- PAGE 6 -


Charles SEife
Professor of Journalism, New York University; formerly journalist, Science magazine; Author, Zero: The Biography Of A Dangerous Idea

Malthusian Information Famine

For the first time, humans are within reach of a form of immortality. Just a few years ago, we had to be content with archiving a mere handful of events in our lives — storing what we could in a few faded photographs of a day at the zoo, a handful of manuscript pages, a jittery video of an anniversary, or a family legend that gets passed down for three or four generations. All else, all of our memory and knowledge, melts away when we die.

That era is over. It's now within your means to record, in real time, audio and video of your entire existence. A tiny camera and microphone could wirelessly transmit and store everything that you hear and see for the rest of your life. It would take only a few thousand terabytes of hard-drive space to archive a human's entire audiovisual experience from cradle to grave.

Cheap digital memory has already begun to alter our society, at least on a small scale. CDs have become just as quaint as LPs; now, you can carry your entire music collection on a device the size of a credit card. Photographers no longer have to carry bandoliers full of film rolls. Vast databases, once confined to rooms full of spinning magnetic tapes, now wander freely about the world every time a careless government employee misplaces his laptop. Google is busy trying to snaffle up all the world's literature and convert it into a digital format: a task that, astonishingly, now has more legal hurdles than technical ones.

Much more important, though, is that vast amounts of digital memory will change the relationship that humans have with information. For most of our existence, our ability to store and relay knowledge has been very limited. Every time we figured out a better way to preserve and transmit data to our peers and to our descendents — as we moved from oral history to written language to the printing press to the computer age — our civilization took a great leap. Now we are reaching the point where we have the ability to archive every message, every telephone conversation, every communication between human beings anywhere on the planet. For the first time, we as a species have the ability to remember everything that ever happens to us. For millennia, we were starving for information to act as raw material for ideas. Now, we are about to have a surfeit.

Alas, there will be famine in the midst of all that plenty. There are some hundred million blogs, and the number is roughly doubling every year. The vast majority are unreadable. Several hundred billion e-mail messages are sent every day; most of it — current estimates run around 70% — is spam. There seems to be a Malthusian principle at work: information grows exponentially, but useful information grows only linearly. Noise will drown out signal. The moment that we, as a species, finally have the memory to store our every thought, etch our every experience into a digital medium, it will be hard to avoid slipping into a Borgesian nightmare where we are engulfed by our own mental refuse.

We are at the brink of a colossal change: our knowledge is now being limited not only by our ability to gather information and to remember it, but also by our wisdom about when to ignore information — and when to forget.


Gino SegrÈ
Physicist, University of Pennsylvania; Author: Faust In Copenhagen: A Struggle for the Soul of Physics

The Existence of Additional Space-Time Dimensions

Einstein’s Theory of General Relativity, first presented in the fall of 1915, and his earlier Special Theory of Relativity have changed very little of our day to day world, but they have radically altered the way we think about both space and time and have also launched the modern theory of cosmology. If in the near future we discover additional space-time dimensions we will undergo a shift in our perceptions every bit as radical as the one experienced almost a hundred years ago.

Though proof of their existence would necessarily alter our view of the Universe, there is also a way in which our psyches would be changed. I believe we would gain a new confidence that great almost unimaginable phenomena are yet to be discovered. It would also make us realize once again the power that lies in a few simple equations, in the tools we can build to test them and in the human imagination.

At the November 6, 1919 joint meeting of the Royal Society and the Royal Astronomical Society, Sir Frank Watson Dyson reported on the observations of starlight made during the previous May’s solar eclipse. “After a careful study of the plates I am prepared to say that they confirm Einstein’s prediction. A very definite result had been obtained, that light is deflected in accordance with Einstein’s law of gravitation.” Sir John Joseph Thomson, presiding, afterwards called the result “one of the highest achievements of human thought.” It was a triumphant moment for both theoretical physics and observational astronomy.

A few years after the momentous Royal Society meeting a German and a Swedish physicist, Theodor Kaluza and Oskar Klein, reached a striking conclusion. They noticed that the equations of general relativity, when solved in five rather than four dimensions, led to additional solutions that were identical to the well-known Maxwell equations of electromagnetism. Since the apparent fifth dimension had not, and still has not been observed, a necessary additional postulate for this theory to correspond to possible reality was that the fifth dimension was curled up so tightly that any motion in its direction had not been detected.

Einstein, finding this extension of his General Theory of Relativity extraordinarily attractive, tried more than once, without success, to make it part of his lifelong dream of a unified field theory of interactions. But this direction of research fell into relative disfavor during the first post World War II decades during which theoretical physics turned its attention to other matters. It returned with a vengeance during the late 1970s, gaining momentum in the 1980s as physicists began to seriously examine theories that could unite all fundamental interactions into one comprehensive scheme. The rising popularity of superstring theory, mathematically consistent only if additional space-time dimensions are present, has provided the decisive impetus for such considerations.

There are striking differences from the 1915 situation, most particularly the lack of a clear test for the detection of extra dimensions. The novel theories now in fashion do predict that additional particles must be present in nature because of these extensions of space and time, but since the mass of these particles is related to the unknown scale of the extra dimensions, it also remains unknown. Roughly speaking, the smaller the one, the larger the other. Nevertheless the hunt has begun; we are beginning to see in the literature publications from major laboratories with titles such as “ Search for Gamma Rays from the Lightest Kaluza-Klein Particle”, that being the name frequently given to the as of yet undiscovered particles associated with extra dimensions.

These searches are largely motivated by the desire to identify Dark Matter, estimated to be several times more plentiful in our Universe’s makeup than all known species of matter. Kaluza-Klein particles are one possible candidate, perhaps hard to distinguish from other candidates even if found. Challenges abound, but the stakes are very high as well.


Steven Pinker
Johnstone Family Professor, Department of Psychology; Harvard University; Author, The Stuff of Thought

If you Insist: Personal Genomics?

I have little faith in anyone’s ability to predict what will change everything. A look at the futurology of the past turns up many chastening examples of confident predictions of technological revolutions that never happened, such as domed cities, nuclear-powered cars, and meat grown in dishes. By the year 2001, according to the eponymous movie, we were supposed to have suspended animation, missions to Jupiter, and humanlike mainframe computers (though not laptop computers or word processing – the characters used typewriters.) And remember interactive television, the internet refrigerator, and the paperless office?

Technology may change everything, but it’s impossible to predict how. Take another way in which 2001: A Space Odyssey missed the boat. The American women in the film were “girl assistants”: secretaries, receptionists, and flight attendants. As late as 1968, few people foresaw the second feminist revolution that would change everything in the 1970s. It’s not that the revolution didn’t have roots in technological change. Not only did oral contraceptives make it possible for women to time their childbearing, but a slew of earlier technologies (sanitation, mass production, modern medicine, electricity) had reduced the domestic workload, extended the lifespan, and shifted the basis of the economy from brawn to brains, collectively emancipating women from round-the-clock childrearing.

The effects of technology depend not just on what the gadgets do but on billions of people’s judgments of their costs and benefits (do you really want to have call a help line to debug your refrigerator?). They also depend on countless nonlinear network effects, sleeper effects, and other nuisances. The popularity of baby names (Mildred, Deborah, Jennifer, Chloe), and the rates of homicide (down in the 1940s, up in the 1960s, down again in the 1990s) are just two of the social trends that fluctuate wildly in defiance of the best efforts of social scientists to explain them after the fact, let alone predict them beforehand.

But if you insist. This past year saw the introduction of direct-to-consumer genomics. A number of new companies have been recently launched. You can get everything from a complete sequencing of your genome (for a cool $350,000), to a screen of more than a hundred Mendelian disease genes, to a list of traits, disease risks, and ancestry data. Here are some possible outcomes:

• Personalized medicine, in which drugs are prescribed according to the patient’s molecular background rather than by trial and error, and in which prevention and screening recommendations are narrowcasted to those who would most benefit.

• An end to many genetic diseases. Just as Tay-Sachs has almost been wiped out in the decades since Ashkenazi Jews have tested themselves for the gene, a universal carrier screen, combined with preimplantation genetic diagnosis for carrier couples who want biological children, will eliminate a hundred others.

• Universal insurance for health, disability, and home care. Forget the political debates about the socialization of medicine. Cafeteria insurance will no longer be actuarially viable if the highest-risk consumers can load up on generous policies while the low-risk ones get by with the bare minimum.

• An end to the genophobia of many academics and pundits, whose blank-slate doctrines will look increasingly implausible as people learn their about genes that affect their temperament and cognition.

• The ultimate empowerment of medical consumers, who will know their own disease risks and seek commensurate treatment, rather than relying on the hunches and folklore of a paternalistic family doctor.

But then again, maybe not.


LEWIS WOLPERT
Professor of Biology, University College; Author, Six Impossible Things To Do Before Breakfast

COMPUTING THE EMBRYO

We know much about the mechanisms involved in the development of embryos. But given the genome of the egg we cannot predict the way the embryo will develop. This will require a enormous computation in which all the many thousands of components , particularly proteins, are involved and so the behavior of every cell will be known. We would, given a fertilized human egg be able to have a picture of all the details of the newborn baby, including any abnormalities. We would also be able to programme the egg to develop into any shape we desire. The time will come when this is possible.


STEPHON H. ALEXANDER
Assistant Professor of Physics, Penn State

ON BASKETBALL AND SCIENCE CAMPS

I grew up in the northeast Bronx, when in the ‘80’s pretty much everyone’s heroes were basketball sensations Michael Jordan and Dominique Wilkins. Most of my friends, including myself fantasized about playing in the NBA. True, playing basketball was fun. But another obvious incentive was that aside from drug dealers, athletes were the only ones from our socioeconomic background that we saw earning serious money and respect. Despite my early tendencies toward science and math, I also played hooky quite a bit, spending many hours on the P. S. 16 basketball court. There, I would fantasize of one day, making my high school basketball team and doing a 360 dunk. Neither happened. At 15, in the middle of a layup, I stumbled and broke my kneecap, which forced me off the basketball playground for a half a year. I was relegated to homework and consistent class attendance.

Most of my street-court pals didn’t end up graduating from high school. But, although they were far better ball players than I, only one made it to the NBA. A few others did get scouted and ended up playing in big ten basketball teams. To this day, whenever I return to my old neighborhood, I see some of my diploma-less pals doing old school moves with kneepads on.

The year of the broken knee led to a scholarship from a private donor for a summer physics camp for teens called ISI (International Summer Institute). The camp took place in the Southampton, Long Island an environment far different from what I’d ever experienced. Most of the other kids were from foreign countries. I made strange new friends, including Hong, a South Korean boy who spent the summer trying to compute Pi to some decimal point or other. Or the group of young chess players being coached by a Russian chess master. I took college physics. Most of these students went on to become excellent scientists, one of which I am still in touch with. At some point, I met the organizer of the summer camp, a gentleman wearing a leather jacket in summer who turned out to be Nobel Laureate Sheldon Glashow(who coincidentally went to my neighboring High School). He gave us a physics/inspirational talk. During that talk, I realized that there are other types of Michael Jordans, in areas other than basketball and, like Shelly, I could be different plus make a good living as a scientist. More importantly, us teenagers really bonded with each other and, in a sense, formed a young global community of future scientists.

When I returned to the Bronx, I couldn’t really talk much about my experience. After all, a discussion on the Heisenberg principle is far less interesting than ball-park trash talk. I began playing less basketball and eventually went on to college and became a physicist. I could not help feeling a little guilty. In the back of my mind, I knew the real mathematical genius in my neighborhood was a guy named Eric Deabreu. But he never finished high school.

What if there were a global organization of scientists and educators dedicated to identifying (or scouting) the potential Michael Jordans of science, regardless of what part of the world they are from and regardless of socioeconomic background? This is happening on local levels, but not globally. What if these students were provided the resources to reach their full potential and naturally forge a global community of scientific peers and friends? What we would have is, among many benefits, an orchestrated global effort to address the most pressing scientific problems that current and future generations must confront: the energy crisis, global warming, HIV, diplomacy to name a few. I think an inititiative that markets the virtues of science on every corner of the planet, with the same urgency as the basketball scouts on corners of street ball courts, would change the world. Such a reality has long been my vision, which, in light the past efforts of some in the science community, including Clifford Johnson and Jim Gates and Neil Turok, I believe will see come to past.


ROBERT R. PROVINE
Psychologist and Neuroscientist, University of Maryland; Author, Laughter

WHAT CHANGES ANYTHING?

The survival of our ancestors on the savannah depended on their ability to detect change. Change is where the action is. You don't need to know that things are the same, the same, the same.

Our nervous system is biased for the detection of change. Do you feel the watch on your wrist or the ring on your finger? Probably not, unless you have just put them on. You don't see the blind spot of each retina because they are unchanging and filled-in by your brain with information from the visual surround. If the image on your retina is experimentally stabilized, the entire visual field fades in a few seconds and you can see only visual stimuli that move through the field of view. You notice the sound of your home's air control system when it turns-on or turns-off, but not when it's running.

Our perception of changing stimulus amplitude is usually nonlinear. The sensation of loudness grows much more slowly (exponent of 0.6) than the amplitude of the physical stimulus, a reason why rock bands have huge amplifiers and speakers. Perceived brightness grows even more slowly than loudness (exponent of 0.33). The sensation of electric shock grows at an accelerating rate (exponent of 3.5), quickly shifting from a just detectable tingle to an agonizing jolt. Our estimate of length grows linearly (exponent of 1.0); a two-inch line appears twice as long as a one-inch line. We are lousy sound, light, and volt meters, but half-way decent rulers.

We are poor at making absolute judgments of stimulus amplitude, basing decisions on relative, ever changing standards. We judge ourselves to be warm or cool relative to "physiological zero," our adaptation level. The same room can seem either warm or cool, depending on whether you entered it from a chilly basement or an overheated sunroom. The lesson of temperature judgment is applicable to other, more complex measures of change associated with wealth and success. For a highly paid CEO, this year's million dollar bonus does not feel as good as last year's bonus of the same size, the adaptation level. The second term of a presidency does not feel as momentous as the first.

The above exploration of how we perceive changes in anything suggests the difficulty of identifying something that changes everything, from the perspective of the individual. The velocity of change is also critical. Did the Renaissance, Reformation, industrial revolution, or computer revolution, have ordinary people amazed at the changes in their lives? Historical and futuristic speculation about events that change everything features time compression and overestimates the rate of cultural and psychological change. As with previous generations, we may be missing the slow motion revolution that is taking place around us, unaware that we are part of an event that will change everything. What is it?


ALAN ALDA
Actor, writer, director, and host of PBS program "Scientific American Frontiers."

ROUNDING AN ENDLESS VICIOUS CIRCLE

I find it hard to believe that anything will change everything. The only exception might be if we suddenly learned how to live with one another. But, does anyone think that will come about in a foreseeable lifetime?

Evidence from the past seems to point to our becoming increasingly dangerous pretty much every time we come up with a new idea or technology. These new things are usually wholesome and benign at first (movable type, pharmacology, rule of law) but before long we find ways to use these inventions to do what we do best — exercise power over one another.

Even if we were visited by weird little people from another planet and were forced to band together, I doubt if it would be long before we’d be finding ways to break into factions again, identifying those among us who are not quite people.

We keep rounding an endless vicious circle. Will an idea or technology emerge anytime soon that will let us exit this lethal cyclotron before we meet our fate head on and scatter into a million pieces? Will we outsmart our own brilliance before this planet is painted over with yet another layer of people? Maybe, but I doubt it.


GERALD HOLTON
Mallinckrodt Professor of Physics and Professor of the History of Science, Emeritus, at Harvard University; Coeditor, Einstein for the 21st Century: His Legacy in Science, Art, and Modern Culture

DEPLOYMENT OF A SIGNIFICANT ROGUE NUCLEAR DEVICE

An answer can be given once more in one sentence: the intentional, hostile deployment‚ — whether by a state, a terrorist group, or other individuals‚ — of a significant nuclear device.


DAVID DALRYMPLE
Student, MIT's Center for Bits and Atoms; Researcher, Internet 0, Fab Lab Thinner Clients for South Africa, Conformal Computing

ESCAPING THE GRAVITY WELL

Having lived only 17 years so far, to ask what I expect to live to see is to cast a long, wide net.

When looking far into the future, I find it a useful exercise to imagine oneself as a non-human scientist: an alien, a god, or some other creature with a modern understanding of mathematics and physics, but no inherent understanding of human culture or language, beyond what it can deduce from watching what happens at a high level. Essentially, it looks at the world "up to isomorphism": it is not relevant who does what, what it's called, whether it has five fingers or six; but rather how much of it there is, whether it survives, and where it goes.

From this perspective, a few things are apparent: We are depleting our planet's resources faster than they can be replenished. Most of the sun's energy is reflected back into space without being used. There are more of us every minute and we have barely the slightest hint of slowing growth, despite overcrowding and lack of resources. We are trapped in a delicate balance of environmental conditions that has been faltering ever since we began pulling hydrocarbons out of the crust and burning them in the atmosphere (by coincidence, perhaps?), and there seems to be a good chance it will collapse catastrophically in the next 100 years if we don't run out of hydrocarbons first. We have thrown countless small, special-purpose objects into space, and some have transmitted very valuable information back to us. For a short period (while it seemed we would destroy our planet with deliberate nuclear explosions and immediate evacuation might be necessary) we played at shooting living men into the sky, but they have only gone as far as our planet's moon, still within Earth orbit, and sure enough wound up right back in our atmosphere. I should note here that I do not mean any disrespect to the achievements of the Apollo program. In fact, I believe they are among humankind's greatest — so far!

If civilization is to continue expanding, however, as well it shall if it does not collapse, it must escape the tiny gravity well it is trapped in. It is quite unclear to me how this will happen: whether humans will look anything like the humans of today, whether we will escape to sun-orbiting space stations or planetary colonies, but if we expand, we must expand beyond Earth. Even if environmentalists succeed in building a sustainable terrestrial culture around local farming and solar energy, it will only remain sustainable if we limit reproduction, which I expect most of modern society to find unconscionable on some level.

It has always been not only the human way, but the way of all living things, to multiply and colonize new frontiers. What is uniquely human is our potential ability to colonize all frontiers: to adapt our intelligence to new environments, or to adapt environments to suit ourselves. Although the chaos of a planetary atmosphere filled with organic diversity is a beautiful and effective cradle of life, it is no place for the new human-machine civilization. By some means — genetic engineering, medical technology, brain scanning, or something even more fantastical — I expect that humans will gradually shorten the food chain, adapting to use more directly the energy of stars. Perhaps we will genetically modify humans to photosynthesize directly, or implant devices that can provide all the energy for the necessary chemical reactions electrically, or scan our intelligences into solar-powered computing devices. Again, the details are very hard to predict, but I believe there will be some way forward.

I'm getting ahead of myself, so let's come back to the present. There is budding new interest in the development of space technology, in large part undertaken as private ventures, unlike in the past. Many view such operations as absurd luxury vacations for the super-rich, or at best as unlikely schemes to harvest fuel on the Moon and ship it back to Earth via a rail gun. I believe this research is tremendously important, because whatever short-term excuses may be found to fund it, in the long run, it is absolutely critical to the future development of our civilization. I also don't mean to imply that we should give up on environmentalism and sustainability, and just start over with another planet: these principles will only become more important as we spread far and wide, beginning in each new place with even more limited resources and limited contact with home. Not to mention that if Earth can be saved, it would be a tremendous cultural treasure to preserve as long as possible.

I'm not as optimistic about interstellar travel as some (I certainly don't expect it to become practical in this century), but I'm also much more optimistic about the ability of human civilization to adapt and survive without the precise conditions that were necessary for its evolution. There are so many possible solutions for the survival of humans (or posthumans) in solar orbit or on "inhospitable" planets that I expect we will find some way to make it work long before generational or faster-than-light voyages to faraway star systems; in fact, I expect it in my lifetime. But someday, "escaping the gravity well" will mean not that of Earth, but that of our star, and then humankind's ship will at last have...gone out.


KEITH DEVLIN
Mathematician; Executive Director, Center for the Study of Language and Information, Stanford; Author, The Unfinished Game

THE MOBILE PHONE

This is a tough one. Not because there is a shortage of possibilities for major advances in science, and not because any predictions Edgies make are likely to be way off the mark (history tells us that they assuredly will); rather you set the hurdle impossibly high with "change everything." and "expect to live to see". The contraceptive pill "changed everything" for people living in parts of the world where it is available and the Internet "changed everything" for those of us who are connected. But for large parts of the world those advances may as well not have occurred. Moreover, many scientific changes take a generation or more to have a significant effect.

But since you ask, I'll give you an answer, and it's one I am pretty sure will happen in my lifetime (say, thirty more years). The reason for my confidence? The key scientific and technological steps have already been taken. In giving my answer, I'm adopting a somewhat lawyer-like strategy of taking advantage of that word "development" in your question. Scientific advances do not take place purely in the laboratory, particularly game-changing ones. They have to find their way into society as a whole, and that transition is an integral part of any "scientific advance."

History tells us that it can often take some time for a scientific or technological advance to truly "change everything". Understanding germs and diseases, electricity, the light bulb, and the internal combustion engine are classic examples. (Even these examples still have not affected everyone on the planet, of course, at least not directly, but that is surely just a matter of time.) The development I am going to focus on is the final one in the scientific chain that brings the results of the science into everyday use.

My answer? It's staring us in the face. The mobile phone. Within my lifetime I fully expect almost every living human adult, and most children, in the world to own one. (Neither the pen nor the typewriter came even close to that level of adoption, nor did the automobile.) That puts global connectivity, immense computational power, and access to all the world's knowledge amassed over many centuries, in everyone's hands. The world has never, ever, been in that situation before. It really will change everything. From the way individual people live their lives, to the way wealth and power are spread across the globe. It is the ultimate democratizing technology. And if my answer seems less "cutting edge" or scientifically sexy than many of the others you receive, I think that just shows how dramatic and pervasive the change has already been.

What other object do you habitually carry around with you and use all the time, and take for granted? Yet when did you acquire your first mobile phone? Can you think of a reason why anyone else in the world will not react the same way when the technology reaches them? Now imagine the impact on someone in apart of the world that has not had telephones, computers, the Internet, or even easy access to libraries. I'll let your own answers to these questions support my case that this is game changing on a hitherto unknown global scale.



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FRANK J. TIPLER
Professor of Mathematical Physics, Tulane University; Author, The Physics of Christianity

BUT WE SHALL ALL BE CHANGED

I'm 62, so I'll have to limit my projections to what I expect to happen in the next two to three decades. I believe these will be the most interesting times in human history (Remember the old Chinese curse about "interesting times?") Humanity will see, before I die, the "Singularity," the day when we finally create a human level artificial intelligence. This involves considering the physics advances that will be required to create the computer that is capable of running a strong AI program.

Although by both my calculations and those of Ray Kurzweil (originator of the "Singularity" idea), the 10 teraflop speed of today's supercomputers have more than enough computing power to run a minimum AI program, we are missing some crucial idea in this program. Conway's Game of Life has been proven to be a universal program, capable of expressing a strong AI program, and it should therefore be capable, if allowed to run long enough, of bootstrapping itself into the complexity of human level intelligence. But Game of Life programs do no do so. They increase their complexity just so far, and then stop. Why, we don't know. As I said, we are missing something, and what we are missing is the key to human creativity.

But an AI program can be generated by brute force. We can map an entire human personality, together with a simulated environment into a program, and run this. Such a program would be roughly equivalent to the program being run in the movie The Matrix, and it would require enormous computing power, power far beyond today's supercomputers. The power required can only be provided by a quantum computer.

A quantum computer works by parallel processing across the multiverse. That is, part of the computation is done in this universe by you and your part of the quantum computer, and the other parts of the computation are done by your analogues with their parts of the computer in the other universes of the multiverse. The full potential of the quantum computer has not been realized because the existence of the multiverse has not yet been accepted, even by workers in the field of quantum computation, in spite of the fact that the multiverse's existence is required by quantum mechanics, and by classical mechanics in its most powerful form, Hamilton-Jacobi theory.

Other new technologies become possible via action across the multiverse. For example, the Standard Model of particle physics, the theory of all forces and particles except gravity, a theory confirmed by many experiments done over the past forty years, tells us that it is possible to transcend the laws of conservation of baryon number (number of protons plus neutrons) and conservation of lepton number (number of electrons plus neutrinos) and thereby convert matter into energy in a process far more efficient that nuclear fission or fusion. According to the Standard Model, the proton and electron making up a hydrogen atom can be combined to yield pure energy in the form of photons, or neutrino-anti-neutrino pairs. If the former, then we would have a mechanism that would allow us to convert garbage into energy, a device Doc in the movie Back to the Future obtained from his trip to the future. If the latter, then the directed neutrino-anti-neutrino beam would provide the ultimate rocket: the exhaust would be completely invisible to those nearby, just as the propulsion mechanism that Doc also obtained from the future. The movie writers got it right, Doc's future devices are indeed in our future.

Quantum computer running an AI program, direct conversion of matter into energy, the ultimate rocket that would allow the AI's and the human downloads to begin interstellar travel at near light speed, depend on the same physics, and should appear at the same time in the future.

Provided we have the courage to develop the technology allowed by the known laws of physics. I have grave doubts that we will.

In order to have advances in physics and engineering, one must first have physicists and engineers. The number of students majoring in these subjects has dropped enormously in the quarter century that I have been a professor. Worse, the quality of the few students we do have has dropped precipitously. The next decade will see the retirement of Stephen Hawking, and others less well-known but of similar ability, but I know of no one of remotely equal creativity to replace them. Small wonder, given that the starting salary of a Wall Street lawyer fresh out of school is currently three times my own physicist's salary. As a result, most American engineers and physicists are now foreign born.

But can foreign countries continue to supply engineers and physicists? That is, will engineers and physicists be available in any country? The birth rate of the vast majority of the developed nations has been far below replacement level for a decade and more. This birth dearth also holds for China, due to their one-child policy, and remarkably is developing even in the Muslim and southern nations. We may not have enough people in the next twenty years to sustain the technology we already have, to say nothing of developing the technology allowed by the known laws of physics that I describe above.

The great Galileo scholar Giorgio de Santillana, who taught me history of science when I was an undergraduate at MIT in the late 1960's, wrote that Greek scientific development ended in the century or so before the Christian era because of a birth dearth and a simultaneous bureaucratization of intellectual inquiry. I fear we are seeing a repeat of this historical catastrophe today.

However, I remain cautiously optimistic that we will develop the ultimate technology described above, and transfer it with faltering hands to our ultimate successors, the AI's and the human downloads, who will be thus enabled to expand outward into interstellar space, engulf the universe, and live forever.


TERRENCE SEJNOWSKI
Computational Neuroscientist, Salk Institute, Coauthor, The Computational Brain

COMPUTERS ARE THE NEW MICROSCOPES

Scientific ideas change when new instruments are developed that detect something new about nature. Electron microscopes, radio telescopes, and patch recordings from single ion channels have all led to game-changing discoveries.

We are in the midst of a technological revolution in computing that has been unfolding since 1950 and is having a profound impact on all areas of science and technology. As computing power doubles every 18 months according to Moore's Law, unprecedented levels of data collection, storage and analysis have revolutionized many areas of science.

For example, optical microscopy is undergoing a renaissance as computers have made it possible to localize single molecules with nanometer precision and image the extraordinary complex molecular organization inside cells. This has become possible because computers allow beams to be formed and photons collected over long stretches of time, perfectly preserved and processed into synthetic pictures. High resolution movies are revealing the dynamics of macromolecular structures and molecular interactions for the first time.

In trying to understand brain function we have until recently relied on microelectrode technology that limited us to recording from one neuron at a time. Coupled with advances in molecular labels and reporters, new two-photon microscopes guided by computers will soon make it possible to image the electrical activity and chemical reactions occurring inside millions of neurons simultaneously. This will realize Sherrington's dream of seeing brain activity as an "enchanted loom where millions of flashing shuttles weave a dissolving pattern, always a meaningful pattern though never an abiding one; a shifting harmony of subpatterns."

By 2015 computer power will begin to approach the neural computation that occurs in brains. This does not mean we will be able to understand it, only that we can begin to approach the complexity of a brain on its own terms. Coupled with advances in large-scale recordings from neurons we should by then be in a position to crack many of the brain's mysteries, such as how we learn and where memories reside. However, I would not expect a computer model of human level intelligence to emerge from these studies without other breakthroughs that cannot be predicted.

Computers have become the new microscopes, allowing us to see behind the curtains. Without computers none of this would be possible, at least not in my lifetime.


HELEN FISHER
Research Professor, Department of Anthropology, Rutgers University; Author, Why We Love

HIDDEN PERSUADERS '09

"Mind is primarily a verb," wrote philosopher John Dewey. Every time we do or think or feel anything the brain is doing something. But what? And can we use what scientists are learning about these neural gymnastics to get what we want? I think we can and we will, in my life time, due to some mind — bending developments in contemporary neuroscience. Brain scanning; genetic studies; antidepressant drug use; estrogen replacement therapy; testosterone patches; L-dopa and newer drugs to prevent or retard brain diseases; recreational drugs; sex change patients; gene doping by athletes: all these and other developments are giving us data on how the mind works — and opening new avenues to use brain chemistry to change who we are and what we want. As the field of epigenetics takes on speed, we are also beginning to understand how the environment affects brain systems, even turns genes on and off — further enabling us (and others) to adjust brain chemistry, affecting who we are, how we feel and what we think we need.

But is this new? Our forebears have been manipulating brain chemistry for millions of years. Take "hooking up," the current version of the "one night stand," one of humankind's oldest forms of chemical persuasion. During sex, stimulation of the genitals escalates activity in the dopamine system, the neurotransmitter network that my colleagues and I have found to be associated with feelings of romantic love. And with orgasm you experience a flood of oxytocin and vasopressin, neurochemicals associated with feelings of attachment. Casual sex isn't always casual. And I suspect our ancestors seduced their peers to (unconsciously) alter their brain chemistry, thereby nudging "him" or "her" toward feelings of passion and/or attachment. Indeed, this chemical persuasion works. In a recent study of 507 college students, anthropologist Justin Garcia found that 50% of women and 52% of men hopped into bed with an acquaintance or a stranger in hopes of starting a longer relationship. And about one third of these hook ups turned into romance.

In 1957 Vance Packard wrote The Hidden Persuaders to unmask the subtle psychological techniques that advertisers use to manipulate people's feelings and induce them to buy. We have long been using psychology to persuade other's minds. But now we are learning why our psychological strategies work. Holding hands, for example, generates feelings of trust, in part, because it triggers oxytocin activity. As you see another person laugh, you naturally mimic him or her, moving muscles in your face that trigger nerves to alter your neurochemistry so that you feel happy too. That's one reason why we feel good when we are around happy people. "Mirror neurons" also enable us to feel what another feels. Novelty drives up dopamine activity to make you more susceptible to romantic love. The placebo effect is real. And wet kissing transfers testosterone in the saliva, helping to stimulate lust.

The black box of our humanity, the brain, is inching open. And as we peer inside for the first time in human time, you and I will hold the biological codes that direct our deepest wants and feelings. We have begun to use these codes too. I, for example, often tell people that if they want to ignite or sustain feelings of romantic love in a relationship, they should do novel and exciting things together — to trigger or sustain dopamine activity. Some 100 million prescriptions for antidepressants are written annually in the United States. And daily many alter who we are in other chemical ways. As scientists learn more about the chemistry of trust, empathy, forgiveness, generosity, disgust, calm, love, belief, wanting and myriad other complex emotions, motivations and cognitions, even more of us will begin to use this new arsenal of weapons to manipulate ourselves and others. And as more people around the world use these hidden persuaders, one by one we may subtly change everything.


LERA BORODITSKY
Assistant Professor of Psychology, Neuroscience, and Symbolic Systems, Stanford University

KNOWLEDGE ABOUT HOW WE KNOW WILL CHANGE EVERYTHING

There is an old joke about a physicist, a biologist, and an epistemologist being asked to name the most impressive invention or scientific advance of modern times. The physicist does not hesitate — "It is quantum theory. It has completely transformed the way we understand matter." The biologist says "No. It is the discovery of DNA — it has completely transformed the way we understand life." The epistemologist looks at them both and says "I think it's the thermos." The thermos? Why on earth the thermos? "Well," the epistemologist explains patiently, "If you put something cold in it, it will keep it cold. And if you put something hot in it, it will keep it hot." Yeah, so what?, everyone asks. "Aha!" the epistemologist raises a triumphant finger "How does it know?"

With this in mind, it may seem foolhardy to claim that epistemology will change the world. And yet, that is precisely what I intend to do here. I think that knowledge about how we know will change everything. By understanding the mechanisms of how humans create knowledge, we will be able to break through normal human cognitive limitations and think the previously unthinkable.

The reason the change is happening now is that modern Cognitive Science has taken the role of empirical epistemology. The empirical approach to the origins of knowledge is bringing about breathtaking breakthroughs and turning what once were age-old philosophical mysteries into mere scientific puzzles.

Let me give you an example. One of the great mysteries of the mind is how we are able to think about things we can never see or touch. How do we come to represent and reason about abstract domains like time, justice, or ideas? All of our experience with the world is physical, accomplished through sensory perception and motor action. Our eyes collect photons reflected by surfaces in the world, our ears receive air-vibrations created by physical objects, our noses and tongues collect molecules, and our skin responds to physical pressure. In turn, we are able to exert physical action on the world through motor responses, bending our knees and flexing our toes in just the right amount to defy gravity. And yet our internal mental lives go far beyond those things observable through physical experience; we invent sophisticated notions of number and time, we theorize about atoms and invisible forces, and we worry about love, justice, ideas, goals, and principles. So, how is it possible for the simple building blocks of perception and action to give rise to our ability to reason about domains like mathematics, time, justice, or ideas?

Previous approaches to this question have vexed scholars. Plato, for example, concluded that we cannot learn these things, and so we must instead recollect them from past incarnations of our souls. As silly as this answer may seem, it was the best we could do for several thousand years. And even some of our most elegant and modern theories (e.g., Chomskyan linguistics) have been awkwardly forced to conclude that highly improbable modern concepts like ‘carburetor' and ‘bureaucrat' must be coded into our genes (a small step forward from past incarnations of our souls).

But in the past ten years, research in cognitive science has started uncovering the neural and psychological substrates of abstract thought, tracing the acquisition and consolidation of information from motor movements to abstract notions like mathematics and time. These studies have discovered that human cognition, even in its most abstract and sophisticated form, is deeply embodied, deeply dependent on the processes and representations underlying perception and motor action. We invent all kinds of complex abstract ideas, but we have to do it with old hardware: machinery that evolved for moving around, eating, and mating, not for playing chess, composing symphonies, inventing particle colliders, or engaging in epistemology for that matter. Being able to re-use this old machinery for new purposes has allowed us to build tremendously rich knowledge repertoires. But it also means that the evolutionary adaptations made for basic perception and motor action have inadvertently shaped and constrained even our most sophisticated mental efforts. Understanding how our evolved machinery both helps and constrains us in creating knowledge, will allow us to create new knowledge, either by using our old mental machinery in yet new ways, or by using new and different machinery for knowledge-making, augmenting our normal cognition.

So why will knowing more about how we know change everything? Because everything in our world is based on knowledge. Humans, leaps and bounds beyond any other creatures, acquire, create, share, and pass on vast quantities of knowledge. All scientific advances, inventions, and discoveries are acts of knowledge creation. We owe civilization, culture, science, art, and technology all to our ability to acquire and create knowledge. When we study the mechanics of knowledge building, we are approaching an understanding of what it means to be human — the very nature of the human essence. Understanding the building blocks and the limitations of the normal human knowledge building mechanisms will allow us to get beyond them. And what lies beyond is, well, yet unknown...


TOR NØRRETRANDERS
Science Writer; Consultant; Lecturer, Copenhagen; Author, The Generous Man

INSIDE OUT: THE EPISTEMOLOGY OF EVERYTHING

Understanding that the outside world is really inside us and the inside world is really outside us will change everything. Both inside and outside. Why?

"There is no out there out there", physicist John Wheeler said in his attempt to explain quantum physics. All we know is how we correlate with the world. We do not really know what the world is really like, uncorrelated with us. When we seem to experience an external world that is out there, independent of us, it is something we dream up.

Modern neurobiology has reached the exact same conclusion. The visual world, what we see, is an illusion, but then a very sophisticated one. There are no colours, no tones, no constancy in the "real" world, it is all something we make up. We do so for good reasons and with great survival value. Because colors, tones and constancy are expressions of how we correlate with the world.

The merging of the epistemological lesson from quantum mechanics with the epistemological lesson from neurobiology attest to a very simple fact: What we percieve as being outside of us is indeed a fancy and elegant projection of what we have inside. We do make this projection as as result of interacting with something not inside, but everything we experience is inside.

Is it not real? It embodies a correlation that is very real. As physicist N. David Mermin has argued, we do have correlations, but we do not know what it is that correlates, or if any correlata exists at all. It is a modern formulation of quantum pioneer Niels Bohr's view: "Physics is not about nature, it is about what we can say about nature."

So what is real, then? Inside us humans a lot of relational emotions exists. We feel affection, awe, warmth, glow, mania, belonging and refusal towards other humans and to the world as a whole. We relate and it provokes deep inner emotional states. These are real and true, inside our bodies and percieved not as "real states" of the outside world, but more like a kind of weather phenomena inside us.

That raises the simple question: Where do these internal states come from? Are they an effect of us? Did we make them or did they make us? Love exists before us (most of us were conceived in an act of love). Friendship, family bonds, hate, anger, trust, distrust, all of these entities exist before the individual. They are primary. The illusion of the ego denies the fact that they are there before the ego consciously decided to love or hate or care or not. But the inner states predate the conscious ego. And they predate the bodily individual.

The emotional states inside us are very, very real and the product of biological evolution. They are helpful to us in our attempt to survive. Experimental economics and behavioral sciences have recently shown us how important they are to us as social creatures: To cooperate you have to trust the other party, even though a rational analysis will tell you that both the likelihood and the cost of being cheated is very high. When you trust, you experience a physiologically detectable inner glow of pleasure. So the inner emotional state says yes. However, if you rationally consider the objects in the outside world, the other parties, and consider their trade-offs and motives, you ought to choose not to cooperate. Analyzing the outside world makes you say no. Human cooperation is dependent on our giving weight to what we experience as the inner world compared to what we experience as the outer world.

Traditionally, the culture of science has denied the relevance of the inner states. Now, they become increasingly important to understanding humans. And highly relevant when we want to build artefacts that mimic us.

Soon we will be building not only Artificial Intelligence. We will be building Artificial Will. Systems with an ability to convert internal decisions and values into external change. They will be able to decide that they want to change the world. A plan inside becomes an action on the outside. So they will have to know what is inside and outside.

In building these machines we ourselves will learn something that will change everything: The trick of perception is the trick of mistaking an inner world for the outside world. The emotions inside are the evolutionary reality. The things we see and hear outside are just elegant ways of imagining correlata that can explain our emotions, our correlations. We don't hear the croak, we hear the frog.

When we understand that the inner emotional states are more real than what we experience as the outside world, cooperation becomes easier. The epoch of insane mania for rational control will be over.

What really changes is they way we see things, the way we experience everything. For anything to change out there you have to change everything in here. That is the epistemological situation. All spiritual traditions have been talking about it. But now it grows from the epistemology of quantum physics, neurobiology and the building of robots.

We will be sitting there, building those Artificial Will-robots. Suddenly we will start laughing. There is no out there out there. It is in here. There is no in here in here. It is out there. The outside is in here. Who is there?

That laughter will change everything.


EMANUEL DERMAN
Professor, Financial Engineering, Columbia University; Principal, Prisma Capital Partners; Former Head, Quantitative Strategies Group, Equities Division, Goldman Sachs & Co.; Author, My Life as a Quant

NO MORE TIME DECAY

The biggest game-changer looming in your future, if not mine, is Life Prolongation. It works for mice and worms, and surely one of these days it'll work for the rest of us.

The current price for Life Prolongation seems to be semi-starvation; the people who try it wear loose clothes to hide their ribs and intentions. There's something desperate and shameful about starving yourself in order to live longer. But right now biologists are tinkering with reservatrol and sirtuins, trying to get you the benefit of life prolongation without cutting back on calories.

Life and love gets their edge from the possibility of their ending. What will life be like when we live forever? Nothing will be the same.

The study of financial options shows that there is no free lunch. What you lose on the swings you gain on the roundabouts. If you want optionality, you have to pay a price, and part of that price is that the value of your option erodes every day. That's time decay. If you want a world where nothing fades away with time anymore, it will be because because there's nothing to fade away.

No one dies. No one gets older. No one gets sick. You can't tell how old someone is by looking at them or touching them. No May-September romances. No room for new people. Everyone's an American car in Havana, endlessly repaired and maintained long after its original manufacturer is defunct. No breeding. No one born. No more evolution. No sex. No need to hurry. No need to console anyone. If you want something done, give it to a busy man, but no one need be busy when you have forever. Life without death changes absolutely everything.

If everyone is an extended LP, the turntable has to turn very slowly.

Who's going to do the real work, then? Chosen people who will volunteer or be volunteered to be mortal.

If you want things to stay the same, then things will have to change (Giuseppe di Lampedusa in The Leopard).


GREGORY COCHRAN
Consultant, Adaptive Optics; Adjunct Professor of Anthropology, University of Utah; Coauthor, The 10,000 Year Explosion

BETTER MEASUREMENTS

Our most reliable engine of change has been increased understanding of the physical world. First it was Galilean dynamics and Newtonian gravity, then electromagnetism, later quantum mechanics and relativity. In each case, new observations revealed new physics, physics that went beyond the standard models — physics that led to new technologies and to new ways of looking at the universe. Often those advances were the result of new measurement techniques. The Greeks never found artificial ways of extending their senses, which hobbled their protoscience. But ever since Tycho Brahe, a man with a nose for instrumentation, better measurements have played a key role in Western science.

We can expect significantly improved observations in many areas over the next decade. Some of that is due to sophisticated, expensive, and downright awesome new machines. The Large Hadron Collider should begin producing data next year, and maybe even information. We can scan the heavens for the results of natural experiments that you wouldn't want to try in your backward — events that shatter suns and devour galaxies — and we're getting better at that. That means devices like the 30-meter telescope under development by a Caltech-led consortium, or the 100-meter OWL (Overwhelmingly Large Telescope) under consideration by the European Southern Observatory. Those telescopes will actively correct for the atmospheric fluctuations which make stars twinkle — but that's almost mundane, considering that we have a neutrino telescope at the bottom of the Mediterranean and another buried deep in the Antarctic ice. We have the world's first real gravitational telescope (LIGO, the Laser Interferometer Gravitational-Wave Observatory) running now, and planned improvements should increase its sensitivity enough to study cosmic fender-benders in the neighborhood, as (for example) when two black holes collide. An underground telescope, of course….

There's no iron rule ensuring that revolutionary discoveries must cost an arm and a leg: ingenious experimentalists are testing quantum mechanics and gravity in table-top experiments, as well. They'll find surprises. When you think about it, even historians and archaeologists have a chance of shaking gold out of the physics-tree: we know the exact date of the Crab Nebula supernova from old Chinese records, and with a little luck we'll find some cuneiform tablets that give us some other astrophysical clue, as well as the real story about the battle of Kadesh…

We have a lot of all-too-theoretical physics underway, but there's a widespread suspicion that the key shortage is data, not mathematics. The universe may not be stranger than we can imagine but it's entirely possible that it's stranger than we have imagined thus far. We have string theory, but what Bikini test has it brought us? Experiments led the way in the past and they will lead the way again.

We will probably discover new physics in the next generation, and there's a good chance that the world will, as a consequence, become unimaginably different. For better or worse.


HOWARD RHEINGOLD
Communications Expert; Author, Smart Mobs

SOCIAL MEDIA LITERACY

Social media literacy is going to change many games in unforeseeable ways. Since the advent of the telegraph, the infrastructure for global, ubiquitous, broadband communication media have been laid down, and of course the great power of the Internet is the democracy of access — in a couple of decades, the number of users has grown from a thousand to a billion. But the next important breakthroughs won't be in hardware or software but in know-how, just the most important after-effects of the printing press were not in improved printing technologies but in widespread literacy. The Gutenberg press itself was not enough. Mechanical printing had been invented in Korea and China centuries before the European invention. For a number of reasons, a market for print and the knowledge of how to use the alphabetic code for transmitting knowledge across time and space broke out of the scribal elite that had controlled it for millennia. From around 20,000 books written by hand in Gutenberg's lifetime, the number of books grew to tens of millions within decades of the invention of moveable type. And the rapidly expanding literate population in Europe began to create science, democracy, and the foundations of the industrial revolution. Today, we´re seeing the beginnings of scientific, medical, political, and social revolutions, from the instant epidemiology that broke out online when SARS became known to the world, to the use of social media by political campaigns. But we´re only in the earliest years of social media literacy. Whether universal access to many-to-many media will lead to explosive scientific and social change depends more on know-how now than physical infrastructure. Would the early religious petitioners during the English Civil War, and the printers who eagerly fed their need to spread their ideas have been able to predict that within a few generations, monarchs would be replaced by constitutions? Would Bacon and Newton have dreamed that entire populations, and not just a few privileged geniuses, would aggregate knowledge and turn it into technology? Would those of us who used slow modems to transmit black and white text on the early Internet 15 years ago been able to foresee YouTube?


BRIAN KNUTSON
Associate Professor of Psychology and Neuroscience; Stanford University

NEUROPHENOMICS + TARGETED STIMULATION = PSYCHOLOGICAL OPTIMIZATION?

The fashionable phrase "game-changing" can imply not only winning a game (usually with a dramatic turnaround), but also changing the rules of the game. If we could change the rules of the mind, we would alter our perception of the world, which would change everything (at least for humans). Assuming that the brain is the organ of the mind, what are the brain's rules, and how might we transcend them? Technological developments that combine neurophenomics with targeted stimulation will offer answers within the next century.

In contrast to genomics, less talk (and funding) has been directed towards phenomics. Yet, phenomics is the logical endpoint of genomics (and a potential bottleneck for clinical applications). Phenomics has traditionally focused on a broad range of individual characteristics including morphology, biochemistry, physiology, and behavior. "Neurophenomics," however, might more specifically focus on patterns of brain activity that generate behavior. Advances in brain imaging techniques over the past two decades now allow scientists to visualize changes in the activity of deep-seated brain regions at a spatial resolution of less than a millimeter and a temporal resolution of less than a second. These technological breakthroughs have sparked an interdisciplinary revolution that will culminate in the mapping of a "neurophenome." The neural patterns of activity that make up the neurophenome may have genetic and epigenetic underpinnings, but can also respond dynamically to environmental contingencies. The neurophenome should link more closely than behavior to the genome, could have one-to-many or many-to-one mappings to behavior, and might ideally explain why groups of genes and behaviors tend to travel together. Although mapping the neurophenome might sound like a hopelessly complex scientific challenge, emerging research has begun to reveal a number of neural signatures that reliably index not only the obvious starting targets of sensory input and motor output, but also more abstract mental constructs like anticipation of gain, anticipation of loss, self-reflection, conflict between choices, impulse inhibition, and memory storage / retrieval (to name but a few...). By triangulating across different brain imaging modalities, the neurophenome will eventually point us towards spatially, temporally, and chemically specific targets for stimulation.

Targeted neural stimulation has been possible for decades, starting with electrical methods, and followed by chemical methods. Unfortunately, delivery of any signal to deep brain regions is usually invasive (e.g., requiring drilling holes in the skull and implanting wires or worse), unspecific (e.g., requiring infusion of neutoransmitter over minutes to distributed regions), and often transient (e.g., target structures die or protective structures coat foreign probes). Fortunately, better methods are on the horizon. In addition to developing ever smaller and more temporally precise electrical and chemical delivery devices, scientists can now nearly instantaneously increase or decrease the firing of specific neurons with light probes that activate photosensitive ion channels. As with the electrical and chemical probes, these light probes can be inserted into the brains of living animals and change ongoing behavior. But at present, scientists still have to insert invasive probes into the brain. What if one could deliver the same spatially and temporally targeted bolus of electricity, chemistry, or even light to a specific brain location without opening the skull? Such technology does not yet exist — but given the creativity, brilliance, and pace of recent scientific advances, I expect that relevant tools will emerge in the next decade (e.g., imagine the market for "triangulation helmets"...). Targeted and hopefully noninvasive stimulation, combined with the map that comprises the neurophenome, will revolutionize our ability to control our minds.

Clinical implications of this type of control are straightforward, yet startling. Both psychotherapy and pharmacotherapy look like blunt instruments by comparison. Imagine giving doctors or even patients the ability to precisely and dynamically control the firing of acetylcholine neurons in the case of dementia, dopamine neurons in the case of Parkinson's disease, or serotonin neurons in the case of unipolar depression (and so on...). These technological developments will not only improve clinical treatment, but will also advance scientific theory. Along with applications designed to cure will come demands for applications that aim to enhance. What if we could precisely but noninvasively modulate mood, alertness, memory, control, willpower, and more? Of course, everyone wants to win the brain game. But are we ready for the rules to change?


ERIC DREXLER
Researcher; Policy Advocate; Author, Engines of Creation

KNOWLEDGE SPREADING

Human knowledge changes the world as it spreads, and the spread of knowledge can be observed. This makes some change predictable. I see great change flowing from the spread of knowledge of two scientific facts: one simple and obvious, the other complex and tangled in myth. Both are crucial to understanding the climate change problem and what we can do about it.

First, the simple scientific fact: Carbon stays in the atmosphere for a long time.

To many readers, this is nothing new, yet most who know this make a simple mistake. They think of carbon as if it were sulfur, with pollution levels that rise and fall with the rate of emission: Cap sulfur emissions, and pollution levels stabilize; cut emissions in half, cut the problem in half. But carbon is different. It stays aloft for about a century, practically forever. It accumulates. Cap the rate of emissions, and the levels keep rising; cut emissions in half, and levels will still keep rising. Even deep cuts won't reduce the problem, but only the rate of growth of the problem.

In the bland words of the Intergovernmental Panel on Climate Change, "only in the case of essentially complete elimination of emissions can the atmospheric concentration of CO2 ultimately be stabilised at a constant [far higher!] level." This heroic feat would require new technologies and the replacement of today's installed infrastructure for power generation, transportation, and manufacturing. This seems impossible. In the real world, Asia is industrializing, most new power plants burn coal, and emissions are accelerating, increasing the rate of increase of the problem.

The second fact (complex and tangled in myth) is that this seemingly impossible problem has a correctable cause: The human race is bad at making things, but physics tells us that we can do much better.

This will require new methods for manufacturing, methods that work with the molecular building blocks of the stuff that makes up our world. In outline (says physics-based analysis) nanoscale factory machinery operating on well-understood principles could be used to convert simple chemical compounds into beyond-state-of-the-art products, and do this quickly, cleanly, inexpensively, and with a modest energy cost. If we were better at making things, we could make those machines, and with them we could make the products that would replace the infrastructure that is causing the accelerating and seemingly irreversible problem of climate change.

What sorts of products? Returning to power generation, transportation, and manufacturing, picture roads resurfaced with solar cells (a tough, black film), cars that run on recyclable fuel (sleek, light, and efficient), and car-factories that fit in a garage. We could make these easily, in quantity, if we were good at making things.

Developing the required molecular manufacturing capabilities will require hard but rewarding work on a global scale, converting scientific knowledge into engineering practice to make tools that we can use to make better tools. The aim that physics suggests is a factory technology with machines that assemble large products from parts made of smaller parts (made of smaller parts, and so on) with molecules as the smallest parts, and the smallest machines only a hundred times their size.

The basic science to support this undertaking flourishing, but the engineering has has gotten a slow start, and for a peculiar reason: The idea of using tiny machines to make things has been burdened by an overgrowth of mythology. According to fiction and pop culture, it seems that all tiny machines are robots made of diamond, and they're dangerous magic — smart and able to do almost anything for us, but apt to swarm and multiply and maybe eat everything, probably including your socks.

In the real world, manufacturing does indeed use "robots", but these are immobile machines that work in an assembly line, putting part A in slot B, again and again. They don't eat, they don't get pregnant, and making them smaller wouldn't make them any smarter.

There is a mythology in science, too, but of a more sober sort, not a belief in glittery nanobugs, but a skepticism rooted in mundane misconceptions about whether nanoscale friction and thermal motion will sabotage nanomachines, and whether there are practical steps to take in laboratories today. (No, and yes.) This mythology, by the way, seems regional and generational; I haven't encountered it in Japan, India, Korea, or China, and it is rare among the rising generation of researchers in the U.S.

The U.S. National Academies has issued a report on molecular manufacturing, and it calls for funding experimental research. A roadmap prepared by Battelle with several U.S. National Laboratories has studied paths forward, and suggests research directions. This knowledge will spread, and will change the game.

I should add one more fact about molecular manufacturing and the climate change problem: If we were good at making things, we could make efficient devices able to collect, compress, and store carbon dioxide from the atmosphere, and we could make solar arrays large enough to generate enough power to do this on a scale that matters. A solar array area, that if aggregated, would fit in a corner of Texas, could generate 3 terawatts. In the course of 10 years, 3 terawatts would provide enough energy remove all the excess carbon the human race has added to the atmosphere since the Industrial Revolution began. So far as carbon emissions are concerned, this would fix the problem.



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NICHOLAS A. CHRISTAKIS
Physician and social scientist, Harvard

THE ANTHROPOSPHERE

We will create life from inanimate compounds, and we will find life on Mars or in space. But the life that more immediately interests me lies between these extremes, in the middle range we all inhabit between our genes and our stars. It is the thin bleeding line within the thin blue line, the anthroposphere within the biosphere. It is us.

And we are rapidly and inexorably changing. I do not mean that our numbers are exploding — a topic that has been attracting attention since Malthus. I mean a very modern and massive set of changes in the composition of the human population.

The global population stood at one million at 10,000 BC, 50 million at 1,000 BC, and 310 million in 1,000 AD. It stood at about one billion in 1800, 1.65 billion in 1900, and 6.0 billion in 2000. Analysis of these macro-historical trends in human population usually focuses on this population growth and on the "demographic transition" underlying it.

During the first stage of the demographic transition, life — as Hobbes rightly suggested — was nasty, brutish, and short. There was a balance between birth rates and death rates, and both were very high (30-50 per thousand people per year). The human population grew less than 0.05% annually, with a doubling time of over 1,000 years. This state of affairs was true of all human populations everywhere until the late 18th century.

Then, during the second stage, the death rate began to decline — first in northwestern Europe, but then spreading over the next 100 years to the south and east. The decline in the death rate was due initially to improvements in food supply and in public health, both of which reduced mortality, particularly in childhood. As a consequence, there was a population explosion.

During the third stage, birth rates dropped for the first time in human history. The prior decline in childhood mortality probably prompted parents to realize they did not need as many children; and increasing urbanization, increasing female literacy, and (eventually) contraceptive technology also played a part.

Finally, during the fourth stage — in which the developed world presently finds itself — there is renewed stability. Birth and death rates are again in balance, but now both are relatively low. Causes of mortality have shifted from the pre-Modern pattern dominated by infectious diseases, perinatal diseases, and nutritional diseases, to one dominated by chronic diseases, mental illnesses, and behavioral conditions.

This broad story, however, conceals as much as it reveals. There are other demographic developments worldwide beyond the increasing overall size of the population, developments that are still unfolding and that matter much more. Changes in four aspects of population structure are key: (1) sex ratio, (2) age structure, (3) kinship systems, and (4) income distribution.

Sex ratios are becoming increasingly unbalanced in many parts of the world, especially in China and India (which account for 37% of the global population). The normal sex ratio at birth is roughly 106 males for every 100 females, but it may presently be as high as 120 for young people in China, or as high as 111 in India. This shift has been much discussed, and may arise from preferential abortion, cessation of reproduction if the first child happens to be a boy (but not if the child is a girl), or neglect of baby girls relative to boys. Gender imbalance may also have other determinants, such as large-scale migration of one or the other sex in search of work. This shift has numerous implications. For example, given the historical role of females as caregivers to elderly parents, a shortage of woman to fill this role will induce large-scale social adjustments. Moreover, an excess of low-status men unable to find wives results in an easy (and large) pool of recruits for extremism and violence.

This shift in gender ratios may have other, less heralded implications, however. Some of our own work has suggested that this shift may actually shorten men’s lives, reversing some of the historic progress we have made. Across a range of species, skewed sex ratios result in intensified competition for sexual partners and this induces stress for the supernumerary sex. In humans, it seems, a 5% excess of males at the time of sexual maturity shortens the survival of men by about three months in late life, which is a very substantial loss.

On the other hand, the population worldwide is getting older, especially in the developed world. Globally, the UN estimates that the proportion of people aged 60 and over will double between 2000 and 2050, from 10% to 21%, and the proportion of children will drop from 30% to 21%. This change also has numerous implications, including on the "dependency ratio," meaning that fewer young people are available to provide for the medical and economic needs of the elderly. Much less heralded, however, is the fact that war is a young person’s activity, and it is entirely likely that, as populations age, they may become less aggressive.

The changing nature of kinship networks, such as the growth in blended families — whether due to changing divorce patterns in the developed world or AIDS killing off parents in Africa — has implications for the network of obligations and entitlements within families. Changing kinship systems in modern American society (with complex mixtures of remarried and cohabiting couples, half-siblings, step-siblings, and so on) are having profound implications for caregiving, retirement, and bequests. Who cares for Grandma? Who gets her money when she dies?

Finally, it is not just the balance between males and females, or young and old, that is changing, but also the balance between rich and poor. Income inequality is reaching historic heights throughout the world. The top 1% of the people in the world receives 57% of the income. Income inequality in the US is presently at its highest recorded levels, exceeding even the Roaring Twenties. And while economic development in China has proceeded with astonishing rapidity, income is not evenly distributed; the prospects for conflict in that country as a result seem very high in the coming decades.

Lacking any real predators, a key feature of the human environment is other humans. In our rush to focus on threats such as global warming and environmental degradation, we should not overlook this fact. It is well to look around at who, and not just what, surrounds us. Population structure will change everything. Our health, wealth, and peace depend on it.


NEIL GERSHENFELD
Physicist, MIT; Author, FAB

THE RE-IMPLEMENTATION OF LIFE IN ENGINEERED MATERIALS

Life is defined by organic chemistry. There's software for artificial life and artificial intelligence, but these are, well, artificial — they exist in silico rather than in vivo. Conversely, synthetic biology is re-coding genes, but it isn't very synthetic; it uses the same sets of proteins as the rest of molecular biology. If, however, bits could carry mass as well as information, the distinction between artificial and synthetic life would disappear. Virtual and physical replication would be equivalent.

There are in fact promising laboratory systems that can compute with bits represented by mesoscopic materials rather than electrons or photons. Among the many reasons to do this, the most compelling is fabrication: instead of a code controlling a machine to make a thing, the code can itself become a thing (or many things).

That sounds a lot like life. Indeed, current work is developing micron-scale engineered analogs to amino acids, proteins, and genes, a "millibiology" to complement the existing microbiology. By working with components that have macroscopic physics but microscopic sizes, the primitive elements can be selected for their electronic, magnetic, optical or mechanical properties as well as active chemical groups.

Biotechnology is booming (if not bubbling). But it is very clearly segregated from other kinds of technology, which contribute to the study of, but not the identity of, biology. If, however, life is understood as an algorithm rather than a set of amino acids, then the creation of such really-artificial or really-synthetic life can enlarge the available materials, length, and energy scales. In such a world, biotechnology, nanotechnology, information technology, and manufacturing technology merge into a kind of universal technology of embodied information. Beyond the profound practical implications, forward- rather than reverse-engineering life may be the best way to understand it.


ANTON ZEILINGER
University of Vienna and Scientific Director, Institute of Quantum Optics and Quantum Information, Austrian Academy of Sciences

THE BREAKDOWN OF ALL COMPUTERS

Some day all semiconductors will break down and therefore all computers as, besides historic instruments no computers exist today which are nor based on semiconductor technology. The breakdown will be caused by a giant electromagnetic pulse (EMP) created by a nucler explosion outside Earth's athmosphere. It will cover large areas on Earth up to the size of a continent. Where it will happen is unpredictable. But it will happen since it is exteremely unlikely that we will be able to get rid of all nuclear weapons and the probabilty for it to happen at any given time will never be zero.

The implications of such an event will be enormous. If it happens to one of our technology based societies literally everything will break down. You will realize that none your phones does work. There is no way to find out via the internet what happened. Your car will not start anymore as it is also controlled by computer chips, unless you are lucky to own an antique car. Your local supermarket is unable to get new supplies.There will be no trucks operating anymore, no trains, no elctricity, no water supplies Society will completely break down.

There will be small exceptions in those countries where military equipment has been hardened against EMPs making the army available for emrgency relief. In some countires even some emergency civilian infrastructure has been hardened against EMPs. But these are exceptions as most goverments simply ignore that danger.

 


YOCHAI BENKLER